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A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes

(2017) NATURE IMMUNOLOGY. 18(12). p.1310-1320
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Abstract
The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite (HDM)-induced experimental asthma by modulating lung innate immune cells. Specifically, infection with MuHV-4 caused the replacement of resident alveolar macrophages (AMs) by monocytes with regulatory functions. Monocyte-derived AMs blocked the ability of dendritic cells to trigger a HDM-specific response by the T(H)2 subset of helper T cells. Our results indicate that replacement of embryonic AMs by regulatory monocytes is a major mechanism underlying the long-term training of lung immunity after infection.
Keywords
DUST MITE ALLERGEN, AGE-SPECIFIC PREVALENCE, BARR-VIRUS INFECTION, HUMAN, IMMUNE-SYSTEM, DENDRITIC CELLS, HYGIENE HYPOTHESIS, FETAL MONOCYTES, GM-CSF, INFLAMMATION, INDUCTION

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Citation

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MLA
Machiels, Bénédicte, Mickael Dourcy, Xue Xiao, et al. “A Gammaherpesvirus Provides Protection Against Allergic Asthma by Inducing the Replacement of Resident Alveolar Macrophages with Regulatory Monocytes.” NATURE IMMUNOLOGY 18.12 (2017): 1310–1320. Print.
APA
Machiels, Bénédicte, Dourcy, M., Xiao, X., Javaux, J., Mesnil, C., Sabatel, C., Desmecht, D., et al. (2017). A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. NATURE IMMUNOLOGY, 18(12), 1310–1320.
Chicago author-date
Machiels, Bénédicte, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil, Catherine Sabatel, Daniel Desmecht, et al. 2017. “A Gammaherpesvirus Provides Protection Against Allergic Asthma by Inducing the Replacement of Resident Alveolar Macrophages with Regulatory Monocytes.” Nature Immunology 18 (12): 1310–1320.
Chicago author-date (all authors)
Machiels, Bénédicte, Mickael Dourcy, Xue Xiao, Justine Javaux, Claire Mesnil, Catherine Sabatel, Daniel Desmecht, François Lallemand, Philippe Martinive, Hamida Hammad, Martin Guilliams, Benjamin Dewals, Alain Vanderplasschen, Bart Lambrecht, Fabrice Bureau, and Laurent Gillet. 2017. “A Gammaherpesvirus Provides Protection Against Allergic Asthma by Inducing the Replacement of Resident Alveolar Macrophages with Regulatory Monocytes.” Nature Immunology 18 (12): 1310–1320.
Vancouver
1.
Machiels B, Dourcy M, Xiao X, Javaux J, Mesnil C, Sabatel C, et al. A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes. NATURE IMMUNOLOGY. 2017;18(12):1310–20.
IEEE
[1]
B. Machiels et al., “A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes,” NATURE IMMUNOLOGY, vol. 18, no. 12, pp. 1310–1320, 2017.
@article{8539883,
  abstract     = {The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite (HDM)-induced experimental asthma by modulating lung innate immune cells. Specifically, infection with MuHV-4 caused the replacement of resident alveolar macrophages (AMs) by monocytes with regulatory functions. Monocyte-derived AMs blocked the ability of dendritic cells to trigger a HDM-specific response by the T(H)2 subset of helper T cells. Our results indicate that replacement of embryonic AMs by regulatory monocytes is a major mechanism underlying the long-term training of lung immunity after infection.},
  author       = {Machiels, Bénédicte and Dourcy, Mickael and Xiao, Xue and Javaux, Justine and Mesnil, Claire and Sabatel, Catherine and Desmecht, Daniel and Lallemand, François and Martinive, Philippe and Hammad, Hamida and Guilliams, Martin and Dewals, Benjamin and Vanderplasschen, Alain and Lambrecht, Bart and Bureau, Fabrice and Gillet, Laurent},
  issn         = {1529-2908},
  journal      = {NATURE IMMUNOLOGY},
  keywords     = {DUST MITE ALLERGEN,AGE-SPECIFIC PREVALENCE,BARR-VIRUS INFECTION,HUMAN,IMMUNE-SYSTEM,DENDRITIC CELLS,HYGIENE HYPOTHESIS,FETAL MONOCYTES,GM-CSF,INFLAMMATION,INDUCTION},
  language     = {eng},
  number       = {12},
  pages        = {1310--1320},
  title        = {A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes},
  url          = {http://dx.doi.org/10.1038/ni.3857},
  volume       = {18},
  year         = {2017},
}

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