Ghent University Academic Bibliography

Advanced

A critical assessment of the therapeutic potential of resveratrol supplements for treating mitochondrial disorders

Boel De Paepe UGent and Rudy Van Coster UGent (2017) NUTRIENTS. 9(9).
abstract
In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential innovative strategies aim to ameliorate mitochondrial function by increasing the total mitochondrial load of tissues and/or to scavenge the excess of reactive oxygen species generated by OXPHOS malfunctioning. In this respect, resveratrol, a compound that conveniently combines mitogenetic with antioxidant activities and, as a bonus, possesses anti-apoptotic properties, has come forward as a promising nutraceutical. We review the scientific evidence gathered so far through experiments in both in vitro and in vivo systems, evaluating the therapeutic effect that resveratrol is expected to generate in mitochondrial patients. The obtained results are encouraging, but clearly show that achieving normalization of OXPHOS function with this strategy alone could prove to be an unattainable goal.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
mitochondrial biogenesis, mitochondrial disorders, oxidative phosphorylation, resveratrol, RESPIRATORY-CHAIN, COMPLEX I, OXIDATIVE STRESS, DNA MUTATIONS, PGC-1-ALPHA, ACTIVATION, CELLS, DISEASE, SIRT1, DEFICIENCY
journal title
NUTRIENTS
Nutrients
volume
9
issue
9
article number
1017
pages
10 pages
Web of Science type
Review
Web of Science id
000411973200100
ISSN
2072-6643
DOI
10.3390/nu9091017
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8540153
handle
http://hdl.handle.net/1854/LU-8540153
date created
2017-12-04 13:24:15
date last changed
2017-12-11 12:24:24
@article{8540153,
  abstract     = {In human cells, mitochondria provide the largest part of cellular energy in the form of adenosine triphosphate generated by the process of oxidative phosphorylation (OXPHOS). Impaired OXPHOS activity leads to a heterogeneous group of inherited diseases for which therapeutic options today remain very limited. Potential innovative strategies aim to ameliorate mitochondrial function by increasing the total mitochondrial load of tissues and/or to scavenge the excess of reactive oxygen species generated by OXPHOS malfunctioning. In this respect, resveratrol, a compound that conveniently combines mitogenetic with antioxidant activities and, as a bonus, possesses anti-apoptotic properties, has come forward as a promising nutraceutical. We review the scientific evidence gathered so far through experiments in both in vitro and in vivo systems, evaluating the therapeutic effect that resveratrol is expected to generate in mitochondrial patients. The obtained results are encouraging, but clearly show that achieving normalization of OXPHOS function with this strategy alone could prove to be an unattainable goal.},
  articleno    = {1017},
  author       = {De Paepe, Boel and Van Coster, Rudy},
  issn         = {2072-6643},
  journal      = {NUTRIENTS},
  keyword      = {mitochondrial biogenesis,mitochondrial disorders,oxidative phosphorylation,resveratrol,RESPIRATORY-CHAIN,COMPLEX I,OXIDATIVE STRESS,DNA MUTATIONS,PGC-1-ALPHA,ACTIVATION,CELLS,DISEASE,SIRT1,DEFICIENCY},
  language     = {eng},
  number       = {9},
  pages        = {10},
  title        = {A critical assessment of the therapeutic potential of resveratrol supplements for treating mitochondrial disorders},
  url          = {http://dx.doi.org/10.3390/nu9091017},
  volume       = {9},
  year         = {2017},
}

Chicago
De Paepe, Boel, and Rudy Van Coster. 2017. “A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders.” Nutrients 9 (9).
APA
De Paepe, Boel, & Van Coster, R. (2017). A critical assessment of the therapeutic potential of resveratrol supplements for treating mitochondrial disorders. NUTRIENTS, 9(9).
Vancouver
1.
De Paepe B, Van Coster R. A critical assessment of the therapeutic potential of resveratrol supplements for treating mitochondrial disorders. NUTRIENTS. 2017;9(9).
MLA
De Paepe, Boel, and Rudy Van Coster. “A Critical Assessment of the Therapeutic Potential of Resveratrol Supplements for Treating Mitochondrial Disorders.” NUTRIENTS 9.9 (2017): n. pag. Print.