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Population-level analysis of gut microbiome variation

(2016) SCIENCE. 352(6285). p.560-564
Author
Organization
Abstract
Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design.
Keywords
FAECALIBACTERIUM-PRAUSNITZII, INTESTINAL MICROBIOTA, ENTEROTYPES, ACQUISITION, METAGENOME, DIVERSITY, RICHNESS, HEALTH, IMPACT, RISK

Citation

Please use this url to cite or link to this publication:

MLA
Falony, Gwen, et al. “Population-Level Analysis of Gut Microbiome Variation.” SCIENCE, vol. 352, no. 6285, 2016, pp. 560–64, doi:10.1126/science.aad3503.
APA
Falony, G., Joossens, M., Vieira-Silva, S., Wang, J., Darzi, Y., Faust, K., … Raes, J. (2016). Population-level analysis of gut microbiome variation. SCIENCE, 352(6285), 560–564. https://doi.org/10.1126/science.aad3503
Chicago author-date
Falony, Gwen, Marie Joossens, Sara Vieira-Silva, Jun Wang, Youssef Darzi, Karoline Faust, Alexander Kurilshikov, et al. 2016. “Population-Level Analysis of Gut Microbiome Variation.” SCIENCE 352 (6285): 560–64. https://doi.org/10.1126/science.aad3503.
Chicago author-date (all authors)
Falony, Gwen, Marie Joossens, Sara Vieira-Silva, Jun Wang, Youssef Darzi, Karoline Faust, Alexander Kurilshikov, Marc Jan Bonder, Mireia Valles-Colomer, Doris Vandeputte, Raul Y Tito, Samuel Chaffron, Leen Rymenans, Chlo Verspecht, Lise De Sutter, Gipsi Lima-Mendez, Kevin D’hoe, Karl Jonckheere, Daniel Homola, Roberto Garcia, Ettje F Tigchelaar, Linda Eeckhaudt, Jingyuan Fu, Liesbet Henckaerts, Alexandra Zhernakova, Cisca Wijmenga, and Jeroen Raes. 2016. “Population-Level Analysis of Gut Microbiome Variation.” SCIENCE 352 (6285): 560–564. doi:10.1126/science.aad3503.
Vancouver
1.
Falony G, Joossens M, Vieira-Silva S, Wang J, Darzi Y, Faust K, et al. Population-level analysis of gut microbiome variation. SCIENCE. 2016;352(6285):560–4.
IEEE
[1]
G. Falony et al., “Population-level analysis of gut microbiome variation,” SCIENCE, vol. 352, no. 6285, pp. 560–564, 2016.
@article{8540907,
  abstract     = {{Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design.}},
  author       = {{Falony, Gwen and Joossens, Marie and Vieira-Silva, Sara and Wang, Jun and Darzi, Youssef and Faust, Karoline and Kurilshikov, Alexander and Bonder, Marc Jan and Valles-Colomer, Mireia and Vandeputte, Doris and Tito, Raul Y and Chaffron, Samuel and Rymenans, Leen and Verspecht, Chlo and De Sutter, Lise and Lima-Mendez, Gipsi and D'hoe, Kevin and Jonckheere, Karl and Homola, Daniel and Garcia, Roberto and Tigchelaar, Ettje F and Eeckhaudt, Linda and Fu, Jingyuan and Henckaerts, Liesbet and Zhernakova, Alexandra and Wijmenga, Cisca and Raes, Jeroen}},
  issn         = {{0036-8075}},
  journal      = {{SCIENCE}},
  keywords     = {{FAECALIBACTERIUM-PRAUSNITZII,INTESTINAL MICROBIOTA,ENTEROTYPES,ACQUISITION,METAGENOME,DIVERSITY,RICHNESS,HEALTH,IMPACT,RISK}},
  language     = {{eng}},
  number       = {{6285}},
  pages        = {{560--564}},
  title        = {{Population-level analysis of gut microbiome variation}},
  url          = {{http://dx.doi.org/10.1126/science.aad3503}},
  volume       = {{352}},
  year         = {{2016}},
}

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