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Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

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Abstract
This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.
Keywords
Continuous production, PAT, Granulation, Tableting, NIR, Raman, NEAR-INFRARED SPECTROSCOPY, TWIN-SCREW GRANULATION, DIFFUSE-REFLECTANCE SPECTROSCOPY, WET GRANULATION, NONDESTRUCTIVE METHOD, DRUG CONTENT, HARDNESS, GRANULES, SCATTERING, REDUCTION

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Citation

Please use this url to cite or link to this publication:

Chicago
Peeters, Elisabeth, Ana Tavares da Silva, Maunu Toiviainen, Jeroen Van Renterghem, Jurgen Vercruysse, Mikko Juuti, Joao Almeida Lopes, Thomas De Beer, Chris Vervaet, and Jean Paul Remon. 2016. “Assessment and Prediction of Tablet Properties Using Transmission and Backscattering Raman Spectroscopy and Transmission NIR Spectroscopy.” Asian Journal of Pharmaceutical Sciences 11 (4): 547–558.
APA
Peeters, Elisabeth, Tavares da Silva, A., Toiviainen, M., Van Renterghem, J., Vercruysse, J., Juuti, M., Lopes, J. A., et al. (2016). Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 11(4), 547–558.
Vancouver
1.
Peeters E, Tavares da Silva A, Toiviainen M, Van Renterghem J, Vercruysse J, Juuti M, et al. Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2016;11(4):547–58.
MLA
Peeters, Elisabeth, Ana Tavares da Silva, Maunu Toiviainen, et al. “Assessment and Prediction of Tablet Properties Using Transmission and Backscattering Raman Spectroscopy and Transmission NIR Spectroscopy.” ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 11.4 (2016): 547–558. Print.
@article{8543524,
  abstract     = {This study investigated whether Raman and Near Infrared (NIR) spectroscopy could predict tablet properties. Granules were produced on a continuous line by varying granulation parameters. Tableting process parameters were adjusted to obtain uniform tablet weight and thickness. Spectra were collected offline and tablet properties determined with traditional analyzing methods. Partial Least Squares (PLS) regression was used to correlate spectral information to tablet properties, but predictive models couldn't be established. Principal component analysis (PCA) was effectively used to distinguish theophylline concentrations and hydration levels and multiple linear regression (MLR) analysis allowed insight on how granulation parameters affect granule and tablet properties.},
  author       = {Peeters, Elisabeth and Tavares da Silva, Ana and Toiviainen, Maunu and Van Renterghem, Jeroen and Vercruysse, Jurgen and Juuti, Mikko and Lopes, Joao Almeida and De Beer, Thomas and Vervaet, Chris and Remon, Jean Paul},
  issn         = {1818-0876},
  journal      = {ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES},
  keyword      = {Continuous production,PAT,Granulation,Tableting,NIR,Raman,NEAR-INFRARED SPECTROSCOPY,TWIN-SCREW GRANULATION,DIFFUSE-REFLECTANCE SPECTROSCOPY,WET GRANULATION,NONDESTRUCTIVE METHOD,DRUG CONTENT,HARDNESS,GRANULES,SCATTERING,REDUCTION},
  language     = {eng},
  number       = {4},
  pages        = {547--558},
  title        = {Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy},
  url          = {http://dx.doi.org/10.1016/j.ajps.2016.04.004},
  volume       = {11},
  year         = {2016},
}

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