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Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool

Lindsey Devisscher (UGent) , Charlotte Scott (UGent) , Sander Lefere (UGent) , Sarah Raevens (UGent) , Eliene Bogaerts (UGent) , Annelies Paridaens (UGent) , Xavier Verhelst (UGent) , Anja Geerts (UGent) , Martin Guilliams (UGent) and Hans Van Vlierberghe (UGent)
(2017) CELLULAR IMMUNOLOGY. 322. p.74-83
Author
Organization
Abstract
Kupffer cells (KCs) and monocyte-derived macrophages are implicated in non-alcoholic steatohepatitis (NASH) pathogenesis but their functions remain unclear due to the lack of specific markers to distinguish between the different cell types. Additionally, it is unclear if multiple subsets of KCs are present during NASH. Here, we characterized the liver macrophage subsets during methionine/choline deficient (MCD) diet-induced NASH and recovery. We observed a significant reduced contribution of Ly6C(lo)Clec4F(+)Tim4(+) KCs to the hepatic macrophage pool in MCD fed mice, which normalized during recovery. Ly6C(lo)Clec4F(-)Tim4(-) monocyte-derived macrophages increased during MCD feeding and returned to baseline during recovery. Ly6C(lo)Clec4F(+)Tim4(-) monocyte-derived KCs developed during initial recovery but did not self-renew as their numbers were reduced after full recovery. Initial recovery from MCD diet feeding was further characterized by increased proportions of Ki-67(+) proliferating KCs. In conclusion, the hepatic macrophage pool undergoes substantial albeit transient changes during NASH and recovery, with the KC pool being maintained by proliferation and differentiation of short-lived monocyte-derived KCs.
Keywords
Kupffer cell, Monocyte, Macrophage, Non-alcoholic steatohepatitis, CHOLINE-DEFICIENT DIET, HEMATOPOIETIC STEM-CELLS, KUPFFER CELLS, HEPATIC STEATOSIS, INSULIN-RESISTANCE, DISEASE, MICE, ACTIVATION, MONOCYTES, FIBROSIS

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MLA
Devisscher, Lindsey, et al. “Non-Alcoholic Steatohepatitis Induces Transient Changes within the Liver Macrophage Pool.” CELLULAR IMMUNOLOGY, vol. 322, 2017, pp. 74–83, doi:10.1016/j.cellimm.2017.10.006.
APA
Devisscher, L., Scott, C., Lefere, S., Raevens, S., Bogaerts, E., Paridaens, A., … Van Vlierberghe, H. (2017). Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool. CELLULAR IMMUNOLOGY, 322, 74–83. https://doi.org/10.1016/j.cellimm.2017.10.006
Chicago author-date
Devisscher, Lindsey, Charlotte Scott, Sander Lefere, Sarah Raevens, Eliene Bogaerts, Annelies Paridaens, Xavier Verhelst, Anja Geerts, Martin Guilliams, and Hans Van Vlierberghe. 2017. “Non-Alcoholic Steatohepatitis Induces Transient Changes within the Liver Macrophage Pool.” CELLULAR IMMUNOLOGY 322: 74–83. https://doi.org/10.1016/j.cellimm.2017.10.006.
Chicago author-date (all authors)
Devisscher, Lindsey, Charlotte Scott, Sander Lefere, Sarah Raevens, Eliene Bogaerts, Annelies Paridaens, Xavier Verhelst, Anja Geerts, Martin Guilliams, and Hans Van Vlierberghe. 2017. “Non-Alcoholic Steatohepatitis Induces Transient Changes within the Liver Macrophage Pool.” CELLULAR IMMUNOLOGY 322: 74–83. doi:10.1016/j.cellimm.2017.10.006.
Vancouver
1.
Devisscher L, Scott C, Lefere S, Raevens S, Bogaerts E, Paridaens A, et al. Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool. CELLULAR IMMUNOLOGY. 2017;322:74–83.
IEEE
[1]
L. Devisscher et al., “Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool,” CELLULAR IMMUNOLOGY, vol. 322, pp. 74–83, 2017.
@article{8538689,
  abstract     = {{Kupffer cells (KCs) and monocyte-derived macrophages are implicated in non-alcoholic steatohepatitis (NASH) pathogenesis but their functions remain unclear due to the lack of specific markers to distinguish between the different cell types. Additionally, it is unclear if multiple subsets of KCs are present during NASH. Here, we characterized the liver macrophage subsets during methionine/choline deficient (MCD) diet-induced NASH and recovery. We observed a significant reduced contribution of Ly6C(lo)Clec4F(+)Tim4(+) KCs to the hepatic macrophage pool in MCD fed mice, which normalized during recovery. Ly6C(lo)Clec4F(-)Tim4(-) monocyte-derived macrophages increased during MCD feeding and returned to baseline during recovery. Ly6C(lo)Clec4F(+)Tim4(-) monocyte-derived KCs developed during initial recovery but did not self-renew as their numbers were reduced after full recovery. Initial recovery from MCD diet feeding was further characterized by increased proportions of Ki-67(+) proliferating KCs. In conclusion, the hepatic macrophage pool undergoes substantial albeit transient changes during NASH and recovery, with the KC pool being maintained by proliferation and differentiation of short-lived monocyte-derived KCs.}},
  author       = {{Devisscher, Lindsey and Scott, Charlotte and Lefere, Sander and Raevens, Sarah and Bogaerts, Eliene and Paridaens, Annelies and Verhelst, Xavier and Geerts, Anja and Guilliams, Martin and Van Vlierberghe, Hans}},
  issn         = {{0008-8749}},
  journal      = {{CELLULAR IMMUNOLOGY}},
  keywords     = {{Kupffer cell,Monocyte,Macrophage,Non-alcoholic steatohepatitis,CHOLINE-DEFICIENT DIET,HEMATOPOIETIC STEM-CELLS,KUPFFER CELLS,HEPATIC STEATOSIS,INSULIN-RESISTANCE,DISEASE,MICE,ACTIVATION,MONOCYTES,FIBROSIS}},
  language     = {{eng}},
  pages        = {{74--83}},
  title        = {{Non-alcoholic steatohepatitis induces transient changes within the liver macrophage pool}},
  url          = {{http://dx.doi.org/10.1016/j.cellimm.2017.10.006}},
  volume       = {{322}},
  year         = {{2017}},
}
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