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ERS technical standard on bronchial challenge testing : general considerations and performance of methacholine challenge tests

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Abstract
This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.
Keywords
INHALATION PROVOCATION TESTS, INDUCED BRONCHOCONSTRICTION, AIRWAY, RESPONSES, CYSTIC-FIBROSIS, LUNG-FUNCTION, INHALED METHACHOLINE, ASTHMATIC-CHILDREN, HIGH PREVALENCE, PARTICLE-SIZE, HISTAMINE

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Citation

Please use this url to cite or link to this publication:

Chicago
Coates, Allan L, Jack Wanger, Donald W Cockcroft, Bruce H Culver, Kai-Håkon Carlsen, Zuzana Diamant, Gail Gauvreau, et al. 2017. “ERS Technical Standard on Bronchial Challenge Testing : General Considerations and Performance of Methacholine Challenge Tests.” European Respiratory Journal 49 (5).
APA
Coates, A. L., Wanger, J., Cockcroft, D. W., Culver, B. H., Carlsen, K.-H., Diamant, Z., Gauvreau, G., et al. (2017). ERS technical standard on bronchial challenge testing : general considerations and performance of methacholine challenge tests. EUROPEAN RESPIRATORY JOURNAL, 49(5).
Vancouver
1.
Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, et al. ERS technical standard on bronchial challenge testing : general considerations and performance of methacholine challenge tests. EUROPEAN RESPIRATORY JOURNAL. 2017;49(5).
MLA
Coates, Allan L, Jack Wanger, Donald W Cockcroft, et al. “ERS Technical Standard on Bronchial Challenge Testing : General Considerations and Performance of Methacholine Challenge Tests.” EUROPEAN RESPIRATORY JOURNAL 49.5 (2017): n. pag. Print.
@article{8539174,
  abstract     = {This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20\% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20\% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.},
  articleno    = {1601526},
  author       = {Coates, Allan L and Wanger, Jack and Cockcroft, Donald W and Culver, Bruce H and Carlsen, Kai-H{\aa}kon and Diamant, Zuzana and Gauvreau, Gail and Hall, Graham L and Hallstrand, Teal S and Horvath, Ildiko and de Jongh, Frans HC and Joos, Guy and Kaminsky, David A and Laube, Beth L and Leuppi, Joerg D and Sterk, Peter J},
  issn         = {0903-1936},
  journal      = {EUROPEAN RESPIRATORY JOURNAL},
  keyword      = {INHALATION PROVOCATION TESTS,INDUCED BRONCHOCONSTRICTION,AIRWAY,RESPONSES,CYSTIC-FIBROSIS,LUNG-FUNCTION,INHALED METHACHOLINE,ASTHMATIC-CHILDREN,HIGH PREVALENCE,PARTICLE-SIZE,HISTAMINE},
  language     = {eng},
  number       = {5},
  pages        = {17},
  title        = {ERS technical standard on bronchial challenge testing : general considerations and performance of methacholine challenge tests},
  url          = {http://dx.doi.org/10.1183/13993003.01526-2016},
  volume       = {49},
  year         = {2017},
}

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