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Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

Elisabeth Peeters, Ana Tavares da Silva UGent, Maunu Toiviainen, Jeroen Van Renterghem UGent, Jurgen Vercruysse UGent, Mikko Juuti, Joao Almeida Lopes, Thomas De Beer UGent, Chris Vervaet UGent and Jean Paul Remon UGent (2016) ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 11(4). p.547-558
abstract
This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Continuous production, PAT, Granulation, Tableting, NIR, Raman, NEAR-INFRARED SPECTROSCOPY, TWIN-SCREW GRANULATION, DIFFUSE-REFLECTANCE SPECTROSCOPY, WET GRANULATION, NONDESTRUCTIVE METHOD, DRUG CONTENT, HARDNESS, GRANULES, SCATTERING, REDUCTION
journal title
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Asian J. Pharm. Sci.
volume
11
issue
4
pages
547 - 558
Web of Science type
Article
Web of Science id
000384282900011
ISSN
1818-0876
DOI
10.1016/j.ajps.2016.04.004
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8543524
handle
http://hdl.handle.net/1854/LU-8543524
date created
2018-01-03 19:38:36
date last changed
2018-05-22 08:55:39
@article{8543524,
  abstract     = {This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.},
  author       = {Peeters, Elisabeth and Tavares da Silva, Ana and Toiviainen, Maunu and Van Renterghem, Jeroen and Vercruysse, Jurgen and Juuti, Mikko and Lopes, Joao Almeida and De Beer, Thomas and Vervaet, Chris and Remon, Jean Paul},
  issn         = {1818-0876},
  journal      = {ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES},
  keyword      = {Continuous production,PAT,Granulation,Tableting,NIR,Raman,NEAR-INFRARED SPECTROSCOPY,TWIN-SCREW GRANULATION,DIFFUSE-REFLECTANCE SPECTROSCOPY,WET GRANULATION,NONDESTRUCTIVE METHOD,DRUG CONTENT,HARDNESS,GRANULES,SCATTERING,REDUCTION},
  language     = {eng},
  number       = {4},
  pages        = {547--558},
  title        = {Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy},
  url          = {http://dx.doi.org/10.1016/j.ajps.2016.04.004},
  volume       = {11},
  year         = {2016},
}

Chicago
Peeters, Elisabeth, Ana Tavares da Silva, Maunu Toiviainen, Jeroen Van Renterghem, Jurgen Vercruysse, Mikko Juuti, Joao Almeida Lopes, Thomas De Beer, Chris Vervaet, and Jean Paul Remon. 2016. “Assessment and Prediction of Tablet Properties Using Transmission and Backscattering Raman Spectroscopy and Transmission NIR Spectroscopy.” Asian Journal of Pharmaceutical Sciences 11 (4): 547–558.
APA
Peeters, Elisabeth, Tavares da Silva, A., Toiviainen, M., Van Renterghem, J., Vercruysse, J., Juuti, M., Lopes, J. A., et al. (2016). Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 11(4), 547–558.
Vancouver
1.
Peeters E, Tavares da Silva A, Toiviainen M, Van Renterghem J, Vercruysse J, Juuti M, et al. Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2016;11(4):547–58.
MLA
Peeters, Elisabeth, Ana Tavares da Silva, Maunu Toiviainen, et al. “Assessment and Prediction of Tablet Properties Using Transmission and Backscattering Raman Spectroscopy and Transmission NIR Spectroscopy.” ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 11.4 (2016): 547–558. Print.