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Exercise performance and quality of life in children with cystic fibrosis and mildly impaired lung function : relation with antibiotic treatments and hospitalization

(2017) EUROPEAN JOURNAL OF PEDIATRICS. 176(12). p.1689-1696
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Abstract
This study evaluates the impact of antibiotic treatments and hospitalization on exercise performance and health-related quality of life (QOL) in children with mild cystic fibrosis (CF) lung disease. Forty-seven children between 7 and 17 years with mild CF underwent a maximal exercise test including spiro-ergometry and filled out a QOL-questionnaire (PedsQL (TM)). Amount of antibiotic treatments (AB) and hospitalization days in the last 3 years were reviewed. FEV1% was mildly decreased (91.7 +/- 17.9 L/min, p = 0.02). Maximal oxygen consumption (VO(2)max), test duration and anaerobic threshold were lower compared to a control population (VO(2)max% 94 +/- 15 vs 103 +/- 13, p = 0.009). FEV1% correlated with AB and hospitalization episodes in the last year and 3 years before testing, VO(2)max% only correlated with AB in the last 3 years. Domains of school functioning and emotional functioning were low. Children with higher VO(2)max% and less AB in the last 3 years had better physical health. Physical health and school functioning were negatively correlated with hospitalization days in the last year. Conclusion: Patients with mild CF lung disease have good exercise performance although still lower than the normal population. VO2max% is affected by number of antibiotic treatments over a longer period. There is an impact of hospitalization days on quality of life.
Keywords
Cystic fibrosis, Children, Exercise performance, Exercise testing, Respiratory exacerbations, PULMONARY EXACERBATIONS, PHYSICAL-ACTIVITY, PROGNOSTIC VALUE, ADOLESCENTS, ADULTS, SURVIVAL, FEV1

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Chicago
Vandekerckhove, Kristof, Michiel Keyzer, Jasper Cornette, Ilse Coomans, Filip Pyl, Frans De Baets, Petra Schelstraete, et al. 2017. “Exercise Performance and Quality of Life in Children with Cystic Fibrosis and Mildly Impaired Lung Function : Relation with Antibiotic Treatments and Hospitalization.” European Journal of Pediatrics 176 (12): 1689–1696.
APA
Vandekerckhove, K., Keyzer, M., Cornette, J., Coomans, I., Pyl, F., De Baets, F., Schelstraete, P., et al. (2017). Exercise performance and quality of life in children with cystic fibrosis and mildly impaired lung function : relation with antibiotic treatments and hospitalization. EUROPEAN JOURNAL OF PEDIATRICS, 176(12), 1689–1696.
Vancouver
1.
Vandekerckhove K, Keyzer M, Cornette J, Coomans I, Pyl F, De Baets F, et al. Exercise performance and quality of life in children with cystic fibrosis and mildly impaired lung function : relation with antibiotic treatments and hospitalization. EUROPEAN JOURNAL OF PEDIATRICS. 2017;176(12):1689–96.
MLA
Vandekerckhove, Kristof et al. “Exercise Performance and Quality of Life in Children with Cystic Fibrosis and Mildly Impaired Lung Function : Relation with Antibiotic Treatments and Hospitalization.” EUROPEAN JOURNAL OF PEDIATRICS 176.12 (2017): 1689–1696. Print.
@article{8535786,
  abstract     = {This study evaluates the impact of antibiotic treatments and hospitalization on exercise performance and health-related quality of life (QOL) in children with mild cystic fibrosis (CF) lung disease. Forty-seven children between 7 and 17 years with mild CF underwent a maximal exercise test including spiro-ergometry and filled out a QOL-questionnaire (PedsQL (TM)). Amount of antibiotic treatments (AB) and hospitalization days in the last 3 years were reviewed. FEV1\% was mildly decreased (91.7 +/- 17.9 L/min, p = 0.02). Maximal oxygen consumption (VO(2)max), test duration and anaerobic threshold were lower compared to a control population (VO(2)max\% 94 +/- 15 vs 103 +/- 13, p = 0.009). FEV1\% correlated with AB and hospitalization episodes in the last year and 3 years before testing, VO(2)max\% only correlated with AB in the last 3 years. Domains of school functioning and emotional functioning were low. Children with higher VO(2)max\% and less AB in the last 3 years had better physical health. Physical health and school functioning were negatively correlated with hospitalization days in the last year. 
Conclusion: Patients with mild CF lung disease have good exercise performance although still lower than the normal population. VO2max\% is affected by number of antibiotic treatments over a longer period. There is an impact of hospitalization days on quality of life.},
  author       = {Vandekerckhove, Kristof and Keyzer, Michiel and Cornette, Jasper and Coomans, Ilse and Pyl, Filip and De Baets, Frans and Schelstraete, Petra and Haerynck, Filomeen and De Wolf, Dani{\"e}l and Van daele, Sabine and Boone, Jan},
  issn         = {0340-6199},
  journal      = {EUROPEAN JOURNAL OF PEDIATRICS},
  language     = {eng},
  number       = {12},
  pages        = {1689--1696},
  title        = {Exercise performance and quality of life in children with cystic fibrosis and mildly impaired lung function : relation with antibiotic treatments and hospitalization},
  url          = {http://dx.doi.org/10.1007/s00431-017-3024-7},
  volume       = {176},
  year         = {2017},
}

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