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Connexin-dependent neuroglial networking as a new therapeutic target

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Abstract
Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks. Astrocytes are connected through connexin-based gap junction channels, with brain region specificities, and those networks modulate neuronal activities, such as those involved in sleep-wake cycle, cognitive, or sensory functions. Additionally, astrocyte domains have been involved in neurogenesis and neuronal differentiation during development; they participate in the "tripartite synapse" with both pre-synaptic and post-synaptic neurons by tuning down or up neuronal activities through the control of neuronal synaptic strength. Connexin-based hemichannels are also involved in those regulations of neuronal activities, however, this feature will not be considered in the present review. Furthermore, neuronal processes, transmitting electrical signals to chemical synapses, stringently control astroglial connexin expression, and channel functions. Long-range energy trafficking toward neurons through connexin-coupled astrocytes and plasticity of those networks are hence largely dependent on neuronal activity. Such reciprocal interactions between neurons and astrocyte networks involve neurotransmitters, cytokines, endogenous lipids, and peptides released by neurons but also other brain cell types, including microglial and endothelial cells. Over the past 10 years, knowledge about neuroglial interactions has widened and now includes effects of CNS-targeting drugs such as antidepressants, antipsychotics, psychostimulants, or sedatives drugs as potential modulators of connexin function and thus astrocyte networking activity. In physiological situations, neuroglial networking is consequently resulting from a two-way interaction between astrocyte gap junction-mediated networks and those made by neurons. As both cell types are modulated by CNS drugs we postulate that neuroglial networking may emerge as new therapeutic targets in neurological and psychiatric disorders.
Keywords
astrocyte network, connexin, gap junction, glia, neuroglial interaction, GAP-JUNCTIONAL COMMUNICATION, ASTROCYTE-DIRECTED INACTIVATION, CENTRAL-NERVOUS-SYSTEM, CULTURED ASTROCYTES, GLIAL-CELLS, ASTROGLIAL NETWORKS, CORTICAL ASTROCYTES, SPINAL-CORD, INTERCELLULAR COMMUNICATIONS, GENERAL-ANESTHETICS

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Please use this url to cite or link to this publication:

Chicago
Charvériat, Mathieu, Christian C Naus, Luc Leybaert, Juan C Sáez, and Christian Giaume. 2017. “Connexin-dependent Neuroglial Networking as a New Therapeutic Target.” Frontiers in Cellular Neuroscience 11.
APA
Charvériat, M., Naus, C. C., Leybaert, L., Sáez, J. C., & Giaume, C. (2017). Connexin-dependent neuroglial networking as a new therapeutic target. FRONTIERS IN CELLULAR NEUROSCIENCE, 11.
Vancouver
1.
Charvériat M, Naus CC, Leybaert L, Sáez JC, Giaume C. Connexin-dependent neuroglial networking as a new therapeutic target. FRONTIERS IN CELLULAR NEUROSCIENCE. 2017;11.
MLA
Charvériat, Mathieu et al. “Connexin-dependent Neuroglial Networking as a New Therapeutic Target.” FRONTIERS IN CELLULAR NEUROSCIENCE 11 (2017): n. pag. Print.
@article{8540468,
  abstract     = {Astrocytes and neurons dynamically interact during physiological processes, and it is now widely accepted that they are both organized in plastic and tightly regulated networks. Astrocytes are connected through connexin-based gap junction channels, with brain region specificities, and those networks modulate neuronal activities, such as those involved in sleep-wake cycle, cognitive, or sensory functions. Additionally, astrocyte domains have been involved in neurogenesis and neuronal differentiation during development; they participate in the "tripartite synapse" with both pre-synaptic and post-synaptic neurons by tuning down or up neuronal activities through the control of neuronal synaptic strength. Connexin-based hemichannels are also involved in those regulations of neuronal activities, however, this feature will not be considered in the present review. Furthermore, neuronal processes, transmitting electrical signals to chemical synapses, stringently control astroglial connexin expression, and channel functions. Long-range energy trafficking toward neurons through connexin-coupled astrocytes and plasticity of those networks are hence largely dependent on neuronal activity. Such reciprocal interactions between neurons and astrocyte networks involve neurotransmitters, cytokines, endogenous lipids, and peptides released by neurons but also other brain cell types, including microglial and endothelial cells. Over the past 10 years, knowledge about neuroglial interactions has widened and now includes effects of CNS-targeting drugs such as antidepressants, antipsychotics, psychostimulants, or sedatives drugs as potential modulators of connexin function and thus astrocyte networking activity. In physiological situations, neuroglial networking is consequently resulting from a two-way interaction between astrocyte gap junction-mediated networks and those made by neurons. As both cell types are modulated by CNS drugs we postulate that neuroglial networking may emerge as new therapeutic targets in neurological and psychiatric disorders.},
  articleno    = {174},
  author       = {Charvériat, Mathieu and Naus, Christian C and Leybaert, Luc and Sáez, Juan C and Giaume, Christian},
  issn         = {1662-5102},
  journal      = {FRONTIERS IN CELLULAR NEUROSCIENCE},
  keywords     = {astrocyte network,connexin,gap junction,glia,neuroglial interaction,GAP-JUNCTIONAL COMMUNICATION,ASTROCYTE-DIRECTED INACTIVATION,CENTRAL-NERVOUS-SYSTEM,CULTURED ASTROCYTES,GLIAL-CELLS,ASTROGLIAL NETWORKS,CORTICAL ASTROCYTES,SPINAL-CORD,INTERCELLULAR COMMUNICATIONS,GENERAL-ANESTHETICS},
  language     = {eng},
  pages        = {14},
  title        = {Connexin-dependent neuroglial networking as a new therapeutic target},
  url          = {http://dx.doi.org/10.3389/fncel.2017.00174},
  volume       = {11},
  year         = {2017},
}

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