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Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De Koker, Lien Van Hoecke UGent, Ans De Beuckelaer, Kenny Roose UGent, Kim Deswarte UGent, Monique Willart, Pieter Bogaert UGent, Thomas Naessens, Bruno De Geest UGent, Xavier Saelens UGent, et al. (2017) SCIENTIFIC REPORTS. 7.
abstract
Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented at the level of the individual cell, little is however known on the precise identity of the innate immune cells that govern T cell priming and polarisation to CpG adjuvanted protein antigens in vivo. In this study, we demonstrate that optimal induction of Th1 oriented immunity to CpG adjuvanted protein vaccines requires the coordinated actions of conventional DCs and of monocytes. Whilst conventional DCs were required for antigen presentation and initial T cell priming, monocytes constitute the main source of the Th1 polarising cytokine IL-12.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
DENDRITIC CELL-DEVELOPMENT, DUST MITE ALLERGEN, MEMORY CD8(+) T, LYMPH-NODES, ADAPTIVE IMMUNITY, BONE-MARROW, MEDIATED-IMMUNITY, EFFECTOR-CELLS, IN-VIVO, INFECTION
journal title
SCIENTIFIC REPORTS
Sci. Rep.
volume
7
article number
5986
pages
14 pages
Web of Science type
Article
Web of Science id
000405907800040
ISSN
2045-2322
DOI
10.1038/s41598-017-06236-6
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
8533756
handle
http://hdl.handle.net/1854/LU-8533756
date created
2017-10-10 14:45:43
date last changed
2017-10-27 07:15:01
@article{8533756,
  abstract     = {Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented at the level of the individual cell, little is however known on the precise identity of the innate immune cells that govern T cell priming and polarisation to CpG adjuvanted protein antigens in vivo. In this study, we demonstrate that optimal induction of Th1 oriented immunity to CpG adjuvanted protein vaccines requires the coordinated actions of conventional DCs and of monocytes. Whilst conventional DCs were required for antigen presentation and initial T cell priming, monocytes constitute the main source of the Th1 polarising cytokine IL-12.},
  articleno    = {5986},
  author       = {De Koker, Stefaan and Van Hoecke, Lien and De Beuckelaer, Ans and Roose, Kenny and Deswarte, Kim and Willart, Monique and Bogaert, Pieter and Naessens, Thomas and De Geest, Bruno and Saelens, Xavier and Lambrecht, Bart and Grooten, Johan},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {DENDRITIC CELL-DEVELOPMENT,DUST MITE ALLERGEN,MEMORY CD8(+) T,LYMPH-NODES,ADAPTIVE IMMUNITY,BONE-MARROW,MEDIATED-IMMUNITY,EFFECTOR-CELLS,IN-VIVO,INFECTION},
  language     = {eng},
  pages        = {14},
  title        = {Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12},
  url          = {http://dx.doi.org/10.1038/s41598-017-06236-6},
  volume       = {7},
  year         = {2017},
}

Chicago
De Koker, Stefaan, Lien Van Hoecke, Ans De Beuckelaer, Kenny Roose, Kim Deswarte, Monique Willart, Pieter Bogaert, et al. 2017. “Inflammatory Monocytes Regulate Th1 Oriented Immunity to CpG Adjuvanted Protein Vaccines Through Production of IL-12.” Scientific Reports 7.
APA
De Koker, S., Van Hoecke, L., De Beuckelaer, A., Roose, K., Deswarte, K., Willart, M., Bogaert, P., et al. (2017). Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12. SCIENTIFIC REPORTS, 7.
Vancouver
1.
De Koker S, Van Hoecke L, De Beuckelaer A, Roose K, Deswarte K, Willart M, et al. Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12. SCIENTIFIC REPORTS. 2017;7.
MLA
De Koker, Stefaan, Lien Van Hoecke, Ans De Beuckelaer, et al. “Inflammatory Monocytes Regulate Th1 Oriented Immunity to CpG Adjuvanted Protein Vaccines Through Production of IL-12.” SCIENTIFIC REPORTS 7 (2017): n. pag. Print.