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Separating intentional inhibition of prepotent responses and resistance to proactive interference in alcohol-dependent individuals

(2013) DRUG AND ALCOHOL DEPENDENCE. 128(3). p.200-205
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Abstract
Background: Impulsivity is a hallmark of addictive behaviors. Addicts' weakened inhibition of irrelevant prepotent responses is commonly thought to explain this association. However, inhibition is not a unitary mechanism. This study investigated the efficiency of overcoming competition due to irrelevant responses (i.e., inhibition of a prepotent response) and overcoming competition in memory (i.e., resistance to proactive interference) in sober and recently detoxified alcohol-dependent individuals. Methods: Three cognitive tasks assessing the inhibition of a prepotent response (Hayling task, anti-saccade task and Stroop task) and two tasks tapping into the capacity to resist proactive interference (cued recall, Brown-Peterson variant) were administered to 30 non-amnesic recently detoxified alcohol-dependent individuals and 30 matched healthy participants without alcohol dependency. In addition, possible confounds such as verbal updating in working memory was assessed. Results: Alcohol-dependent subjects performed worse than healthy participants on the three cognitive tasks assessing the inhibition of irrelevant prepotent responses but group performance was similar in the tasks assessing overcoming proactive interference in memory, updating of working memory and abstract reasoning. Conclusions: These findings suggest that alcohol-dependence is mainly associated with impaired capacity to intentionally suppress irrelevant prepotent response information. Control of proactive interference from memory is preserved. Theoretical and clinical implications are discussed. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
Keywords
WORKING-MEMORY, DRUG-USE, EXECUTIVE FUNCTION, DIVIDED ATTENTION, TOURETTE-SYNDROME, IMPULSIVITY, PERFORMANCE, BEHAVIOR, DYSFUNCTION, DISORDERS, Alcoholism, Impulsivity, Inhibitions

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Chicago
Noel, Xavier, Martial van der Linden, Damien Brevers, Salvatore Campanella, Paul Verbanck, Catherine Hanak, Charles Kornreich, and Frederick Verbruggen. 2013. “Separating Intentional Inhibition of Prepotent Responses and Resistance to Proactive Interference in Alcohol-dependent Individuals.” Drug and Alcohol Dependence 128 (3): 200–205.
APA
Noel, X., van der Linden, M., Brevers, D., Campanella, S., Verbanck, P., Hanak, C., Kornreich, C., et al. (2013). Separating intentional inhibition of prepotent responses and resistance to proactive interference in alcohol-dependent individuals. DRUG AND ALCOHOL DEPENDENCE, 128(3), 200–205.
Vancouver
1.
Noel X, van der Linden M, Brevers D, Campanella S, Verbanck P, Hanak C, et al. Separating intentional inhibition of prepotent responses and resistance to proactive interference in alcohol-dependent individuals. DRUG AND ALCOHOL DEPENDENCE. Clare: Elsevier Ireland Ltd; 2013;128(3):200–5.
MLA
Noel, Xavier, Martial van der Linden, Damien Brevers, et al. “Separating Intentional Inhibition of Prepotent Responses and Resistance to Proactive Interference in Alcohol-dependent Individuals.” DRUG AND ALCOHOL DEPENDENCE 128.3 (2013): 200–205. Print.
@article{8534959,
  abstract     = {Background: Impulsivity is a hallmark of addictive behaviors. Addicts' weakened inhibition of irrelevant prepotent responses is commonly thought to explain this association. However, inhibition is not a unitary mechanism. This study investigated the efficiency of overcoming competition due to irrelevant responses (i.e., inhibition of a prepotent response) and overcoming competition in memory (i.e., resistance to proactive interference) in sober and recently detoxified alcohol-dependent individuals. Methods: Three cognitive tasks assessing the inhibition of a prepotent response (Hayling task, anti-saccade task and Stroop task) and two tasks tapping into the capacity to resist proactive interference (cued recall, Brown-Peterson variant) were administered to 30 non-amnesic recently detoxified alcohol-dependent individuals and 30 matched healthy participants without alcohol dependency. In addition, possible confounds such as verbal updating in working memory was assessed. Results: Alcohol-dependent subjects performed worse than healthy participants on the three cognitive tasks assessing the inhibition of irrelevant prepotent responses but group performance was similar in the tasks assessing overcoming proactive interference in memory, updating of working memory and abstract reasoning. Conclusions: These findings suggest that alcohol-dependence is mainly associated with impaired capacity to intentionally suppress irrelevant prepotent response information. Control of proactive interference from memory is preserved. Theoretical and clinical implications are discussed. (c) 2012 Elsevier Ireland Ltd. All rights reserved.},
  author       = {Noel, Xavier and van der Linden, Martial and Brevers, Damien and Campanella, Salvatore and Verbanck, Paul and Hanak, Catherine and Kornreich, Charles and Verbruggen, Frederick},
  issn         = {0376-8716},
  journal      = {DRUG AND ALCOHOL DEPENDENCE},
  language     = {eng},
  number       = {3},
  pages        = {200--205},
  publisher    = {Elsevier Ireland Ltd},
  title        = {Separating intentional inhibition of prepotent responses and resistance to proactive interference in alcohol-dependent individuals},
  url          = {http://dx.doi.org/10.1016/j.drugalcdep.2012.08.021},
  volume       = {128},
  year         = {2013},
}

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