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Biodentine™ material characteristics and clinical applications : a 3 year literature review update

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Abstract
Introduction: Biodentine (TM) has frequently been acknowledged in the literature as a promising material and serves as an important representative of tricalcium silicate based cements used in dentistry. Aim: To provide an update on the physical and biological properties of Biodentine (TM) and to compare these properties with those of other tricalcium silicate cements namely, different variants of mineral trioxide aggregate (MTA) such as ProRoot MTA, MTA Angelus, Micro Mega MTA (MM-MTA), Retro MTA, Ortho MTA, MTA Plus, GCMTA, MTA HP and calcium enriched mixture (CEM), Endosequence and Bioaggregate (TM). Study design: A comprehensive literature search for publications from November 20, 2013 to November 20, 2016 was performed by two independent reviewers on Medline (PubMed), Embase, Web of Science, CENTRAL (Cochrane), SIGLE, SciELO, Scopus, Lilacs and clinicaltrials.gov. Electronic and hand search was carried out to identify randomised control trials (RCTs), case control studies, case series, case reports, as well as in vitro and animal studies published in the English language. Conclusions: The enhanced physical and biologic properties of Biodentine (TM) could be attributed to the presence of finer particle size, use of zirconium oxide as radiopacifier, purity of tricalcium silicate, absence of dicalcium silicate, and the addition of calcium chloride and hydrosoluble polymer. Furthermore, as Biodentine (TM) overcomes the major drawbacks of MTA it has great potential to revolutionise the different treatment modalities in paediatric dentistry and endodontics especially after traumatic injuries. Nevertheless, high quality long-term clinical studies are required to facilitate definitive conclusions.
Keywords
Biodentine (TM), Tricalcium silicate, MINERAL TRIOXIDE AGGREGATE, SILICATE-BASED CEMENTS, END FILLING MATERIALS, GLASS-IONOMER CEMENT, SHEAR BOND STRENGTH, ENDODONTIC REPARATIVE MATERIALS, INVASIVE CERVICAL RESORPTION, ACTIVATED PROTEIN-KINASE, PULP CAPPING MATERIALS, CALCIUM-SILICATE

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Citation

Please use this url to cite or link to this publication:

Chicago
Rajasekharan, Sivaprakash, Luc Martens, Rita Cauwels, Robert P Anthonappa, and Ronald Verbeeck. 2018. “BiodentineTM Material Characteristics and Clinical Applications : a 3 Year Literature Review Update.” European Archives of Paediatric Dentistry 19 (12): 1–22.
APA
Rajasekharan, Sivaprakash, Martens, L., Cauwels, R., Anthonappa, R. P., & Verbeeck, R. (2018). BiodentineTM material characteristics and clinical applications : a 3 year literature review update. EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY, 19(12), 1–22.
Vancouver
1.
Rajasekharan S, Martens L, Cauwels R, Anthonappa RP, Verbeeck R. BiodentineTM material characteristics and clinical applications : a 3 year literature review update. EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY. 2018;19(12):1–22.
MLA
Rajasekharan, Sivaprakash, Luc Martens, Rita Cauwels, et al. “BiodentineTM Material Characteristics and Clinical Applications : a 3 Year Literature Review Update.” EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY 19.12 (2018): 1–22. Print.
@article{8545101,
  abstract     = {Introduction: Biodentine (TM) has frequently been acknowledged in the literature as a promising material and serves as an important representative of tricalcium silicate based cements used in dentistry. 
Aim: To provide an update on the physical and biological properties of Biodentine (TM) and to compare these properties with those of other tricalcium silicate cements namely, different variants of mineral trioxide aggregate (MTA) such as ProRoot MTA, MTA Angelus, Micro Mega MTA (MM-MTA), Retro MTA, Ortho MTA, MTA Plus, GCMTA, MTA HP and calcium enriched mixture (CEM), Endosequence and Bioaggregate (TM). 
Study design: A comprehensive literature search for publications from November 20, 2013 to November 20, 2016 was performed by two independent reviewers on Medline (PubMed), Embase, Web of Science, CENTRAL (Cochrane), SIGLE, SciELO, Scopus, Lilacs and clinicaltrials.gov. Electronic and hand search was carried out to identify randomised control trials (RCTs), case control studies, case series, case reports, as well as in vitro and animal studies published in the English language. 
Conclusions: The enhanced physical and biologic properties of Biodentine (TM) could be attributed to the presence of finer particle size, use of zirconium oxide as radiopacifier, purity of tricalcium silicate, absence of dicalcium silicate, and the addition of calcium chloride and hydrosoluble polymer. Furthermore, as Biodentine (TM) overcomes the major drawbacks of MTA it has great potential to revolutionise the different treatment modalities in paediatric dentistry and endodontics especially after traumatic injuries. Nevertheless, high quality long-term clinical studies are required to facilitate definitive conclusions.},
  author       = {Rajasekharan, Sivaprakash and Martens, Luc and Cauwels, Rita and Anthonappa, Robert P and Verbeeck, Ronald},
  issn         = {1818-6300},
  journal      = {EUROPEAN ARCHIVES OF PAEDIATRIC DENTISTRY},
  keyword      = {Biodentine (TM),Tricalcium silicate,MINERAL TRIOXIDE AGGREGATE,SILICATE-BASED CEMENTS,END FILLING MATERIALS,GLASS-IONOMER CEMENT,SHEAR BOND STRENGTH,ENDODONTIC REPARATIVE MATERIALS,INVASIVE CERVICAL RESORPTION,ACTIVATED PROTEIN-KINASE,PULP CAPPING MATERIALS,CALCIUM-SILICATE},
  language     = {eng},
  number       = {12},
  pages        = {1--22},
  title        = {Biodentine{\texttrademark} material characteristics and clinical applications : a 3 year literature review update},
  url          = {http://dx.doi.org/10.1007/s40368-018-0328-x},
  volume       = {19},
  year         = {2018},
}

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