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How preparation changes the need for top-down control of the basal Ganglia when inhibiting premature actions

(2012) JOURNAL OF NEUROSCIENCE. 32(32). p.10870-10878
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Abstract
Goal-oriented signals from the prefrontal cortex gate the selection of appropriate actions in the basal ganglia. Key nodes within this fronto-basal ganglia action regulation network are increasingly engaged when one anticipates the need to inhibit and override planned actions. Here, we ask how the advance preparation of action plans modulates the need for fronto-subcortical control when a planned action needs to be withdrawn. Functional magnetic resonance imaging data were collected while human participants performed a stop task with cues indicating the likelihood of a stop signal being sounded. Mathematical modeling of go trial responses suggested that participants attained a more cautious response strategy when the probability of a stop signal increased. Effective connectivity analysis indicated that, even in the absence of stop signals, the proactive engagement of the full control network is tailored to the likelihood of stop trial occurrence. Importantly, during actual stop trials, the strength of fronto-subcortical projections was stronger when stopping had to be engaged reactively compared with when it was proactively prepared in advance. These findings suggest that fronto-basal ganglia control is strongest in an unpredictable environment, where the prefrontal cortex plays an important role in the optimization of reactive control. Importantly, these results further indicate that the advance preparation of action plans reduces the need for reactive fronto-basal ganglia communication to gate voluntary actions.
Keywords
INFERIOR FRONTAL-CORTEX, RESPONSE-INHIBITION, PARKINSONS-DISEASE, STOP-SIGNAL, COGNITIVE CONTROL, DECISION-MAKING, NEURAL BASIS, MOTOR, AREA, STIMULATION, MODELS

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Citation

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Chicago
Jahfari, Sara, Frederick Verbruggen, Michael J. Frank, Lourens J. Waldorp, Lorenza Colzato, K. Richard Ridderinkhof, and Birte U. Forstmann. 2012. “How Preparation Changes the Need for Top-down Control of the Basal Ganglia When Inhibiting Premature Actions.” Journal of Neuroscience 32 (32): 10870–10878.
APA
Jahfari, S., Verbruggen, F., Frank, M. J., Waldorp, L. J., Colzato, L., Ridderinkhof, K. R., & Forstmann, B. U. (2012). How preparation changes the need for top-down control of the basal Ganglia when inhibiting premature actions. JOURNAL OF NEUROSCIENCE, 32(32), 10870–10878.
Vancouver
1.
Jahfari S, Verbruggen F, Frank MJ, Waldorp LJ, Colzato L, Ridderinkhof KR, et al. How preparation changes the need for top-down control of the basal Ganglia when inhibiting premature actions. JOURNAL OF NEUROSCIENCE. Washington: Soc Neuroscience; 2012;32(32):10870–8.
MLA
Jahfari, Sara et al. “How Preparation Changes the Need for Top-down Control of the Basal Ganglia When Inhibiting Premature Actions.” JOURNAL OF NEUROSCIENCE 32.32 (2012): 10870–10878. Print.
@article{8534971,
  abstract     = {Goal-oriented signals from the prefrontal cortex gate the selection of appropriate actions in the basal ganglia. Key nodes within this fronto-basal ganglia action regulation network are increasingly engaged when one anticipates the need to inhibit and override planned actions. Here, we ask how the advance preparation of action plans modulates the need for fronto-subcortical control when a planned action needs to be withdrawn. Functional magnetic resonance imaging data were collected while human participants performed a stop task with cues indicating the likelihood of a stop signal being sounded. Mathematical modeling of go trial responses suggested that participants attained a more cautious response strategy when the probability of a stop signal increased. Effective connectivity analysis indicated that, even in the absence of stop signals, the proactive engagement of the full control network is tailored to the likelihood of stop trial occurrence. Importantly, during actual stop trials, the strength of fronto-subcortical projections was stronger when stopping had to be engaged reactively compared with when it was proactively prepared in advance. These findings suggest that fronto-basal ganglia control is strongest in an unpredictable environment, where the prefrontal cortex plays an important role in the optimization of reactive control. Importantly, these results further indicate that the advance preparation of action plans reduces the need for reactive fronto-basal ganglia communication to gate voluntary actions.},
  author       = {Jahfari, Sara and Verbruggen, Frederick and Frank, Michael J. and Waldorp, Lourens J. and Colzato, Lorenza and Ridderinkhof, K. Richard and Forstmann, Birte U.},
  issn         = {0270-6474},
  journal      = {JOURNAL OF NEUROSCIENCE},
  keywords     = {INFERIOR FRONTAL-CORTEX,RESPONSE-INHIBITION,PARKINSONS-DISEASE,STOP-SIGNAL,COGNITIVE CONTROL,DECISION-MAKING,NEURAL BASIS,MOTOR,AREA,STIMULATION,MODELS},
  language     = {eng},
  number       = {32},
  pages        = {10870--10878},
  publisher    = {Soc Neuroscience},
  title        = {How preparation changes the need for top-down control of the basal Ganglia when inhibiting premature actions},
  url          = {http://dx.doi.org/10.1523/JNEUROSCI.0902-12.2012},
  volume       = {32},
  year         = {2012},
}

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