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Calciphylaxis in a cardiac patient without renal disease

(2009) ACTA CARDIOLOGICA. 64(1). p.91-93
Author
Organization
Abstract
Calciphylaxis is a rare complication that occurs in 1% of patients with end-stage renal disease (ESRD) each year. Extensive microvascular calcification and occlusion/thrombosis lead to violaceous skin lesions, which progress to nonhealing ulcers with secondary infection, often leading to sepsis and death. The lower extremities are predominantly involved (roughly 90% of patients). Although most calciphylaxis patients have abnormalities of the calcium-phosphate axis or elevated levels of parathyroid hormone, these abnormalities do not appear to be fundamental to the pathophysiology of the disorder. We report on a case of histologically proven calciphylaxis in a 54-year-old woman with normal renal function and normal calcium-parathyroid homeostasis. She had a history of alcoholic cardiomyopathy, and was treated with warfarin anticoagulation. She has been successfully treated with antibiotics, i.v. biophosphonates and intensive locale wound care. We recorded a complete wound healing in contrast to what is reported in other series.
Keywords
calciphylaxis, ESRD, warfarin, CALCIFICATION

Citation

Please use this url to cite or link to this publication:

MLA
Almafragi, Amar, Jo Van Dorpe, and Karl Dujardin. “Calciphylaxis in a Cardiac Patient Without Renal Disease.” ACTA CARDIOLOGICA 64.1 (2009): 91–93. Print.
APA
Almafragi, A., Van Dorpe, J., & Dujardin, K. (2009). Calciphylaxis in a cardiac patient without renal disease. ACTA CARDIOLOGICA, 64(1), 91–93.
Chicago author-date
Almafragi, Amar, Jo Van Dorpe, and Karl Dujardin. 2009. “Calciphylaxis in a Cardiac Patient Without Renal Disease.” Acta Cardiologica 64 (1): 91–93.
Chicago author-date (all authors)
Almafragi, Amar, Jo Van Dorpe, and Karl Dujardin. 2009. “Calciphylaxis in a Cardiac Patient Without Renal Disease.” Acta Cardiologica 64 (1): 91–93.
Vancouver
1.
Almafragi A, Van Dorpe J, Dujardin K. Calciphylaxis in a cardiac patient without renal disease. ACTA CARDIOLOGICA. 2009;64(1):91–3.
IEEE
[1]
A. Almafragi, J. Van Dorpe, and K. Dujardin, “Calciphylaxis in a cardiac patient without renal disease,” ACTA CARDIOLOGICA, vol. 64, no. 1, pp. 91–93, 2009.
@article{8542288,
  abstract     = {Calciphylaxis is a rare complication that occurs in 1% of patients with end-stage renal disease (ESRD) each year. Extensive microvascular calcification and occlusion/thrombosis lead to violaceous skin lesions, which progress to nonhealing ulcers with secondary infection, often leading to sepsis and death. The lower extremities are predominantly involved (roughly 90% of patients). Although most calciphylaxis patients have abnormalities of the calcium-phosphate axis or elevated levels of parathyroid hormone, these abnormalities do not appear to be fundamental to the pathophysiology of the disorder. 
We report on a case of histologically proven calciphylaxis in a 54-year-old woman with normal renal function and normal calcium-parathyroid homeostasis. She had a history of alcoholic cardiomyopathy, and was treated with warfarin anticoagulation. She has been successfully treated with antibiotics, i.v. biophosphonates and intensive locale wound care. We recorded a complete wound healing in contrast to what is reported in other series.},
  author       = {Almafragi, Amar and Van Dorpe, Jo and Dujardin, Karl},
  issn         = {0001-5385},
  journal      = {ACTA CARDIOLOGICA},
  keywords     = {calciphylaxis,ESRD,warfarin,CALCIFICATION},
  language     = {eng},
  number       = {1},
  pages        = {91--93},
  title        = {Calciphylaxis in a cardiac patient without renal disease},
  url          = {http://dx.doi.org/10.2143/AC.64.1.2034368},
  volume       = {64},
  year         = {2009},
}

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