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Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines

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Abstract
Thiouracil (TU), synthesized for its thyroid-regulating capacities and alternatively misused in livestock for its weight-gaining effects, is acknowledged to have an endogenous origin. Discrimination between low-level abuse and endogenous occurrence is challenging and unexplored in an experimental setting. Therefore, cows (n = 16) and calves (n = 18) were subjected to a rapeseed-supplemented diet or treated with synthetic Till. Significant higher urinary TU levels were recorded after TU administration (<CC alpha 15 642 mu g L-1) compared to rapeseed supplementation (<CC alpha, 5.8 mu g L-1), however, with overlapping values. TU was not detected in the edible meat; however, concentrations between the CC alpha, and 10 mu g kg(-1) were noted in thyroid tissue of calves and cows following rapeseed supplementation. The latter concentrations were significantly higher in thyroid tissue of calves (22.9-41.8 mu g kg(-1)) and cows (16.9-36.7 mu g kg (-1)) after synthetic TU administration. These results strongly point toward thyroid analysis as a discriminatory tool..
Keywords
ANABOLIC-ANDROGENIC STEROIDS, MASS-SPECTROMETRY, CYANOGENIC GLUCOSIDE, NUTRITIONAL-VALUE, BRASSICA-JUNCEA, GLUCOSINOLATE, EXCRETION, CATTLE, PLANTS, VITRO, thyreostats, natural formation, rapeseed, experimental design

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MLA
Wauters, Jella et al. “Discrimination Between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue : an in Vivo Study in Young and Adult Bovines.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 65.30 (2017): 6231–6239. Print.
APA
Wauters, Jella, Van Meulebroek, L., Fichant, E., Delahaut, P., & Vanhaecke, L. (2017). Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 65(30), 6231–6239.
Chicago author-date
Wauters, Jella, Lieven Van Meulebroek, E Fichant, P Delahaut, and Lynn Vanhaecke. 2017. “Discrimination Between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue : an in Vivo Study in Young and Adult Bovines.” Journal of Agricultural and Food Chemistry 65 (30): 6231–6239.
Chicago author-date (all authors)
Wauters, Jella, Lieven Van Meulebroek, E Fichant, P Delahaut, and Lynn Vanhaecke. 2017. “Discrimination Between Synthetically Administered and Endogenous Thiouracil Based on Monitoring of Urine, Muscle, and Thyroid Tissue : an in Vivo Study in Young and Adult Bovines.” Journal of Agricultural and Food Chemistry 65 (30): 6231–6239.
Vancouver
1.
Wauters J, Van Meulebroek L, Fichant E, Delahaut P, Vanhaecke L. Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2017;65(30):6231–9.
IEEE
[1]
J. Wauters, L. Van Meulebroek, E. Fichant, P. Delahaut, and L. Vanhaecke, “Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines,” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 65, no. 30, pp. 6231–6239, 2017.
@article{8540653,
  abstract     = {Thiouracil (TU), synthesized for its thyroid-regulating capacities and alternatively misused in livestock for its weight-gaining effects, is acknowledged to have an endogenous origin. Discrimination between low-level abuse and endogenous occurrence is challenging and unexplored in an experimental setting. Therefore, cows (n = 16) and calves (n = 18) were subjected to a rapeseed-supplemented diet or treated with synthetic Till. Significant higher urinary TU levels were recorded after TU administration (<CC alpha 15 642 mu g L-1) compared to rapeseed supplementation (<CC alpha, 5.8 mu g L-1), however, with overlapping values. TU was not detected in the edible meat; however, concentrations between the CC alpha, and 10 mu g kg(-1) were noted in thyroid tissue of calves and cows following rapeseed supplementation. The latter concentrations were significantly higher in thyroid tissue of calves (22.9-41.8 mu g kg(-1)) and cows (16.9-36.7 mu g kg (-1)) after synthetic TU administration. These results strongly point toward thyroid analysis as a discriminatory tool..},
  author       = {Wauters, Jella and Van Meulebroek, Lieven and Fichant, E and Delahaut, P and Vanhaecke, Lynn},
  issn         = {0021-8561},
  journal      = {JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY},
  keywords     = {ANABOLIC-ANDROGENIC STEROIDS,MASS-SPECTROMETRY,CYANOGENIC GLUCOSIDE,NUTRITIONAL-VALUE,BRASSICA-JUNCEA,GLUCOSINOLATE,EXCRETION,CATTLE,PLANTS,VITRO,thyreostats,natural formation,rapeseed,experimental design},
  language     = {eng},
  number       = {30},
  pages        = {6231--6239},
  title        = {Discrimination between synthetically administered and endogenous thiouracil based on monitoring of urine, muscle, and thyroid tissue : an in vivo study in young and adult bovines},
  url          = {http://dx.doi.org/10.1021/acs.jafc.7b01920},
  volume       = {65},
  year         = {2017},
}

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