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Applications of mid-infrared spectroscopy in the clinical laboratory setting

Sander De Bruyne (UGent) , Marijn Speeckaert (UGent) and Joris Delanghe (UGent)
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Abstract
Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Although considerable technological progress has been made to promote biomedical applications of this powerful analytical technique, most clinical laboratory analyses are based on spectroscopic measurements in the visible or ultraviolet (UV) spectrum and the potential role of FTIR spectroscopy still remains unexplored. In this review, we present some general principles of FTIR spectroscopy as a useful method to study molecules in specimens by MIR radiation together with a short overview of methods to interpret spectral data. We aim at illustrating the wide range of potential applications of the proposed technique in the clinical laboratory setting with a focus on its advantages and limitations and discussing the future directions. The reviewed applications of MIR spectroscopy include (1) quantification of clinical parameters in body fluids, (2) diagnosis and monitoring of cancer and other diseases by analysis of body fluids, cells, and tissues, (3) classification of clinically relevant microorganisms, and (4) analysis of kidney stones, nails, and faecal fat.
Keywords
Clinical applications, Fourier transform infrared spectroscopy, medical laboratory science, mid-infrared absorbance spectroscopy, vibrational spectroscopy, TRANSFORM-INFRARED-SPECTROSCOPY, ATR-FTIR SPECTROSCOPY, SECONDARY STRUCTURAL-CHANGES, FETAL LUNG MATURITY, FECAL FAT, RAPID IDENTIFICATION, ALZHEIMERS-DISEASE, PERIPHERAL-BLOOD, DIAGNOSTIC-TOOL, OVARIAN-CANCER

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Citation

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Chicago
De Bruyne, Sander, Marijn Speeckaert, and Joris Delanghe. 2018. “Applications of Mid-infrared Spectroscopy in the Clinical Laboratory Setting.” Critical Reviews in Clinical Laboratory Sciences 55 (1): 1–20.
APA
De Bruyne, Sander, Speeckaert, M., & Delanghe, J. (2018). Applications of mid-infrared spectroscopy in the clinical laboratory setting. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 55(1), 1–20.
Vancouver
1.
De Bruyne S, Speeckaert M, Delanghe J. Applications of mid-infrared spectroscopy in the clinical laboratory setting. CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES. 2018;55(1):1–20.
MLA
De Bruyne, Sander, Marijn Speeckaert, and Joris Delanghe. “Applications of Mid-infrared Spectroscopy in the Clinical Laboratory Setting.” CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES 55.1 (2018): 1–20. Print.
@article{8543000,
  abstract     = {Fourier transform mid-infrared (MIR-FTIR) spectroscopy is a nondestructive, label-free, highly sensitive and specific technique that provides complete information on the chemical composition of biological samples. The technique both can offer fundamental structural information and serve as a quantitative analysis tool. Therefore, it has many potential applications in different fields of clinical laboratory science. Although considerable technological progress has been made to promote biomedical applications of this powerful analytical technique, most clinical laboratory analyses are based on spectroscopic measurements in the visible or ultraviolet (UV) spectrum and the potential role of FTIR spectroscopy still remains unexplored. In this review, we present some general principles of FTIR spectroscopy as a useful method to study molecules in specimens by MIR radiation together with a short overview of methods to interpret spectral data. We aim at illustrating the wide range of potential applications of the proposed technique in the clinical laboratory setting with a focus on its advantages and limitations and discussing the future directions. The reviewed applications of MIR spectroscopy include (1) quantification of clinical parameters in body fluids, (2) diagnosis and monitoring of cancer and other diseases by analysis of body fluids, cells, and tissues, (3) classification of clinically relevant microorganisms, and (4) analysis of kidney stones, nails, and faecal fat.},
  author       = {De Bruyne, Sander and Speeckaert, Marijn and Delanghe, Joris},
  issn         = {1040-8363},
  journal      = {CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES},
  keyword      = {Clinical applications,Fourier transform infrared spectroscopy,medical laboratory science,mid-infrared absorbance spectroscopy,vibrational spectroscopy,TRANSFORM-INFRARED-SPECTROSCOPY,ATR-FTIR SPECTROSCOPY,SECONDARY STRUCTURAL-CHANGES,FETAL LUNG MATURITY,FECAL FAT,RAPID IDENTIFICATION,ALZHEIMERS-DISEASE,PERIPHERAL-BLOOD,DIAGNOSTIC-TOOL,OVARIAN-CANCER},
  language     = {eng},
  number       = {1},
  pages        = {1--20},
  title        = {Applications of mid-infrared spectroscopy in the clinical laboratory setting},
  url          = {http://dx.doi.org/10.1080/10408363.2017.1414142.},
  volume       = {55},
  year         = {2018},
}

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