Advanced search
1 file | 366.00 KB

Staphylococcus aureus enterotoxin sensitization is associated with allergic poly-sensitization and allergic multimorbidity in adolescents

(2017) ALLERGY. 72(10). p.1548-1555
Author
Organization
Abstract
Background: Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromso Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear. Objective: To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization. Methods: A cross-sectional study of a school-based cohort in late adolescence (aged 18-19 years: The Tromso Study Fit Futures 2). Self-reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens. Results: A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly-sensitization to food and inhalant allergens. SE-sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1-118.4) compared to non-SE-sensitized participants (18.0 kU(A)/L, IQR 5.5-48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity. Conclusion: Sensitization to SEs may play a role in the development of allergen poly-sensitization and allergic multimorbidity.
Keywords
Allergic disease, Allergic multimorbidity, Poly-sensitization, Staphylococcus aureus, Staphylococcus aureus Enterotoxins, ATOPIC-DERMATITIS, NASAL CARRIAGE, CHRONIC RHINOSINUSITIS, IGE SENSITIZATION, BIRTH COHORTS, ASTHMA, MEDALL, POPULATION, RHINITIS, COMORBIDITY

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 366.00 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Sørensen, M, C Klingenberg, M Wickman, JUE Sollid, A-S Furberg, Claus Bachert, and J Bousquet. 2017. “Staphylococcus Aureus Enterotoxin Sensitization Is Associated with Allergic Poly-sensitization and Allergic Multimorbidity in Adolescents.” Allergy 72 (10): 1548–1555.
APA
Sørensen, M., Klingenberg, C., Wickman, M., Sollid, J., Furberg, A.-S., Bachert, C., & Bousquet, J. (2017). Staphylococcus aureus enterotoxin sensitization is associated with allergic poly-sensitization and allergic multimorbidity in adolescents. ALLERGY, 72(10), 1548–1555.
Vancouver
1.
Sørensen M, Klingenberg C, Wickman M, Sollid J, Furberg A-S, Bachert C, et al. Staphylococcus aureus enterotoxin sensitization is associated with allergic poly-sensitization and allergic multimorbidity in adolescents. ALLERGY. 2017;72(10):1548–55.
MLA
Sørensen, M et al. “Staphylococcus Aureus Enterotoxin Sensitization Is Associated with Allergic Poly-sensitization and Allergic Multimorbidity in Adolescents.” ALLERGY 72.10 (2017): 1548–1555. Print.
@article{8539092,
  abstract     = {Background: Staphylococcus aureus (S. aureus) carriage and sensitization to S. aureus enterotoxins (SEs) have been associated with allergic diseases. From the Tromso Study Fit Futures 2, we have previously shown an association between S. aureus carriage and severe allergic disease and allergic multimorbidity. However, the role of S. aureus carriage and SE sensitization on allergic multimorbidity and allergic sensitization is unclear. 
Objective: To study associations of both nasal S. aureus carriage and SE sensitization to allergic disease and allergic sensitization. 
Methods: A cross-sectional study of a school-based cohort in late adolescence (aged 18-19 years: The Tromso Study Fit Futures 2). Self-reported allergic diseases were assessed using the Mechanisms of the Development of ALLergy questionnaire (MeDALL). Participants were tested for nasal S. aureus carriage, serum total IgE and specific IgE to SEs, and food and inhalant allergens. 
Results: A total of 868 participants were studied. Sensitization to at least one food or inhalant allergen was found in 319 of 765 (41.7%), and to at least one SE in 173 of 656 (26.2%) participants. SE sensitization, but not S. aureus carriage, was associated with poly-sensitization to food and inhalant allergens. SE-sensitized participants had higher median specific IgE to inhalant allergens (41.4 kUA/L, IQR 10.1-118.4) compared to non-SE-sensitized participants (18.0 kU(A)/L, IQR 5.5-48.6, P=.004), but not to food allergens. SE sensitization was associated with allergic multimorbidity. 
Conclusion: Sensitization to SEs may play a role in the development of allergen poly-sensitization and allergic multimorbidity.},
  author       = {Sørensen, M and Klingenberg, C and Wickman, M and Sollid, JUE and Furberg, A-S and Bachert, Claus and Bousquet, J},
  issn         = {0105-4538},
  journal      = {ALLERGY},
  keywords     = {Allergic disease,Allergic multimorbidity,Poly-sensitization,Staphylococcus aureus,Staphylococcus aureus Enterotoxins,ATOPIC-DERMATITIS,NASAL CARRIAGE,CHRONIC RHINOSINUSITIS,IGE SENSITIZATION,BIRTH COHORTS,ASTHMA,MEDALL,POPULATION,RHINITIS,COMORBIDITY},
  language     = {eng},
  number       = {10},
  pages        = {1548--1555},
  title        = {Staphylococcus aureus enterotoxin sensitization is associated with allergic poly-sensitization and allergic multimorbidity in adolescents},
  url          = {http://dx.doi.org/10.1111/all.13175},
  volume       = {72},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: