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Quantitative imaging for targeted radionuclide therapy dosimetry : technical review

(2017) THERANOSTICS. 7(18). p.4551-4565
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Abstract
Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification. This article reviews the basic principles of TRT and discusses the latest development in radionuclide imaging techniques for different theranostic agents, with emphasis on their potential to improve personalized TRT dosimetry.
Keywords
Nuclear medicine imaging, targeted radionuclide therapy, internal dosimetry, theranostic agents, DIFFERENTIATED THYROID-CANCER, RADIOEMBOLIZATION Y-90 PET/CT, POSITRON-EMISSION-TOMOGRAPHY, PATIENT-SPECIFIC DOSIMETRY, ORGAN ACTIVITY ESTIMATION, NON-HODGKIN-LYMPHOMA, MONTE-CARLO, RADIATION-DOSIMETRY, NEUROENDOCRINE TUMORS, IMMUNO-PET

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Citation

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Chicago
Li, Tiantian, Edwin CI Ao, Bieke Lambert, Boudewijn Brans, Stefaan Vandenberghe, and Greta SP Mok. 2017. “Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry : Technical Review.” Theranostics 7 (18): 4551–4565.
APA
Li, Tiantian, Ao, E. C., Lambert, B., Brans, B., Vandenberghe, S., & Mok, G. S. (2017). Quantitative imaging for targeted radionuclide therapy dosimetry : technical review. THERANOSTICS, 7(18), 4551–4565.
Vancouver
1.
Li T, Ao EC, Lambert B, Brans B, Vandenberghe S, Mok GS. Quantitative imaging for targeted radionuclide therapy dosimetry : technical review. THERANOSTICS. 2017;7(18):4551–65.
MLA
Li, Tiantian, Edwin CI Ao, Bieke Lambert, et al. “Quantitative Imaging for Targeted Radionuclide Therapy Dosimetry : Technical Review.” THERANOSTICS 7.18 (2017): 4551–4565. Print.
@article{8537078,
  abstract     = {Targeted radionuclide therapy (TRT) is a promising technique for cancer therapy. However, in order to deliver the required dose to the tumor, minimize potential toxicity in normal organs, as well as monitor therapeutic effects, it is important to assess the individualized internal dosimetry based on patient-specific data. Advanced imaging techniques, especially radionuclide imaging, can be used to determine the spatial distribution of administered tracers for calculating the organ-absorbed dose. While planar scintigraphy is still the mainstream imaging method, SPECT, PET and bremsstrahlung imaging have promising properties to improve accuracy in quantification. This article reviews the basic principles of TRT and discusses the latest development in radionuclide imaging techniques for different theranostic agents, with emphasis on their potential to improve personalized TRT dosimetry.},
  author       = {Li, Tiantian and Ao, Edwin CI and Lambert, Bieke and Brans, Boudewijn and Vandenberghe, Stefaan and Mok, Greta SP},
  issn         = {1838-7640},
  journal      = {THERANOSTICS},
  language     = {eng},
  number       = {18},
  pages        = {4551--4565},
  title        = {Quantitative imaging for targeted radionuclide therapy dosimetry : technical review},
  url          = {http://dx.doi.org/10.7150/thno.19782},
  volume       = {7},
  year         = {2017},
}

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