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Barrier-tissue macrophages : functional adaptation to environmental challenges

(2017) NATURE MEDICINE. 23(11). p.1258-1270
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Abstract
Macrophages are found throughout the body, where they have crucial roles in tissue development, homeostasis and remodeling, as well as being sentinels of the innate immune system that can contribute to protective immunity and inflammation. Barrier tissues, such as the intestine, lung, skin and liver, are exposed constantly to the outside world, which places special demands on resident cell populations such as macrophages. Here we review the mounting evidence that although macrophages in different barrier tissues may be derived from distinct progenitors, their highly specific properties are shaped by the local environment, which allows them to adapt precisely to the needs of their anatomical niche. We discuss the properties of macrophages in steady-state barrier tissues, outline the factors that shape their differentiation and behavior and describe how macrophages change during protective immunity and inflammation.
Keywords
REGULATORY T-CELLS, INNATE LYMPHOID-CELLS, ALTERNATIVELY ACTIVATED MACROPHAGES, LUNG INTERSTITIAL MACROPHAGES, INFLAMMATORY DENDRITIC CELLS, MONOCYTE-DERIVED MACROPHAGES, HUMAN INTESTINAL MACROPHAGES, HUMAN ALVEOLAR MACROPHAGES, NEURO-IMMUNE INTERACTIONS, HIGH-DIMENSIONAL ANALYSIS

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Citation

Please use this url to cite or link to this publication:

Chicago
Mowat, Allan Mcl, Charlotte Scott, and Calum C Bain. 2017. “Barrier-tissue Macrophages : Functional Adaptation to Environmental Challenges.” Nature Medicine 23 (11): 1258–1270.
APA
Mowat, A. M., Scott, C., & Bain, C. C. (2017). Barrier-tissue macrophages : functional adaptation to environmental challenges. NATURE MEDICINE, 23(11), 1258–1270.
Vancouver
1.
Mowat AM, Scott C, Bain CC. Barrier-tissue macrophages : functional adaptation to environmental challenges. NATURE MEDICINE. 2017;23(11):1258–70.
MLA
Mowat, Allan Mcl, Charlotte Scott, and Calum C Bain. “Barrier-tissue Macrophages : Functional Adaptation to Environmental Challenges.” NATURE MEDICINE 23.11 (2017): 1258–1270. Print.
@article{8540537,
  abstract     = {Macrophages are found throughout the body, where they have crucial roles in tissue development, homeostasis and remodeling, as well as being sentinels of the innate immune system that can contribute to protective immunity and inflammation. Barrier tissues, such as the intestine, lung, skin and liver, are exposed constantly to the outside world, which places special demands on resident cell populations such as macrophages. Here we review the mounting evidence that although macrophages in different barrier tissues may be derived from distinct progenitors, their highly specific properties are shaped by the local environment, which allows them to adapt precisely to the needs of their anatomical niche. We discuss the properties of macrophages in steady-state barrier tissues, outline the factors that shape their differentiation and behavior and describe how macrophages change during protective immunity and inflammation.},
  author       = {Mowat, Allan Mcl and Scott, Charlotte and Bain, Calum C},
  issn         = {1078-8956},
  journal      = {NATURE MEDICINE},
  keywords     = {REGULATORY T-CELLS,INNATE LYMPHOID-CELLS,ALTERNATIVELY ACTIVATED MACROPHAGES,LUNG INTERSTITIAL MACROPHAGES,INFLAMMATORY DENDRITIC CELLS,MONOCYTE-DERIVED MACROPHAGES,HUMAN INTESTINAL MACROPHAGES,HUMAN ALVEOLAR MACROPHAGES,NEURO-IMMUNE INTERACTIONS,HIGH-DIMENSIONAL ANALYSIS},
  language     = {eng},
  number       = {11},
  pages        = {1258--1270},
  title        = {Barrier-tissue macrophages : functional adaptation to environmental challenges},
  url          = {http://dx.doi.org/10.1038/nm.4430},
  volume       = {23},
  year         = {2017},
}

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