Advanced search
1 file | 940.03 KB

Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines

Author
Organization
Abstract
Thiouracil (TU), synthesized for its thyroid-regulating capacities and alternatively misused in livestock for its weight-gaining effects, is acknowledged to have an endogenous origin. Discrimination between low-level abuse and endogenous occurrence is challenging and unexplored in an experimental setting. Therefore, cows (n = 16) and calves (n = 18) were subjected to a rapeseed-supplemented diet or treated with synthetic Till. Significant higher urinary TU levels were recorded after TU administration (<CC alpha 15 642 mu g L-1) compared to rapeseed supplementation (<CC alpha, 5.8 mu g L-1), however, with overlapping values. TU was not detected in the edible meat; however, concentrations between the CC alpha, and 10 mu g kg(-1) were noted in thyroid tissue of calves and cows following rapeseed supplementation. The latter concentrations were significantly higher in thyroid tissue of calves (22.9-41.8 mu g kg(-1)) and cows (16.9-36.7 mu g kg (-1)) after synthetic TU administration. These results strongly point toward thyroid analysis as a discriminatory tool..
Keywords
ANABOLIC-ANDROGENIC STEROIDS, MASS-SPECTROMETRY, CYANOGENIC GLUCOSIDE, NUTRITIONAL-VALUE, BRASSICA-JUNCEA, GLUCOSINOLATE, EXCRETION, CATTLE, PLANTS, VITRO, thyreostats, natural formation, rapeseed, experimental design

Downloads

    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 940.03 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Wauters, Jella, Lieven Van Meulebroek, E Fichant, P Delahaut, and Lynn Vanhaecke. 2017. “Discrimination Between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue : an in Vivo Study in Young and Adult Bovines.” Journal of Agricultural and Food Chemistry 65 (30): 6231–6239.
APA
Wauters, Jella, Van Meulebroek, L., Fichant, E., Delahaut, P., & Vanhaecke, L. (2017). Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65(30), 6231–6239.
Vancouver
1.
Wauters J, Van Meulebroek L, Fichant E, Delahaut P, Vanhaecke L. Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2017;65(30):6231–9.
MLA
Wauters, Jella, Lieven Van Meulebroek, E Fichant, et al. “Discrimination Between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue : an in Vivo Study in Young and Adult Bovines.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.30 (2017): 6231–6239. Print.
@article{8540653,
  abstract     = {Thiouracil (TU), synthesized for its thyroid-regulating capacities and alternatively misused in livestock for its weight-gaining effects, is acknowledged to have an endogenous origin. Discrimination between low-level abuse and endogenous occurrence is challenging and unexplored in an experimental setting. Therefore, cows (n = 16) and calves (n = 18) were subjected to a rapeseed-supplemented diet or treated with synthetic Till. Significant higher urinary TU levels were recorded after TU administration ({\textlangle}CC alpha 15 642 mu g L-1) compared to rapeseed supplementation ({\textlangle}CC alpha, 5.8 mu g L-1), however, with overlapping values. TU was not detected in the edible meat; however, concentrations between the CC alpha, and 10 mu g kg(-1) were noted in thyroid tissue of calves and cows following rapeseed supplementation. The latter concentrations were significantly higher in thyroid tissue of calves (22.9-41.8 mu g kg(-1)) and cows (16.9-36.7 mu g kg (-1)) after synthetic TU administration. These results strongly point toward thyroid analysis as a discriminatory tool..},
  author       = {Wauters, Jella and Van Meulebroek, Lieven and Fichant, E and Delahaut, P and Vanhaecke, Lynn},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keyword      = {ANABOLIC-ANDROGENIC STEROIDS,MASS-SPECTROMETRY,CYANOGENIC GLUCOSIDE,NUTRITIONAL-VALUE,BRASSICA-JUNCEA,GLUCOSINOLATE,EXCRETION,CATTLE,PLANTS,VITRO,thyreostats,natural formation,rapeseed,experimental design},
  language     = {eng},
  number       = {30},
  pages        = {6231--6239},
  title        = {Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines},
  url          = {http://dx.doi.org/10.1021/acs.jafc.7b01920},
  volume       = {65},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: