Advanced search
1 file | 2.10 MB

Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules : synthesis, loading and in vivo applications

Author
Organization
Abstract
Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO3) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO3 scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug. Release of TA from the scaffolds was realized by recrystallization of the porous vaterite phase of calcium carbonate into the crystalline calcite. Cell colonization and tissue vascularization as well as transplantability of developed PCL/CaCO3 + TA scaffolds were observed. Detailed study of scaffold transformations during 21-day implantation period was followed by scanning electron microscopy and X-ray diffraction studies before and after in vivo implantation. The presented results demonstrate that PCL/CaCO3 scaffolds are attractive candidates for implants in bone regeneration and tissue engineering with a possibility of loading biologically active molecules and controlled release.
Keywords
Calcium carbonate, Scaffold drug delivery, Tissue regeneration, In vivo biocompatibility, Tannic acid, Rat, BIOMEDICAL APPLICATIONS, DRUG-DELIVERY, TANNIC-ACID, POLYCAPROLACTONE SCAFFOLDS, ENDOTHELIAL-CELLS, BONE REGENERATION, ELECTROSPUN, PARTICLES, MUSCLE, VITRO

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 2.10 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Saveleva, Mariia, AN Ivanov, MO Kurtukova, VS Atkin, AG Ivanova, GP Lyubun, AV Martyukova, et al. 2018. “Hybrid PCL/CaCO3 Scaffolds with Capabilities of Carrying Biologically Active Molecules : Synthesis, Loading and in Vivo Applications.” Materials Science & Engineering C-materials for Biological Applications 85: 57–67.
APA
Saveleva, M., Ivanov, A., Kurtukova, M., Atkin, V., Ivanova, A., Lyubun, G., Martyukova, A., et al. (2018). Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules : synthesis, loading and in vivo applications. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 85, 57–67.
Vancouver
1.
Saveleva M, Ivanov A, Kurtukova M, Atkin V, Ivanova A, Lyubun G, et al. Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules : synthesis, loading and in vivo applications. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. Elsevier BV; 2018;85:57–67.
MLA
Saveleva, Mariia, AN Ivanov, MO Kurtukova, et al. “Hybrid PCL/CaCO3 Scaffolds with Capabilities of Carrying Biologically Active Molecules : Synthesis, Loading and in Vivo Applications.” MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 85 (2018): 57–67. Print.
@article{8544013,
  abstract     = {Designing advanced biomaterials for tissue regeneration with drug delivery and release functionalities remains a challenge in regenerative medicine. In this research, we have developed novel composite scaffolds based on polymeric polycaprolactone fibers coated with porous calcium carbonate structures (PCL/CaCO3) for tissue engineering and have shown their drug delivery and release in rats. In vivo biocompatibility tests of PCL/CaCO3 scaffolds were complemented with in vivo drug release study, where tannic acid (TA) was used as a model drug. Release of TA from the scaffolds was realized by recrystallization of the porous vaterite phase of calcium carbonate into the crystalline calcite. Cell colonization and tissue vascularization as well as transplantability of developed PCL/CaCO3 + TA scaffolds were observed. Detailed study of scaffold transformations during 21-day implantation period was followed by scanning electron microscopy and X-ray diffraction studies before and after in vivo implantation. The presented results demonstrate that PCL/CaCO3 scaffolds are attractive candidates for implants in bone regeneration and tissue engineering with a possibility of loading biologically active molecules and controlled release.},
  author       = {Saveleva, Mariia and Ivanov, AN and Kurtukova, MO and Atkin, VS and Ivanova, AG and Lyubun, GP and Martyukova, AV and Cherevko, EI and Sargsyan, AK and Fedonnikov, AS and Norkin, IA and Skirtach, Andre and Gorin, DA and Parakhonskiy, Bogdan},
  issn         = {0928-4931},
  journal      = {MATERIALS SCIENCE \& ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS},
  language     = {eng},
  pages        = {57--67},
  publisher    = {Elsevier BV},
  title        = {Hybrid PCL/CaCO3 scaffolds with capabilities of carrying biologically active molecules : synthesis, loading and in vivo applications},
  url          = {http://dx.doi.org/10.1016/j.msec.2017.12.019},
  volume       = {85},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: