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Differences in white matter structure and cortical thickness between patients with traumatic and idiopathic chronic neck pain : associations with cognition and pain modulation?

(2018) HUMAN BRAIN MAPPING. 39(4). p.1721-1742
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Abstract
Brain alterations are hypothesized to be present in patients with chronic whiplash-associated disorders (CWAD). The aim of this case-control study was to examine alterations in cortical thickness and white matter (WM) structure, and the presence of brain microhemorrhages in a patient group encountering chronic neck pain of traumatic origin (i.e., CWAD) when compared with a patient group characterized by nontraumatic chronic neck pain [i.e., chronic idiopathic neck pain (CINP)], and healthy controls. Furthermore, we aimed to investigate associations between brain structure on one hand and cognitive performance and central sensitization (CS) on the other hand. T1-weighted, diffusion-weighted and T2*-weighted magnetic resonance images of the brain were acquired in 105 women (31 controls, 37 CINP, 37 CWAD) to investigate regional cortical thickness, WM structure, and microhemorrhages, respectively. Next, cognitive performance, and CS encompassing distant hyperalgesia and conditioned pain modulation (CPM) efficacy were examined. Cortical thinning in the left precuneus was revealed in CWAD compared with CINP patients. Also, decreased fractional anisotropy, together with increased values of mean diffusivity and radial diffusivity could be observed in the left cingulum hippocampus and tapetum in CWAD compared with CINP, and in the left tapetum in CWAD patients compared with controls. Moreover, the extent of WM structural deficits in the left tapetum coincided with decreased CPM efficacy in the CWAD group. This yields evidence for associations between decreased endogenous pain inhibition, and the degree of regional WM deficits in CWAD. Our results emphasize the role of structural brain alterations in women with CWAD compared with CINP.
Keywords
chronic idiopathic neck pain, chronic whiplash-associated disorders, central sensitization, cognitive performance, cortical thickness, magnetic resonance imaging, white matter, WHIPLASH-ASSOCIATED DISORDERS, HUMAN CEREBRAL-CORTEX, DIFFUSION-TENSOR MRI, CHRONIC MUSCULOSKELETAL PAIN, IRRITABLE-BOWEL-SYNDROME, DEFAULT MODE NETWORK, LOW-BACK-PAIN, BRAIN-INJURY, FUNCTIONAL CONNECTIVITY, CENTRAL SENSITIZATION

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Chicago
Coppieters, Iris, Robby De Pauw, Karen Caeyenberghs, Dorine Lenoir, Karel Deblaere, Eva Genbrugge, Mira Meeus, and Barbara Cagnie. 2018. “Differences in White Matter Structure and Cortical Thickness Between Patients with Traumatic and Idiopathic Chronic Neck Pain : Associations with Cognition and Pain Modulation?” Human Brain Mapping 39 (4): 1721–1742.
APA
Coppieters, I., De Pauw, R., Caeyenberghs, K., Lenoir, D., Deblaere, K., Genbrugge, E., Meeus, M., et al. (2018). Differences in white matter structure and cortical thickness between patients with traumatic and idiopathic chronic neck pain : associations with cognition and pain modulation? HUMAN BRAIN MAPPING, 39(4), 1721–1742.
Vancouver
1.
Coppieters I, De Pauw R, Caeyenberghs K, Lenoir D, Deblaere K, Genbrugge E, et al. Differences in white matter structure and cortical thickness between patients with traumatic and idiopathic chronic neck pain : associations with cognition and pain modulation? HUMAN BRAIN MAPPING. 2018;39(4):1721–42.
MLA
Coppieters, Iris, Robby De Pauw, Karen Caeyenberghs, et al. “Differences in White Matter Structure and Cortical Thickness Between Patients with Traumatic and Idiopathic Chronic Neck Pain : Associations with Cognition and Pain Modulation?” HUMAN BRAIN MAPPING 39.4 (2018): 1721–1742. Print.
@article{8544386,
  abstract     = {Brain alterations are hypothesized to be present in patients with chronic whiplash-associated disorders (CWAD). The aim of this case-control study was to examine alterations in cortical thickness and white matter (WM) structure, and the presence of brain microhemorrhages in a patient group encountering chronic neck pain of traumatic origin (i.e., CWAD) when compared with a patient group characterized by nontraumatic chronic neck pain [i.e., chronic idiopathic neck pain (CINP)], and healthy controls. Furthermore, we aimed to investigate associations between brain structure on one hand and cognitive performance and central sensitization (CS) on the other hand. T1-weighted, diffusion-weighted and T2*-weighted magnetic resonance images of the brain were acquired in 105 women (31 controls, 37 CINP, 37 CWAD) to investigate regional cortical thickness, WM structure, and microhemorrhages, respectively. Next, cognitive performance, and CS encompassing distant hyperalgesia and conditioned pain modulation (CPM) efficacy were examined. Cortical thinning in the left precuneus was revealed in CWAD compared with CINP patients. Also, decreased fractional anisotropy, together with increased values of mean diffusivity and radial diffusivity could be observed in the left cingulum hippocampus and tapetum in CWAD compared with CINP, and in the left tapetum in CWAD patients compared with controls. Moreover, the extent of WM structural deficits in the left tapetum coincided with decreased CPM efficacy in the CWAD group. This yields evidence for associations between decreased endogenous pain inhibition, and the degree of regional WM deficits in CWAD. Our results emphasize the role of structural brain alterations in women with CWAD compared with CINP.},
  author       = {Coppieters, Iris and De Pauw, Robby and Caeyenberghs, Karen and Lenoir, Dorine and Deblaere, Karel and Genbrugge, Eva and Meeus, Mira and Cagnie, Barbara},
  issn         = {1065-9471},
  journal      = {HUMAN BRAIN MAPPING},
  keyword      = {chronic idiopathic neck pain,chronic whiplash-associated disorders,central sensitization,cognitive performance,cortical thickness,magnetic resonance imaging,white matter,WHIPLASH-ASSOCIATED DISORDERS,HUMAN CEREBRAL-CORTEX,DIFFUSION-TENSOR MRI,CHRONIC MUSCULOSKELETAL PAIN,IRRITABLE-BOWEL-SYNDROME,DEFAULT MODE NETWORK,LOW-BACK-PAIN,BRAIN-INJURY,FUNCTIONAL CONNECTIVITY,CENTRAL SENSITIZATION},
  language     = {eng},
  number       = {4},
  pages        = {1721--1742},
  title        = {Differences~in~white matter structure~and~cortical thickness~between~patients with traumatic and~idiopathic chronic neck pain : associations with cognition and pain modulation?},
  url          = {http://dx.doi.org/10.1002/hbm.23947},
  volume       = {39},
  year         = {2018},
}

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