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Role of HIV exposure and infection in relation to neonatal GBS disease and rectovaginal GBS carriage : a systematic review and meta-analysis

Piet Cools UGent, Janneke HHM van de Wijgert, Vicky Jespers, Tania Crucitti, Eduard J Sanders, Hans Verstraelen UGent and Mario Vaneechoutte UGent (2017) SCIENTIFIC REPORTS. 7.
abstract
Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most important risk factor for GBS neonatal disease. We searched Pubmed, Embase, and Web of Science for studies assessing the association between neonatal GBS disease and HIV-status of the mother and studies that assessed the association between rectovaginal GBS colonization and HIV status in women. HIV-exposed uninfected neonates were more than twice as likely to have neonatal GBS disease compared to unexposed neonates. HIV-exposed neonates were not at increased risk for early-onset neonatal disease, but were 4.43 times more likely to have late-onset neonatal GBS disease. There was no significant association between HIV infection status and rectovaginal GBS carriage. Public health interventions preventing neonatal GBS disease are urgently needed for the increasing group of HIV-exposed neonates. A framework integrating and explaining our findings highlights opportunities for the clinical practice and global health policy to prevent disease. Well-designed studies should clarify the relation between HIV-status and GBS carriage.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
GROUP-B STREPTOCOCCUS, LOW-BIRTH-WEIGHT, INTESTINAL, BACTERIAL-COLONIZATION, PREGNANT-WOMEN, RISK-FACTORS, PREMATURE-INFANTS, HUMAN-MILK, UNINFECTED CHILDREN, VAGINAL MICROBIOTA, MATERNAL ANTIBODY
journal title
SCIENTIFIC REPORTS
Sci Rep
volume
7
article number
13820
pages
13 pages
Web of Science type
Review
Web of Science id
000413400500095
ISSN
2045-2322
DOI
10.1038/s41598-017-13218-1
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8538644
handle
http://hdl.handle.net/1854/LU-8538644
date created
2017-11-23 08:03:30
date last changed
2017-11-23 08:12:14
@article{8538644,
  abstract     = {Streptococcus agalactiae (GBS) is the leading cause worldwide of neonatal sepsis. We sought to assess to which extent HIV exposure of neonates is associated with GBS neonatal disease. Furthermore, we assessed to which extent HIV infection in women is associated with maternal rectovaginal GBS carriage, the single most important risk factor for GBS neonatal disease. We searched Pubmed, Embase, and Web of Science for studies assessing the association between neonatal GBS disease and HIV-status of the mother and studies that assessed the association between rectovaginal GBS colonization and HIV status in women. HIV-exposed uninfected neonates were more than twice as likely to have neonatal GBS disease compared to unexposed neonates. HIV-exposed neonates were not at increased risk for early-onset neonatal disease, but were 4.43 times more likely to have late-onset neonatal GBS disease. There was no significant association between HIV infection status and rectovaginal GBS carriage. Public health interventions preventing neonatal GBS disease are urgently needed for the increasing group of HIV-exposed neonates. A framework integrating and explaining our findings highlights opportunities for the clinical practice and global health policy to prevent disease. Well-designed studies should clarify the relation between HIV-status and GBS carriage.},
  articleno    = {13820},
  author       = {Cools, Piet and van de Wijgert, Janneke HHM and Jespers, Vicky and Crucitti, Tania and Sanders, Eduard J and Verstraelen, Hans and Vaneechoutte, Mario},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {GROUP-B STREPTOCOCCUS,LOW-BIRTH-WEIGHT,INTESTINAL,BACTERIAL-COLONIZATION,PREGNANT-WOMEN,RISK-FACTORS,PREMATURE-INFANTS,HUMAN-MILK,UNINFECTED CHILDREN,VAGINAL MICROBIOTA,MATERNAL ANTIBODY},
  language     = {eng},
  pages        = {13},
  title        = {Role of HIV exposure and infection in relation to neonatal GBS disease and rectovaginal GBS carriage : a systematic review and meta-analysis},
  url          = {http://dx.doi.org/10.1038/s41598-017-13218-1},
  volume       = {7},
  year         = {2017},
}

Chicago
Cools, Piet, Janneke HHM van de Wijgert, Vicky Jespers, Tania Crucitti, Eduard J Sanders, Hans Verstraelen, and Mario Vaneechoutte. 2017. “Role of HIV Exposure and Infection in Relation to Neonatal GBS Disease and Rectovaginal GBS Carriage : a Systematic Review and Meta-analysis.” Scientific Reports 7.
APA
Cools, Piet, van de Wijgert, J. H., Jespers, V., Crucitti, T., Sanders, E. J., Verstraelen, H., & Vaneechoutte, M. (2017). Role of HIV exposure and infection in relation to neonatal GBS disease and rectovaginal GBS carriage : a systematic review and meta-analysis. SCIENTIFIC REPORTS, 7.
Vancouver
1.
Cools P, van de Wijgert JH, Jespers V, Crucitti T, Sanders EJ, Verstraelen H, et al. Role of HIV exposure and infection in relation to neonatal GBS disease and rectovaginal GBS carriage : a systematic review and meta-analysis. SCIENTIFIC REPORTS. 2017;7.
MLA
Cools, Piet, Janneke HHM van de Wijgert, Vicky Jespers, et al. “Role of HIV Exposure and Infection in Relation to Neonatal GBS Disease and Rectovaginal GBS Carriage : a Systematic Review and Meta-analysis.” SCIENTIFIC REPORTS 7 (2017): n. pag. Print.