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Reciprocally retained genes in the angiosperm lineage show the hallmarks of dosage balance sensitivity

Setareh Tasdighian UGent, Michiel Van Bel UGent, Zhen Li UGent, Yves Van de Peer UGent, Lorenzo Carretero-Paulet UGent and Steven Maere UGent (2017) PLANT CELL. 29(11). p.2766-2785
abstract
In several organisms, particular functional categories of genes, such as regulatory and complex-forming genes, are preferentially retained after whole-genome multiplications but rarely duplicate through small-scale duplication, a pattern referred to as reciprocal retention. This peculiar duplication behavior is hypothesized to stem from constraints on the dosage balance between the genes concerned and their interaction context. However, the evidence for a relationship between reciprocal retention and dosage balance sensitivity remains fragmentary. Here, we identified which gene families are most strongly reciprocally retained in the angiosperm lineage and studied their functional and evolutionary characteristics. Reciprocally retained gene families exhibit stronger sequence divergence constraints and lower rates of functional and expression divergence than other gene families, suggesting that dosage balance sensitivity is a general characteristic of reciprocally retained genes. Gene families functioning in regulatory and signaling processes are much more strongly represented at the top of the reciprocal retention ranking than those functioning in multiprotein complexes, suggesting that regulatory imbalances may lead to stronger fitness effects than classical stoichiometric protein complex imbalances. Finally, reciprocally retained duplicates are often subject to dosage balance constraints for prolonged evolutionary times, which may have repercussions for the ease with which genome multiplications can engender evolutionary innovation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
WHOLE-GENOME DUPLICATIONS, ZINC-FINGER PROTEINS, ARABIDOPSIS-THALIANA, PHLOEM DIFFERENTIATION, QUANTITATIVE TRAITS, SEMANTIC SIMILARITY, FLOWERING PLANTS, B2-TYPE CYCLIN, R PACKAGE, GO TERMS
journal title
PLANT CELL
Plant Cell
volume
29
issue
11
pages
2766 - 2785
Web of Science type
Article
Web of Science id
000417643700011
ISSN
1040-4651
1532-298X
DOI
10.1105/tpc.17.00313
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8543371
handle
http://hdl.handle.net/1854/LU-8543371
date created
2018-01-02 10:36:11
date last changed
2018-01-17 13:37:59
@article{8543371,
  abstract     = {In several organisms, particular functional categories of genes, such as regulatory and complex-forming genes, are preferentially retained after whole-genome multiplications but rarely duplicate through small-scale duplication, a pattern referred to as reciprocal retention. This peculiar duplication behavior is hypothesized to stem from constraints on the dosage balance between the genes concerned and their interaction context. However, the evidence for a relationship between reciprocal retention and dosage balance sensitivity remains fragmentary. Here, we identified which gene families are most strongly reciprocally retained in the angiosperm lineage and studied their functional and evolutionary characteristics. Reciprocally retained gene families exhibit stronger sequence divergence constraints and lower rates of functional and expression divergence than other gene families, suggesting that dosage balance sensitivity is a general characteristic of reciprocally retained genes. Gene families functioning in regulatory and signaling processes are much more strongly represented at the top of the reciprocal retention ranking than those functioning in multiprotein complexes, suggesting that regulatory imbalances may lead to stronger fitness effects than classical stoichiometric protein complex imbalances. Finally, reciprocally retained duplicates are often subject to dosage balance constraints for prolonged evolutionary times, which may have repercussions for the ease with which genome multiplications can engender evolutionary innovation.},
  author       = {Tasdighian, Setareh and Van Bel, Michiel and Li, Zhen and Van de Peer, Yves and Carretero-Paulet, Lorenzo and Maere, Steven},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {WHOLE-GENOME DUPLICATIONS,ZINC-FINGER PROTEINS,ARABIDOPSIS-THALIANA,PHLOEM DIFFERENTIATION,QUANTITATIVE TRAITS,SEMANTIC SIMILARITY,FLOWERING PLANTS,B2-TYPE CYCLIN,R PACKAGE,GO TERMS},
  language     = {eng},
  number       = {11},
  pages        = {2766--2785},
  title        = {Reciprocally retained genes in the angiosperm lineage show the hallmarks of dosage balance sensitivity},
  url          = {http://dx.doi.org/10.1105/tpc.17.00313},
  volume       = {29},
  year         = {2017},
}

Chicago
Tasdighian, Setareh, Michiel Van Bel, Zhen Li, Yves Van de Peer, Lorenzo Carretero-Paulet, and Steven Maere. 2017. “Reciprocally Retained Genes in the Angiosperm Lineage Show the Hallmarks of Dosage Balance Sensitivity.” Plant Cell 29 (11): 2766–2785.
APA
Tasdighian, S., Van Bel, M., Li, Z., Van de Peer, Y., Carretero-Paulet, L., & Maere, S. (2017). Reciprocally retained genes in the angiosperm lineage show the hallmarks of dosage balance sensitivity. PLANT CELL, 29(11), 2766–2785.
Vancouver
1.
Tasdighian S, Van Bel M, Li Z, Van de Peer Y, Carretero-Paulet L, Maere S. Reciprocally retained genes in the angiosperm lineage show the hallmarks of dosage balance sensitivity. PLANT CELL. 2017;29(11):2766–85.
MLA
Tasdighian, Setareh, Michiel Van Bel, Zhen Li, et al. “Reciprocally Retained Genes in the Angiosperm Lineage Show the Hallmarks of Dosage Balance Sensitivity.” PLANT CELL 29.11 (2017): 2766–2785. Print.