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A young woman with recurrent kidney stones : questions on hypokalaemic tubular acidosis

Jill Vanmassenhove (UGent) and Norbert Lameire (UGent)
(2017) NEPHROLOGY @ POINT OF CARE. 3(1). p.E9-E16
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Abstract
This paper discusses the diagnostic and therapeutic approach to the problem of a young woman presenting with recurrent kidney stones. In the clinical work-up, a hypokalaemic normal anion gap metabolic acidosis was found. The diagnostic tests to solve this common clinical problem and some therapeutic recommendations are discussed. Question on hypokalaemic tubular acidosis: 1. What is the significance of the plasma anion gap (PAG)? 2. How does one appreciate the respiratory component of the acid base status? 3. How does one perform tests for tubular acidification disturbances? 4. What is the pathogenesis of distal tubular acidification disturbances? 5. What is the explanation of the hypokalaemia in distal tubular acidosis? 6. What is the pathogenesis of nephrolithiasis in distal tubular acidosis? 7. How does one treat a patient with distal tubular acidosis and recurrent nephrolithiasis?
Keywords
PRIMARY SJOGRENS-SYNDROME, BLOOD PCO2 GRADIENT, RENAL INVOLVEMENT, BASE-DISORDERS, H+-ATPASE, URINE, EXCRETION, TRANSPORT, THERAPY, DEFECT, Kidney stones, Metabolic hypokalaemic tubular acidosis, Recurrent, nephrolithiasis

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Citation

Please use this url to cite or link to this publication:

MLA
Vanmassenhove, Jill, and Norbert Lameire. “A Young Woman with Recurrent Kidney Stones : Questions on Hypokalaemic Tubular Acidosis.” NEPHROLOGY @ POINT OF CARE 3.1 (2017): E9–E16. Print.
APA
Vanmassenhove, J., & Lameire, N. (2017). A young woman with recurrent kidney stones : questions on hypokalaemic tubular acidosis. NEPHROLOGY @ POINT OF CARE, 3(1), E9–E16.
Chicago author-date
Vanmassenhove, Jill, and Norbert Lameire. 2017. “A Young Woman with Recurrent Kidney Stones : Questions on Hypokalaemic Tubular Acidosis.” Nephrology @ Point of Care 3 (1): E9–E16.
Chicago author-date (all authors)
Vanmassenhove, Jill, and Norbert Lameire. 2017. “A Young Woman with Recurrent Kidney Stones : Questions on Hypokalaemic Tubular Acidosis.” Nephrology @ Point of Care 3 (1): E9–E16.
Vancouver
1.
Vanmassenhove J, Lameire N. A young woman with recurrent kidney stones : questions on hypokalaemic tubular acidosis. NEPHROLOGY @ POINT OF CARE. 2017;3(1):E9–E16.
IEEE
[1]
J. Vanmassenhove and N. Lameire, “A young woman with recurrent kidney stones : questions on hypokalaemic tubular acidosis,” NEPHROLOGY @ POINT OF CARE, vol. 3, no. 1, pp. E9–E16, 2017.
@article{8542688,
  abstract     = {This paper discusses the diagnostic and therapeutic approach to the problem of a young woman presenting with recurrent kidney stones. In the clinical work-up, a hypokalaemic normal anion gap metabolic acidosis was found. The diagnostic tests to solve this common clinical problem and some therapeutic recommendations are discussed. 
Question on hypokalaemic tubular acidosis: 
1. What is the significance of the plasma anion gap (PAG)? 
2. How does one appreciate the respiratory component of the acid base status? 
3. How does one perform tests for tubular acidification disturbances? 
4. What is the pathogenesis of distal tubular acidification disturbances? 
5. What is the explanation of the hypokalaemia in distal tubular acidosis? 
6. What is the pathogenesis of nephrolithiasis in distal tubular acidosis? 
7. How does one treat a patient with distal tubular acidosis and recurrent nephrolithiasis?},
  author       = {Vanmassenhove, Jill and Lameire, Norbert},
  issn         = {2059-3007},
  journal      = {NEPHROLOGY @ POINT OF CARE},
  keywords     = {PRIMARY SJOGRENS-SYNDROME,BLOOD PCO2 GRADIENT,RENAL INVOLVEMENT,BASE-DISORDERS,H+-ATPASE,URINE,EXCRETION,TRANSPORT,THERAPY,DEFECT,Kidney stones,Metabolic hypokalaemic tubular acidosis,Recurrent,nephrolithiasis},
  language     = {eng},
  number       = {1},
  pages        = {E9--E16},
  title        = {A young woman with recurrent kidney stones : questions on hypokalaemic tubular acidosis},
  url          = {http://dx.doi.org/10.5301/napoc.5000209},
  volume       = {3},
  year         = {2017},
}

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