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Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

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Abstract
Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m(2) higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m(2) per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.
Keywords
FETAL ORIGINS HYPOTHESIS, ADULT DISEASE, INTRAUTERINE ENVIRONMENT, LATE, ADOLESCENCE, OBESITY, OVERWEIGHT, ADIPOSITY, CHILDHOOD, LENGTH, FAT, birthweight, body mass index, twins

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MLA
Jelenkovic, Aline et al. “Association Between Birthweight and Later Body Mass Index : an Individual-based Pooled Analysis of 27 Twin Cohorts Participating in the CODATwins Project.” INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 46.5 (2017): 1488–1498. Print.
APA
Jelenkovic, A., Yokoyama, Y., Sund, R., Pietilainen, K. H., Hur, Y.-M., Willemsen, G., Bartels, M., et al. (2017). Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 46(5), 1488–1498.
Chicago author-date
Jelenkovic, Aline, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietilainen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, et al. 2017. “Association Between Birthweight and Later Body Mass Index : an Individual-based Pooled Analysis of 27 Twin Cohorts Participating in the CODATwins Project.” International Journal of Epidemiology 46 (5): 1488–1498.
Chicago author-date (all authors)
Jelenkovic, Aline, Yoshie Yokoyama, Reijo Sund, Kirsi H Pietilainen, Yoon-Mi Hur, Gonneke Willemsen, Meike Bartels, Toos CEM van Beijsterveldt, Syuichi Ooki, Kimberly J Saudino, Maria A Stazi, Corrado Fagnani, Cristina D’Ippolito, Tracy L Nelson, Keith E Whitfield, Ariel Knafo-Noam, David Mankuta, Lior Abramson, Kauko Heikkila, Tessa L Cutler, John L Hopper, Jane Wardle, Clare H Llewellyn, Abigail Fisher, Robin P Corley, Brooke M Huibregtse, Catherine Derom, Robert F Vlietinck, Ruth JF Loos, Morten Bjerregaard-Andersen, Henning Beck-Nielsen, Morten Sodemann, Adam D Tarnoki, David LTarnoki, S Alexandra Burt, Kelly L Klump, Juan R Ordonana, Juan F Sanchez-Romera, Lucia Colodro-Conde, Lise Dubois, Michel Boivin, Mara Brendgen, Ginette Dionne, Frank Vitaro, Jennifer R Harris, Lngunn Brandt, Thomas Sevenius Nilsen, Jeffrey M Craig, Richard Saffery, Finn Rasmussen, Per Tynelius, Gombojav Bayasgalan, Danshiitsoodol Narandalai, Claire MA Haworth, Robert Plomin, Fuling Ji, Feng Ning, Zengchang Pang, Esther Rebato, Robert F Krueger, Matt Mcgue, Shandell Pahlen, Dorret I Boomsma, Thorkild IA Sorensen, Jaakko Kaprio, and Karri Silventoinen. 2017. “Association Between Birthweight and Later Body Mass Index : an Individual-based Pooled Analysis of 27 Twin Cohorts Participating in the CODATwins Project.” International Journal of Epidemiology 46 (5): 1488–1498.
Vancouver
1.
Jelenkovic A, Yokoyama Y, Sund R, Pietilainen KH, Hur Y-M, Willemsen G, et al. Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2017;46(5):1488–98.
IEEE
[1]
A. Jelenkovic et al., “Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project,” INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, vol. 46, no. 5, pp. 1488–1498, 2017.
@article{8540730,
  abstract     = {Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. 
Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses. 
Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m(2) higher BMI (P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m(2) per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood. 
Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.},
  author       = {Jelenkovic, Aline and Yokoyama, Yoshie and Sund, Reijo and Pietilainen, Kirsi H and Hur, Yoon-Mi and Willemsen, Gonneke and Bartels, Meike and van Beijsterveldt, Toos CEM and Ooki, Syuichi and Saudino, Kimberly J and Stazi, Maria A and Fagnani, Corrado and D'Ippolito, Cristina and Nelson, Tracy L and Whitfield, Keith E and Knafo-Noam, Ariel and Mankuta, David and Abramson, Lior and Heikkila, Kauko and Cutler, Tessa L and Hopper, John L and Wardle, Jane and Llewellyn, Clare H and Fisher, Abigail and Corley, Robin P and Huibregtse, Brooke M and Derom, Catherine and Vlietinck, Robert F and Loos, Ruth JF and Bjerregaard-Andersen, Morten and Beck-Nielsen, Henning and Sodemann, Morten and Tarnoki, Adam D and LTarnoki, David and Burt, S Alexandra and Klump, Kelly L and Ordonana, Juan R and Sanchez-Romera, Juan F and Colodro-Conde, Lucia and Dubois, Lise and Boivin, Michel and Brendgen, Mara and Dionne, Ginette and Vitaro, Frank and Harris, Jennifer R and Brandt, Lngunn and Nilsen, Thomas Sevenius and Craig, Jeffrey M and Saffery, Richard and Rasmussen, Finn and Tynelius, Per and Bayasgalan, Gombojav and Narandalai, Danshiitsoodol and Haworth, Claire MA and Plomin, Robert and Ji, Fuling and Ning, Feng and Pang, Zengchang and Rebato, Esther and Krueger, Robert F and Mcgue, Matt and Pahlen, Shandell and Boomsma, Dorret I and Sorensen, Thorkild IA and Kaprio, Jaakko and Silventoinen, Karri},
  issn         = {0300-5771},
  journal      = {INTERNATIONAL JOURNAL OF EPIDEMIOLOGY},
  keywords     = {FETAL ORIGINS HYPOTHESIS,ADULT DISEASE,INTRAUTERINE ENVIRONMENT,LATE,ADOLESCENCE,OBESITY,OVERWEIGHT,ADIPOSITY,CHILDHOOD,LENGTH,FAT,birthweight,body mass index,twins},
  language     = {eng},
  number       = {5},
  pages        = {1488--1498},
  title        = {Association between birthweight and later body mass index : an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project},
  url          = {http://dx.doi.org/10.1093/ije/dyx031},
  volume       = {46},
  year         = {2017},
}

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