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Cardiac autonomic function and reactivity tests in physically active subjects with moderately severe COPD

Jibril Mohammed (UGent) , Eric Derom (UGent) , Tine De Backer (UGent) , Inge De Wandele (UGent) and Patrick Calders (UGent)
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Organization
Abstract
Patients with chronic obstructive pulmonary disease (COPD) show impairments in the autonomic nervous systems (ANS) function, which is responsible for cardiac autonomic regulation. This study assessed the autonomic function and cardio-vagal reactivity in conveniently sampled subjects with COPD participating in a pulmonary rehabilitation (PR) program. Twenty-six subjects with COPD and 22 age and gender matched control subjects were evaluated. R-R intervals were collected at rest in supine position. Thereafter, resting autonomic function parameters comprising linear and nonlinear analyses of heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated. Autonomic reactivity tests comprising deep breathing (DB), Valsalva maneuver (VM), and head up tilt (HUT) were also performed. The results of this study indicated that resting autonomic function variables were generally reduced in COPD compared to controls. However, this difference was only statistically significant for a few HRV parameters: mean RR intervals, low frequency (LF), standard deviation of dispersion of points perpendicular to the line-of-identity (SD1), and approximate entropy (ApEn) (p < 0.05). The results also indicated that all cardio-vagal indices following the autonomic reactivity tests were comparable between COPD and controls (p > 0.05). It was concluded that subtle autonomic impairments exists in physically active COPD patients, and these autonomic function deficits were mainly recognized by resting HRV indices and not autonomic reactivity tests.
Keywords
autonomic reactivity, chronic obstructive, pulmonary disease, autonomic function, physically active, COPD, OBSTRUCTIVE PULMONARY-DISEASE, HEART-RATE-VARIABILITY, VALSALVA MANEUVER, BAROREFLEX SENSITIVITY, 4-WEEK REHABILITATION, EXERCISE CAPACITY, PRESSURE, INTERVAL, MODULATION, MANAGEMENT

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Chicago
Mohammed, Jibril, Eric Derom, Tine De Backer, Inge De Wandele, and Patrick Calders. 2018. “Cardiac Autonomic Function and Reactivity Tests in Physically Active Subjects with Moderately Severe COPD.” Copd-journal of Chronic Obstructive Pulmonary Disease 15 (1): 51–59.
APA
Mohammed, J., Derom, E., De Backer, T., De Wandele, I., & Calders, P. (2018). Cardiac autonomic function and reactivity tests in physically active subjects with moderately severe COPD. COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 15(1), 51–59.
Vancouver
1.
Mohammed J, Derom E, De Backer T, De Wandele I, Calders P. Cardiac autonomic function and reactivity tests in physically active subjects with moderately severe COPD. COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2018;15(1):51–9.
MLA
Mohammed, Jibril, Eric Derom, Tine De Backer, et al. “Cardiac Autonomic Function and Reactivity Tests in Physically Active Subjects with Moderately Severe COPD.” COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 15.1 (2018): 51–59. Print.
@article{8544235,
  abstract     = {Patients with chronic obstructive pulmonary disease (COPD) show impairments in the autonomic nervous systems (ANS) function, which is responsible for cardiac autonomic regulation. This study assessed the autonomic function and cardio-vagal reactivity in conveniently sampled subjects with COPD participating in a pulmonary rehabilitation (PR) program. Twenty-six subjects with COPD and 22 age and gender matched control subjects were evaluated. R-R intervals were collected at rest in supine position. Thereafter, resting autonomic function parameters comprising linear and nonlinear analyses of heart rate variability (HRV) and baroreceptor sensitivity (BRS) were calculated. Autonomic reactivity tests comprising deep breathing (DB), Valsalva maneuver (VM), and head up tilt (HUT) were also performed. The results of this study indicated that resting autonomic function variables were generally reduced in COPD compared to controls. However, this difference was only statistically significant for a few HRV parameters: mean RR intervals, low frequency (LF), standard deviation of dispersion of points perpendicular to the line-of-identity (SD1), and approximate entropy (ApEn) (p {\textlangle} 0.05). The results also indicated that all cardio-vagal indices following the autonomic reactivity tests were comparable between COPD and controls (p {\textrangle} 0.05). It was concluded that subtle autonomic impairments exists in physically active COPD patients, and these autonomic function deficits were mainly recognized by resting HRV indices and not autonomic reactivity tests.},
  author       = {Mohammed, Jibril and Derom, Eric and De Backer, Tine and De Wandele, Inge and Calders, Patrick},
  issn         = {1541-2555},
  journal      = {COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE},
  keyword      = {autonomic reactivity,chronic obstructive,pulmonary disease,autonomic function,physically active,COPD,OBSTRUCTIVE PULMONARY-DISEASE,HEART-RATE-VARIABILITY,VALSALVA MANEUVER,BAROREFLEX SENSITIVITY,4-WEEK REHABILITATION,EXERCISE CAPACITY,PRESSURE,INTERVAL,MODULATION,MANAGEMENT},
  language     = {eng},
  number       = {1},
  pages        = {51--59},
  title        = {Cardiac autonomic function and reactivity tests in physically active subjects with moderately severe COPD},
  url          = {http://dx.doi.org/10.1080/15412555.2017.1412414},
  volume       = {15},
  year         = {2018},
}

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