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Wounding induces dedifferentiation of epidermal Gata6⁺ cells and acquisition of stem cell properties

(2017) NATURE CELL BIOLOGY. 19(6). p.603-613
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Abstract
The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 downstream transcription factor network that specifies a lineage switch between sebocytes and SD cells. During wound healing differentiated Gata6(+) cells migrate from the SD into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue. Our data not only demonstrate that the structural and functional complexity of the junctional zone is regulated by Gata6, but also reveal that dedifferentiation is a previously unrecognized property of post-mitotic, terminally differentiated cells that have lost contact with the basement membrane. This resolves the long-standing debate about the contribution of terminally differentiated cells to epidermal wound repair.
Keywords
CRE-MEDIATED RECOMBINATION, HAIR FOLLICLE, TRANSCRIPTION FACTORS, SEBACEOUS GLAND, INTERFOLLICULAR EPIDERMIS, EPITHELIAL-CELLS, TERMINAL, DIFFERENTIATION, INTERACTION NETWORKS, PROGENITOR CELLS, SKIN

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Citation

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Chicago
Donati, Giacomo, Emanuel Rognoni, Toru Hiratsuka, Kifayathullah Liakath-Ali, Esther Hoste, Gozde Kar, Melis Kayikci, et al. 2017. “Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties.” Nature Cell Biology 19 (6): 603–613.
APA
Donati, G., Rognoni, E., Hiratsuka, T., Liakath-Ali, K., Hoste, E., Kar, G., Kayikci, M., et al. (2017). Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties. NATURE CELL BIOLOGY, 19(6), 603–613.
Vancouver
1.
Donati G, Rognoni E, Hiratsuka T, Liakath-Ali K, Hoste E, Kar G, et al. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties. NATURE CELL BIOLOGY. 2017;19(6):603–13.
MLA
Donati, Giacomo, Emanuel Rognoni, Toru Hiratsuka, et al. “Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties.” NATURE CELL BIOLOGY 19.6 (2017): 603–613. Print.
@article{8543774,
  abstract     = {The epidermis is maintained by multiple stem cell populations whose progeny differentiate along diverse, and spatially distinct, lineages. Here we show that the transcription factor Gata6 controls the identity of the previously uncharacterized sebaceous duct (SD) lineage and identify the Gata6 downstream transcription factor network that specifies a lineage switch between sebocytes and SD cells. During wound healing differentiated Gata6(+) cells migrate from the SD into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue. Our data not only demonstrate that the structural and functional complexity of the junctional zone is regulated by Gata6, but also reveal that dedifferentiation is a previously unrecognized property of post-mitotic, terminally differentiated cells that have lost contact with the basement membrane. This resolves the long-standing debate about the contribution of terminally differentiated cells to epidermal wound repair.},
  author       = {Donati, Giacomo and Rognoni, Emanuel and Hiratsuka, Toru and Liakath-Ali, Kifayathullah and Hoste, Esther and Kar, Gozde and Kayikci, Melis and Russell, Roslin and Kretzschmar, Kai and Mulder, Klaas W and Teichmann, Sarah A and Watt, Fiona M},
  issn         = {1465-7392},
  journal      = {NATURE CELL BIOLOGY},
  language     = {eng},
  number       = {6},
  pages        = {603--613},
  title        = {Wounding induces dedifferentiation of epidermal Gata6\unmatched{207a} cells and acquisition of stem cell properties},
  url          = {http://dx.doi.org/10.1038/ncb3532},
  volume       = {19},
  year         = {2017},
}

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