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Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence

Marie-Astrid Denys UGent, Veerle Decalf UGent, Candy Kumps, Mirko Petrovic UGent, An-Sofie Goessaert UGent and Karel Everaert UGent (2017) INTERNATIONAL JOURNAL OF UROLOGY. 24(11). p.808-815
abstract
Objectives: To explore the mismatch between functional bladder capacity and nocturnal urine production, and to study the pathophysiology of an increased nocturnal urine production in older patients with urinary incontinence. Methods: The present prospective observational study included adults aged 65years with urinary incontinence. Participants completed questionnaires, frequency volume charts and renal function profiles. The nocturnal lower urinary tract symptom index was defined as nocturnal urine output/maximum voided volume; the nocturnal polyuria index as nocturnal/24h urine output. Results: The median age (n=95) was 74years (69-79), 87% were women and 73% had nocturnal lower urinary tract symptoms (nocturnal urinary incontinence or nocturia 2). Participants with nocturnal lower urinary tract symptoms had a significantly higher nocturnal urine output (809mL vs 650mL; P=0.001) and no significant difference in maximum voided volume (350mL vs 437mL; P=0.079) compared with participants without nocturnal lower urinary tract symptoms. Participants (nocturnal polyuria index >33% [n=56], nocturnal polyuria index >40% [n=42], nocturnal lower urinary tract symptom index >1.87 [n=51]) showed higher night-time diuresis rates, free water and sodium clearance compared with during the daytime. Controls (nocturnal polyuria index 33% [n=26], nocturnal polyuria index 40% [n=40], nocturnal lower urinary tract symptom index 1.87 [n=44]) had no circadian rhythm in their diuresis rate or sodium clearance, but more nocturnal free water clearance compared with during the daytime. Conclusions: The majority of older adults with urinary incontinence present nocturnal lower urinary tract symptoms. An increased nocturnal sodium diuresis seems to be the only mechanism differentiating patients with nocturnal lower urinary tract symptoms from controls.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
aging, lower urinary tract symptoms, nocturia, physiopathology, polyuria, NURSING-HOME, POLYURIA, MANAGEMENT, QUESTIONNAIRE, DESMOPRESSIN, DEFINITION, PEOPLE, COHORT, ADULTS, VOLUME
journal title
INTERNATIONAL JOURNAL OF UROLOGY
Int. J. Urol.
volume
24
issue
11
pages
808 - 815
Web of Science type
Article
Web of Science id
000414389400009
ISSN
0919-8172
DOI
10.1111/iju.13431
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8536403
handle
http://hdl.handle.net/1854/LU-8536403
date created
2017-11-07 12:04:13
date last changed
2018-03-20 08:45:05
@article{8536403,
  abstract     = {Objectives: To explore the mismatch between functional bladder capacity and nocturnal urine production, and to study the pathophysiology of an increased nocturnal urine production in older patients with urinary incontinence. 
Methods: The present prospective observational study included adults aged 65years with urinary incontinence. Participants completed questionnaires, frequency volume charts and renal function profiles. The nocturnal lower urinary tract symptom index was defined as nocturnal urine output/maximum voided volume; the nocturnal polyuria index as nocturnal/24h urine output. 
Results: The median age (n=95) was 74years (69-79), 87\% were women and 73\% had nocturnal lower urinary tract symptoms (nocturnal urinary incontinence or nocturia 2). Participants with nocturnal lower urinary tract symptoms had a significantly higher nocturnal urine output (809mL vs 650mL; P=0.001) and no significant difference in maximum voided volume (350mL vs 437mL; P=0.079) compared with participants without nocturnal lower urinary tract symptoms. Participants (nocturnal polyuria index {\textrangle}33\% [n=56], nocturnal polyuria index {\textrangle}40\% [n=42], nocturnal lower urinary tract symptom index {\textrangle}1.87 [n=51]) showed higher night-time diuresis rates, free water and sodium clearance compared with during the daytime. Controls (nocturnal polyuria index 33\% [n=26], nocturnal polyuria index 40\% [n=40], nocturnal lower urinary tract symptom index 1.87 [n=44]) had no circadian rhythm in their diuresis rate or sodium clearance, but more nocturnal free water clearance compared with during the daytime. 
Conclusions: The majority of older adults with urinary incontinence present nocturnal lower urinary tract symptoms. An increased nocturnal sodium diuresis seems to be the only mechanism differentiating patients with nocturnal lower urinary tract symptoms from controls.},
  author       = {Denys, Marie-Astrid and Decalf, Veerle and Kumps, Candy and Petrovic, Mirko and Goessaert, An-Sofie and Everaert, Karel},
  issn         = {0919-8172},
  journal      = {INTERNATIONAL JOURNAL OF UROLOGY},
  keyword      = {aging,lower urinary tract symptoms,nocturia,physiopathology,polyuria,NURSING-HOME,POLYURIA,MANAGEMENT,QUESTIONNAIRE,DESMOPRESSIN,DEFINITION,PEOPLE,COHORT,ADULTS,VOLUME},
  language     = {eng},
  number       = {11},
  pages        = {808--815},
  title        = {Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence},
  url          = {http://dx.doi.org/10.1111/iju.13431},
  volume       = {24},
  year         = {2017},
}

Chicago
Denys, Marie-Astrid, Veerle Decalf, Candy Kumps, Mirko Petrovic, An-Sofie Goessaert, and Karel Everaert. 2017. “Pathophysiology of Nocturnal Lower Urinary Tract Symptoms in Older Patients with Urinary Incontinence.” International Journal of Urology 24 (11): 808–815.
APA
Denys, M.-A., Decalf, V., Kumps, C., Petrovic, M., Goessaert, A.-S., & Everaert, K. (2017). Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence. INTERNATIONAL JOURNAL OF UROLOGY, 24(11), 808–815.
Vancouver
1.
Denys M-A, Decalf V, Kumps C, Petrovic M, Goessaert A-S, Everaert K. Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence. INTERNATIONAL JOURNAL OF UROLOGY. 2017;24(11):808–15.
MLA
Denys, Marie-Astrid, Veerle Decalf, Candy Kumps, et al. “Pathophysiology of Nocturnal Lower Urinary Tract Symptoms in Older Patients with Urinary Incontinence.” INTERNATIONAL JOURNAL OF UROLOGY 24.11 (2017): 808–815. Print.