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Reslizumab in eosinophilic asthma : a review

(2017) DRUGS. 77(7). p.777-784
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Abstract
Reslizumab (Cinqaero (R); Cinqair (R)) is a humanized monoclonal antibody against interleukin-5 (IL-5), a cytokine mediator of eosinophilic airway inflammation. Reslizumab is indicated as an add-on treatment for severe eosinophilic asthma in adults, on the basis of data from the BREATH phase III clinical trial programme. In three double-blind BREATH studies of up to 52 weeks' duration, adding intravenous reslizumab (3 mg/kg, once every 4 weeks) to the current asthma therapy of patients (aged 12-75 years) with eosinophilic asthma inadequately controlled with inhaled corticosteroids resulted in significant reductions in clinical asthma exacerbation frequency and significant improvements in lung function, asthma control and health-related quality of life relative to adding placebo. Pooled data from the two trials of 52 weeks' duration indicated similar benefits with reslizumab across various patient subgroups, including patients with severe eosinophilic asthma. Reslizumab was generally well tolerated, with very few recipients experiencing severe or serious treatment-related adverse events. Moreover, in an open-label extension study, continued use of reslizumab for up to 2 years was associated with durable lung function benefit, without any new tolerability concerns. Thus, intravenous reslizumab extends the valuable add-on treatment options for adults with severe eosinophilic asthma inadequately controlled with standard therapies.
Keywords
ELEVATED BLOOD EOSINOPHILS, HUMAN INTERLEUKIN-5, SCH 55700, MEPOLIZUMAB, ANTIBODY, PHASE-3, COUNTS, RANGE

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MLA
Deeks, Emma D., and Guy Brusselle. “Reslizumab in Eosinophilic Asthma : A Review.” DRUGS, vol. 77, no. 7, 2017, pp. 777–84, doi:10.1007/s40265-017-0740-2.
APA
Deeks, E. D., & Brusselle, G. (2017). Reslizumab in eosinophilic asthma : a review. DRUGS, 77(7), 777–784. https://doi.org/10.1007/s40265-017-0740-2
Chicago author-date
Deeks, Emma D, and Guy Brusselle. 2017. “Reslizumab in Eosinophilic Asthma : A Review.” DRUGS 77 (7): 777–84. https://doi.org/10.1007/s40265-017-0740-2.
Chicago author-date (all authors)
Deeks, Emma D, and Guy Brusselle. 2017. “Reslizumab in Eosinophilic Asthma : A Review.” DRUGS 77 (7): 777–784. doi:10.1007/s40265-017-0740-2.
Vancouver
1.
Deeks ED, Brusselle G. Reslizumab in eosinophilic asthma : a review. DRUGS. 2017;77(7):777–84.
IEEE
[1]
E. D. Deeks and G. Brusselle, “Reslizumab in eosinophilic asthma : a review,” DRUGS, vol. 77, no. 7, pp. 777–784, 2017.
@article{8539293,
  abstract     = {{Reslizumab (Cinqaero (R); Cinqair (R)) is a humanized monoclonal antibody against interleukin-5 (IL-5), a cytokine mediator of eosinophilic airway inflammation. Reslizumab is indicated as an add-on treatment for severe eosinophilic asthma in adults, on the basis of data from the BREATH phase III clinical trial programme. In three double-blind BREATH studies of up to 52 weeks' duration, adding intravenous reslizumab (3 mg/kg, once every 4 weeks) to the current asthma therapy of patients (aged 12-75 years) with eosinophilic asthma inadequately controlled with inhaled corticosteroids resulted in significant reductions in clinical asthma exacerbation frequency and significant improvements in lung function, asthma control and health-related quality of life relative to adding placebo. Pooled data from the two trials of 52 weeks' duration indicated similar benefits with reslizumab across various patient subgroups, including patients with severe eosinophilic asthma. Reslizumab was generally well tolerated, with very few recipients experiencing severe or serious treatment-related adverse events. Moreover, in an open-label extension study, continued use of reslizumab for up to 2 years was associated with durable lung function benefit, without any new tolerability concerns. Thus, intravenous reslizumab extends the valuable add-on treatment options for adults with severe eosinophilic asthma inadequately controlled with standard therapies.}},
  author       = {{Deeks, Emma D and Brusselle, Guy}},
  issn         = {{0012-6667}},
  journal      = {{DRUGS}},
  keywords     = {{ELEVATED BLOOD EOSINOPHILS,HUMAN INTERLEUKIN-5,SCH 55700,MEPOLIZUMAB,ANTIBODY,PHASE-3,COUNTS,RANGE}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{777--784}},
  title        = {{Reslizumab in eosinophilic asthma : a review}},
  url          = {{http://doi.org/10.1007/s40265-017-0740-2}},
  volume       = {{77}},
  year         = {{2017}},
}

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