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Dysfunction of large-scale brain networks in Schizophrenia : a meta-analysis of resting-state functional connectivity

(2018) SCHIZOPHRENIA BULLETIN. 44(1). p.168-181
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Abstract
Schizophrenia is a complex mental disorder with disorganized communication among large-scale brain networks, as demonstrated by impaired resting-state functional connectivity (rsFC). Individual rsFC studies, however, vary greatly in their methods and findings. We searched for consistent patterns of network dysfunction in schizophrenia by using a coordinate-based meta-analysis. Fifty-six seed-based voxel-wise rsFC datasets from 52 publications (2115 patients and 2297 healthy controls) were included in this meta-analysis. Then, coordinates of seed regions of interest (ROI) and between-group effects were extracted and coded. Seed ROIs were categorized into seed networks by their location within an a priori template. Multilevel kernel density analysis was used to identify brain networks in which schizophrenia was linked to hyper-connectivity or hypo-connectivity with each a priori network. Our results showed that schizophrenia was characterized by hypo-connectivity within the default network (DN, self-related thought), affective network (AN, emotion processing), ventral attention network (VAN, processing of salience), thalamus network (TN, gating information) and somatosensory network (SS, involved in sensory and auditory perception). Additionally, hypo-connectivity between the VAN and TN, VAN and DN, VAN and frontoparietal network (FN, external goal-directed regulation), FN and TN, and FN and DN were found in schizophrenia. Finally, the only instance of hyper-connectivity in schizophrenia was observed between the AN and VAN. Our meta-analysis motivates an empirical foundation for a disconnected large-scale brain networks model of schizophrenia in which the salience processing network (VAN) plays the core role, and its imbalanced communication with other functional networks may underlie the core difficulty of patients to differentiate self-representation (inner world) and environmental salience processing (outside world).
Keywords
schizophrenia, meta-analysis, brain networks, resting-state, salience network, disconnected model, DEFAULT-MODE NETWORK, DORSOLATERAL PREFRONTAL CORTEX, BIPOLAR DISORDER, ANATOMICAL CONNECTIVITY, INTRINSIC CONNECTIVITY, FRONTOPARIETAL CONTROL, SYNAPTIC PLASTICITY, GLOBAL SIGNAL, HESCHLS GYRUS, WHOLE-BRAIN

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Citation

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MLA
Dong, Debo, et al. “Dysfunction of Large-Scale Brain Networks in Schizophrenia : A Meta-Analysis of Resting-State Functional Connectivity.” SCHIZOPHRENIA BULLETIN, vol. 44, no. 1, Oxford University Press (OUP), 2018, pp. 168–81.
APA
Dong, D., Wang, Y., Chang, X., Luo, C., & Yao, D. (2018). Dysfunction of large-scale brain networks in Schizophrenia : a meta-analysis of resting-state functional connectivity. SCHIZOPHRENIA BULLETIN, 44(1), 168–181.
Chicago author-date
Dong, Debo, Yulin Wang, Xuebin Chang, Cheng Luo, and Dezhong Yao. 2018. “Dysfunction of Large-Scale Brain Networks in Schizophrenia : A Meta-Analysis of Resting-State Functional Connectivity.” SCHIZOPHRENIA BULLETIN 44 (1): 168–81.
Chicago author-date (all authors)
Dong, Debo, Yulin Wang, Xuebin Chang, Cheng Luo, and Dezhong Yao. 2018. “Dysfunction of Large-Scale Brain Networks in Schizophrenia : A Meta-Analysis of Resting-State Functional Connectivity.” SCHIZOPHRENIA BULLETIN 44 (1): 168–181.
Vancouver
1.
Dong D, Wang Y, Chang X, Luo C, Yao D. Dysfunction of large-scale brain networks in Schizophrenia : a meta-analysis of resting-state functional connectivity. SCHIZOPHRENIA BULLETIN. 2018;44(1):168–81.
IEEE
[1]
D. Dong, Y. Wang, X. Chang, C. Luo, and D. Yao, “Dysfunction of large-scale brain networks in Schizophrenia : a meta-analysis of resting-state functional connectivity,” SCHIZOPHRENIA BULLETIN, vol. 44, no. 1, pp. 168–181, 2018.
@article{8537944,
  abstract     = {Schizophrenia is a complex mental disorder with disorganized communication among large-scale brain networks, as demonstrated by impaired resting-state functional connectivity (rsFC). Individual rsFC studies, however, vary greatly in their methods and findings. We searched for consistent patterns of network dysfunction in schizophrenia by using a coordinate-based meta-analysis. Fifty-six seed-based voxel-wise rsFC datasets from 52 publications (2115 patients and 2297 healthy controls) were included in this meta-analysis. Then, coordinates of seed regions of interest (ROI) and between-group effects were extracted and coded. Seed ROIs were categorized into seed networks by their location within an a priori template. Multilevel kernel density analysis was used to identify brain networks in which schizophrenia was linked to hyper-connectivity or hypo-connectivity with each a priori network. Our results showed that schizophrenia was characterized by hypo-connectivity within the default network (DN, self-related thought), affective network (AN, emotion processing), ventral attention network (VAN, processing of salience), thalamus network (TN, gating information) and somatosensory network (SS, involved in sensory and auditory perception). Additionally, hypo-connectivity between the VAN and TN, VAN and DN, VAN and frontoparietal network (FN, external goal-directed regulation), FN and TN, and FN and DN were found in schizophrenia. Finally, the only instance of hyper-connectivity in schizophrenia was observed between the AN and VAN. Our meta-analysis motivates an empirical foundation for a disconnected large-scale brain networks model of schizophrenia in which the salience processing network (VAN) plays the core role, and its imbalanced communication with other functional networks may underlie the core difficulty of patients to differentiate self-representation (inner world) and environmental salience processing (outside world).},
  author       = {Dong, Debo and Wang, Yulin and Chang, Xuebin and Luo, Cheng and Yao, Dezhong},
  issn         = {0586-7614},
  journal      = {SCHIZOPHRENIA BULLETIN},
  keywords     = {schizophrenia,meta-analysis,brain networks,resting-state,salience network,disconnected model,DEFAULT-MODE NETWORK,DORSOLATERAL PREFRONTAL CORTEX,BIPOLAR DISORDER,ANATOMICAL CONNECTIVITY,INTRINSIC CONNECTIVITY,FRONTOPARIETAL CONTROL,SYNAPTIC PLASTICITY,GLOBAL SIGNAL,HESCHLS GYRUS,WHOLE-BRAIN},
  language     = {eng},
  number       = {1},
  pages        = {168--181},
  publisher    = {Oxford University Press (OUP)},
  title        = {Dysfunction of large-scale brain networks in Schizophrenia : a meta-analysis of resting-state functional connectivity},
  url          = {http://dx.doi.org/10.1093/schbul/sbx034},
  volume       = {44},
  year         = {2018},
}

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