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Meta-omics in inflammatory bowel disease research : applications, challenges, and guidelines

(2016) JOURNAL OF CROHNS & COLITIS. 10(6). p.735-746
Author
Organization
Abstract
Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines.
Keywords
HUMAN GUT MICROBIOME, CROHNS-DISEASE, METATRANSCRIPTOMIC DATA, METAGENOMIC ANALYSIS, FECAL MICROBIOTA, SEQUENCING DATA, MARKER GENES, DYSBIOSIS, DATABASE, GENOMES, Metagenomics, metatranscriptomics, metaproteomics, 16S, meta-omics, microbiota

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Chicago
Valles-Colomer, Mireia, Youssef Darzi, Sara Vieira-Silva, Gwen Falony, Jeroen Raes, and Marie Joossens. 2016. “Meta-omics in Inflammatory Bowel Disease Research : Applications, Challenges, and Guidelines.” Journal of Crohns & Colitis 10 (6): 735–746.
APA
Valles-Colomer, M., Darzi, Y., Vieira-Silva, S., Falony, G., Raes, J., & Joossens, M. (2016). Meta-omics in inflammatory bowel disease research : applications, challenges, and guidelines. JOURNAL OF CROHNS & COLITIS, 10(6), 735–746.
Vancouver
1.
Valles-Colomer M, Darzi Y, Vieira-Silva S, Falony G, Raes J, Joossens M. Meta-omics in inflammatory bowel disease research : applications, challenges, and guidelines. JOURNAL OF CROHNS & COLITIS. 2016;10(6):735–46.
MLA
Valles-Colomer, Mireia, Youssef Darzi, Sara Vieira-Silva, et al. “Meta-omics in Inflammatory Bowel Disease Research : Applications, Challenges, and Guidelines.” JOURNAL OF CROHNS & COLITIS 10.6 (2016): 735–746. Print.
@article{8540906,
  abstract     = {Meta-omics [metagenomics, metatranscriptomics, and metaproteomics] are rapidly expanding our knowledge of the gut microbiota in health and disease. These technologies are increasingly used in inflammatory bowel disease [IBD] research. Yet, meta-omics data analysis, interpretation, and among-study comparison remain challenging. In this review we discuss the role these techniques are playing in IBD research, highlighting their strengths and limitations. We give guidelines on proper sample collection and preparation methods, and on performing the analyses and interpreting the results, reporting available user-friendly tools and pipelines.},
  author       = {Valles-Colomer, Mireia and Darzi, Youssef and Vieira-Silva, Sara and Falony, Gwen and Raes, Jeroen and Joossens, Marie},
  issn         = {1873-9946},
  journal      = {JOURNAL OF CROHNS \& COLITIS},
  language     = {eng},
  number       = {6},
  pages        = {735--746},
  title        = {Meta-omics in inflammatory bowel disease research : applications, challenges, and guidelines},
  url          = {http://dx.doi.org/10.1093/ecco-jcc/jjw024},
  volume       = {10},
  year         = {2016},
}

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