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Response suppression by automatic retrieval of stimulus-stop association : evidence from transcranial magnetic stimulation

(2012) JOURNAL OF COGNITIVE NEUROSCIENCE. 24(9). p.1908-1918
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Abstract
Behavioral studies show that subjects respond more slowly to stimuli to which they previously stopped. This response slowing could be explained by "automatic inhibition" (i.e., the reinstantiation of motor suppression when a stimulus retrieves a stop association). Here we tested this using TMS. In Experiment 1, participants were trained to go or no-go to stimuli. Then, in a test phase, we compared the corticospinal excitability for go stimuli that were previously associated with stopping (no-go_then_go) with go stimuli that were previously associated with going (go_then_go). Corticospinal excitability was reduced for no-go_then_go compared with go_then_go stimuli at a mere 100 msec poststimulus. Although these results fit with automatic inhibition, there was, surprisingly, no suppression for no-go_then_no-go stimuli, although this should occur. We speculated that automatic inhibition lies within a continuum between effortful top-down response inhibition and no inhibition at all. When the need for executive control and active response suppression disappears, so does the manifestation of automatic inhibition. Therefore, it should emerge during go/no-go learning and disappear as performance asymptotes. Consistent with this idea, in Experiment 2, we demonstrated reduced corticospinal excitability for no-go versus go trials most prominently in the midphase of training but it wears off as performance asymptotes. We thus provide neurophysiological evidence for an inhibition mechanism that is automatically reinstantiated when a stimulus retrieves a learned stopping episode, but only in an executive context in which active suppression is required. This demonstrates that automatic and top-down inhibition jointly contribute to goal-directed behavior.
Keywords
INFERIOR FRONTAL GYRUS, COGNITIVE CONTROL, SIGNAL TASK, GO/NO-GO, INHIBITION, BRAIN, ACTIVATION, PARADIGMS, NETWORK, ALCOHOL

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Citation

Please use this url to cite or link to this publication:

Chicago
Chiu, Yu-Chin, Adam R. Aron, and Frederick Verbruggen. 2012. “Response Suppression by Automatic Retrieval of Stimulus-stop Association : Evidence from Transcranial Magnetic Stimulation.” Journal of Cognitive Neuroscience 24 (9): 1908–1918.
APA
Chiu, Y.-C., Aron, A. R., & Verbruggen, F. (2012). Response suppression by automatic retrieval of stimulus-stop association : evidence from transcranial magnetic stimulation. JOURNAL OF COGNITIVE NEUROSCIENCE, 24(9), 1908–1918.
Vancouver
1.
Chiu Y-C, Aron AR, Verbruggen F. Response suppression by automatic retrieval of stimulus-stop association : evidence from transcranial magnetic stimulation. JOURNAL OF COGNITIVE NEUROSCIENCE. Cambridge: Mit Press; 2012;24(9):1908–18.
MLA
Chiu, Yu-Chin, Adam R. Aron, and Frederick Verbruggen. “Response Suppression by Automatic Retrieval of Stimulus-stop Association : Evidence from Transcranial Magnetic Stimulation.” JOURNAL OF COGNITIVE NEUROSCIENCE 24.9 (2012): 1908–1918. Print.
@article{8534969,
  abstract     = {Behavioral studies show that subjects respond more slowly to stimuli to which they previously stopped. This response slowing could be explained by "automatic inhibition" (i.e., the reinstantiation of motor suppression when a stimulus retrieves a stop association). Here we tested this using TMS. In Experiment 1, participants were trained to go or no-go to stimuli. Then, in a test phase, we compared the corticospinal excitability for go stimuli that were previously associated with stopping (no-go_then_go) with go stimuli that were previously associated with going (go_then_go). Corticospinal excitability was reduced for no-go_then_go compared with go_then_go stimuli at a mere 100 msec poststimulus. Although these results fit with automatic inhibition, there was, surprisingly, no suppression for no-go_then_no-go stimuli, although this should occur. We speculated that automatic inhibition lies within a continuum between effortful top-down response inhibition and no inhibition at all. When the need for executive control and active response suppression disappears, so does the manifestation of automatic inhibition. Therefore, it should emerge during go/no-go learning and disappear as performance asymptotes. Consistent with this idea, in Experiment 2, we demonstrated reduced corticospinal excitability for no-go versus go trials most prominently in the midphase of training but it wears off as performance asymptotes. We thus provide neurophysiological evidence for an inhibition mechanism that is automatically reinstantiated when a stimulus retrieves a learned stopping episode, but only in an executive context in which active suppression is required. This demonstrates that automatic and top-down inhibition jointly contribute to goal-directed behavior.},
  author       = {Chiu, Yu-Chin and Aron, Adam R. and Verbruggen, Frederick},
  issn         = {0898-929X},
  journal      = {JOURNAL OF COGNITIVE NEUROSCIENCE},
  keywords     = {INFERIOR FRONTAL GYRUS,COGNITIVE CONTROL,SIGNAL TASK,GO/NO-GO,INHIBITION,BRAIN,ACTIVATION,PARADIGMS,NETWORK,ALCOHOL},
  language     = {eng},
  number       = {9},
  pages        = {1908--1918},
  publisher    = {Mit Press},
  title        = {Response suppression by automatic retrieval of stimulus-stop association : evidence from transcranial magnetic stimulation},
  volume       = {24},
  year         = {2012},
}

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