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Systematic literature review of health-related quality of life in locally-advanced non-small cell lung cancer : has it yet become state-of-the-art?

Lotte van der Weijst (UGent) , Veerle Surmont (UGent) , Wim Schrauwen (UGent) and Yolande Lievens (UGent)
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Abstract
Lung cancer and its treatment have an important impact on the patients' health-related quality-of-life (HRQoL). A systematic literature review of prospective clinical studies published since 2005 and measuring HRQoL in patients with locally-advanced non-small cell lung cancer (LA- NSCLC) was performed. Besides reviewing the HRQoL impact of LA-NSCLC treatment, it critically examined the frequency, methodology and quality of HRQoL data collection and analysis in LA-NSCLC clinical studies. Out of 814 potentially eligible publications, only 27 (representing 19 individual studies) met the inclusion criteria. Eight studies documented an impact on HRQoL. Large variability in use of HRQoL instruments, statistical analysis and methodological quality was observed. Reporting of HRQoL data lacks standardization, but recent initiatives establishing recommendations to standardize the analysis and reporting of HRQoL in cancer trials are expected to address these issues. Overall, more research is needed to evaluate the treatment impact on HRQoL in both clinical trials and daily care.
Keywords
Health-related quality of life, Non-small cell lung cancer, Systematic literature review, ORAL NUTRITIONAL SUPPLEMENTS, FATTY-ACIDS AFFECT, PHASE-III-TRIAL, CLINICAL-TRIALS, CONCURRENT CHEMOTHERAPY, RANDOMIZED-TRIAL, ENDOBRONCHIAL BRACHYTHERAPY, MULTIMODALITY TREATMENT, PROGNOSIS PATIENTS, DOSE-ESCALATION

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Citation

Please use this url to cite or link to this publication:

Chicago
van der Weijst, Lotte, Veerle Surmont, Wim Schrauwen, and Yolande Lievens. 2017. “Systematic Literature Review of Health-related Quality of Life in Locally-advanced Non-small Cell Lung Cancer : Has It yet Become State-of-the-art?” Critical Reviews in Oncology Hematology 119: 40–49.
APA
van der Weijst, L., Surmont, V., Schrauwen, W., & Lievens, Y. (2017). Systematic literature review of health-related quality of life in locally-advanced non-small cell lung cancer : has it yet become state-of-the-art? CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 119, 40–49.
Vancouver
1.
van der Weijst L, Surmont V, Schrauwen W, Lievens Y. Systematic literature review of health-related quality of life in locally-advanced non-small cell lung cancer : has it yet become state-of-the-art? CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY. 2017;119:40–9.
MLA
van der Weijst, Lotte, Veerle Surmont, Wim Schrauwen, et al. “Systematic Literature Review of Health-related Quality of Life in Locally-advanced Non-small Cell Lung Cancer : Has It yet Become State-of-the-art?” CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY 119 (2017): 40–49. Print.
@article{8540467,
  abstract     = {Lung cancer and its treatment have an important impact on the patients' health-related quality-of-life (HRQoL). A systematic literature review of prospective clinical studies published since 2005 and measuring HRQoL in patients with locally-advanced non-small cell lung cancer (LA- NSCLC) was performed. Besides reviewing the HRQoL impact of LA-NSCLC treatment, it critically examined the frequency, methodology and quality of HRQoL data collection and analysis in LA-NSCLC clinical studies. Out of 814 potentially eligible publications, only 27 (representing 19 individual studies) met the inclusion criteria. Eight studies documented an impact on HRQoL. Large variability in use of HRQoL instruments, statistical analysis and methodological quality was observed. Reporting of HRQoL data lacks standardization, but recent initiatives establishing recommendations to standardize the analysis and reporting of HRQoL in cancer trials are expected to address these issues. Overall, more research is needed to evaluate the treatment impact on HRQoL in both clinical trials and daily care.},
  author       = {van der Weijst, Lotte and Surmont, Veerle and Schrauwen, Wim and Lievens, Yolande},
  issn         = {1040-8428},
  journal      = {CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY},
  keyword      = {Health-related quality of life,Non-small cell lung cancer,Systematic literature review,ORAL NUTRITIONAL SUPPLEMENTS,FATTY-ACIDS AFFECT,PHASE-III-TRIAL,CLINICAL-TRIALS,CONCURRENT CHEMOTHERAPY,RANDOMIZED-TRIAL,ENDOBRONCHIAL BRACHYTHERAPY,MULTIMODALITY TREATMENT,PROGNOSIS PATIENTS,DOSE-ESCALATION},
  language     = {eng},
  pages        = {40--49},
  title        = {Systematic literature review of health-related quality of life in locally-advanced non-small cell lung cancer : has it yet become state-of-the-art?},
  url          = {http://dx.doi.org/10.1016/j.critrevonc.2017.09.014},
  volume       = {119},
  year         = {2017},
}

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