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Carboxylate isosteres for caspase inhibitors : the acylsulfonamide case revisited

(2017) ORGANIC & BIOMOLECULAR CHEMISTRY. 15(35). p.7456-7473
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Abstract
As part of an ongoing effort to discover inhibitors of caspase-1 with an optimized selectivity and bio-pharmaceutical profile, acylsulfonamides were explored as carboxylate isosteres for caspase inhibitors. Acylsulfonamide analogues of the clinically investigated caspase-1 inhibitor VRT-043198 and of the pan-caspase inhibitor Z-VAD-CHO were synthesized. The isostere-containing analogues with an aldehyde warhead had inhibitory potencies comparable to the carboxylate references. In addition, the conformational and tautomeric characteristics of these molecules were determined using H-1-and C-13-based NMR. The propensity of acylsulfonamides with an aldehyde warhead to occur in a ring-closed conformation at physiological pH significantly increases the sensitivity to hydrolysis of the acylsulfonamide moiety, yielding the parent carboxylate containing inhibitors. These results indicate that the acylsulfonamide analogues of the aldehyde-based inhibitor VRT-043198 might have potential as a novel type of prodrug for the latter. Finally, inhibition of caspase 1 and 11 mediated inflammation in mouse macrophages was found to correlate with the potencies of the compounds in enzymatic assays.
Keywords
INTERLEUKIN-1-BETA CONVERTING-ENZYME, UNNATURAL AMINO-ACIDS, CONVENIENT, SYNTHESIS, SELECTIVE DETECTION, SULFONAMIDE GROUP, PRODRUG FORMS, DRUG, DESIGN, POTENT, DISCOVERY, ICE

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Chicago
Adriaenssens, Y, Daniel Jiménez Fernandez, Lieselotte Vande Walle, F Elvas, J Joossens, A Lambeir, K Augustyns, Mohamed Lamkanfi, and P Van der Veken. 2017. “Carboxylate Isosteres for Caspase Inhibitors : the Acylsulfonamide Case Revisited.” Organic & Biomolecular Chemistry 15 (35): 7456–7473.
APA
Adriaenssens, Y., Jiménez Fernandez, D., Vande Walle, L., Elvas, F., Joossens, J., Lambeir, A., Augustyns, K., et al. (2017). Carboxylate isosteres for caspase inhibitors : the acylsulfonamide case revisited. ORGANIC & BIOMOLECULAR CHEMISTRY, 15(35), 7456–7473.
Vancouver
1.
Adriaenssens Y, Jiménez Fernandez D, Vande Walle L, Elvas F, Joossens J, Lambeir A, et al. Carboxylate isosteres for caspase inhibitors : the acylsulfonamide case revisited. ORGANIC & BIOMOLECULAR CHEMISTRY. 2017;15(35):7456–73.
MLA
Adriaenssens, Y, Daniel Jiménez Fernandez, Lieselotte Vande Walle, et al. “Carboxylate Isosteres for Caspase Inhibitors : the Acylsulfonamide Case Revisited.” ORGANIC & BIOMOLECULAR CHEMISTRY 15.35 (2017): 7456–7473. Print.
@article{8534182,
  abstract     = {As part of an ongoing effort to discover inhibitors of caspase-1 with an optimized selectivity and bio-pharmaceutical profile, acylsulfonamides were explored as carboxylate isosteres for caspase inhibitors. Acylsulfonamide analogues of the clinically investigated caspase-1 inhibitor VRT-043198 and of the pan-caspase inhibitor Z-VAD-CHO were synthesized. The isostere-containing analogues with an aldehyde warhead had inhibitory potencies comparable to the carboxylate references. In addition, the conformational and tautomeric characteristics of these molecules were determined using H-1-and C-13-based NMR. The propensity of acylsulfonamides with an aldehyde warhead to occur in a ring-closed conformation at physiological pH significantly increases the sensitivity to hydrolysis of the acylsulfonamide moiety, yielding the parent carboxylate containing inhibitors. These results indicate that the acylsulfonamide analogues of the aldehyde-based inhibitor VRT-043198 might have potential as a novel type of prodrug for the latter. Finally, inhibition of caspase 1 and 11 mediated inflammation in mouse macrophages was found to correlate with the potencies of the compounds in enzymatic assays.},
  author       = {Adriaenssens, Y and Jim{\'e}nez Fernandez, Daniel and Vande Walle, Lieselotte and Elvas, F and Joossens, J and Lambeir, A and Augustyns, K and Lamkanfi, Mohamed and Van der Veken, P},
  issn         = {1477-0520},
  journal      = {ORGANIC \& BIOMOLECULAR CHEMISTRY},
  keyword      = {INTERLEUKIN-1-BETA CONVERTING-ENZYME,UNNATURAL AMINO-ACIDS,CONVENIENT,SYNTHESIS,SELECTIVE DETECTION,SULFONAMIDE GROUP,PRODRUG FORMS,DRUG,DESIGN,POTENT,DISCOVERY,ICE},
  language     = {eng},
  number       = {35},
  pages        = {7456--7473},
  title        = {Carboxylate isosteres for caspase inhibitors : the acylsulfonamide case revisited},
  url          = {http://dx.doi.org/10.1039/c7ob01403a},
  volume       = {15},
  year         = {2017},
}

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