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Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Stefaan De Koker (UGent) , Lien Van Hoecke (UGent) , Ans De Beuckelaer (UGent) , Kenny Roose (UGent) , Kim Deswarte (UGent) , Monique Willart (UGent) , Pieter Bogaert (UGent) , Thomas Naessens (UGent) , Bruno De Geest (UGent) , Xavier Saelens (UGent) , et al.
(2017) SCIENTIFIC REPORTS. 7.
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Abstract
Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented at the level of the individual cell, little is however known on the precise identity of the innate immune cells that govern T cell priming and polarisation to CpG adjuvanted protein antigens in vivo. In this study, we demonstrate that optimal induction of Th1 oriented immunity to CpG adjuvanted protein vaccines requires the coordinated actions of conventional DCs and of monocytes. Whilst conventional DCs were required for antigen presentation and initial T cell priming, monocytes constitute the main source of the Th1 polarising cytokine IL-12.
Keywords
DENDRITIC CELL-DEVELOPMENT, DUST MITE ALLERGEN, MEMORY CD8(+) T, LYMPH-NODES, ADAPTIVE IMMUNITY, BONE-MARROW, MEDIATED-IMMUNITY, EFFECTOR-CELLS, IN-VIVO, INFECTION

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MLA
De Koker, Stefaan, et al. “Inflammatory Monocytes Regulate Th1 Oriented Immunity to CpG Adjuvanted Protein Vaccines through Production of IL-12.” SCIENTIFIC REPORTS, vol. 7, 2017, doi:10.1038/s41598-017-06236-6.
APA
De Koker, S., Van Hoecke, L., De Beuckelaer, A., Roose, K., Deswarte, K., Willart, M., … Grooten, J. (2017). Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12. SCIENTIFIC REPORTS, 7. https://doi.org/10.1038/s41598-017-06236-6
Chicago author-date
De Koker, Stefaan, Lien Van Hoecke, Ans De Beuckelaer, Kenny Roose, Kim Deswarte, Monique Willart, Pieter Bogaert, et al. 2017. “Inflammatory Monocytes Regulate Th1 Oriented Immunity to CpG Adjuvanted Protein Vaccines through Production of IL-12.” SCIENTIFIC REPORTS 7. https://doi.org/10.1038/s41598-017-06236-6.
Chicago author-date (all authors)
De Koker, Stefaan, Lien Van Hoecke, Ans De Beuckelaer, Kenny Roose, Kim Deswarte, Monique Willart, Pieter Bogaert, Thomas Naessens, Bruno De Geest, Xavier Saelens, Bart Lambrecht, and Johan Grooten. 2017. “Inflammatory Monocytes Regulate Th1 Oriented Immunity to CpG Adjuvanted Protein Vaccines through Production of IL-12.” SCIENTIFIC REPORTS 7. doi:10.1038/s41598-017-06236-6.
Vancouver
1.
De Koker S, Van Hoecke L, De Beuckelaer A, Roose K, Deswarte K, Willart M, et al. Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12. SCIENTIFIC REPORTS. 2017;7.
IEEE
[1]
S. De Koker et al., “Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12,” SCIENTIFIC REPORTS, vol. 7, 2017.
@article{8533756,
  abstract     = {{Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively documented at the level of the individual cell, little is however known on the precise identity of the innate immune cells that govern T cell priming and polarisation to CpG adjuvanted protein antigens in vivo. In this study, we demonstrate that optimal induction of Th1 oriented immunity to CpG adjuvanted protein vaccines requires the coordinated actions of conventional DCs and of monocytes. Whilst conventional DCs were required for antigen presentation and initial T cell priming, monocytes constitute the main source of the Th1 polarising cytokine IL-12.}},
  articleno    = {{5986}},
  author       = {{De Koker, Stefaan and Van Hoecke, Lien and De Beuckelaer, Ans and Roose, Kenny and Deswarte, Kim and Willart, Monique and Bogaert, Pieter and Naessens, Thomas and De Geest, Bruno and Saelens, Xavier and Lambrecht, Bart and Grooten, Johan}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{DENDRITIC CELL-DEVELOPMENT,DUST MITE ALLERGEN,MEMORY CD8(+) T,LYMPH-NODES,ADAPTIVE IMMUNITY,BONE-MARROW,MEDIATED-IMMUNITY,EFFECTOR-CELLS,IN-VIVO,INFECTION}},
  language     = {{eng}},
  pages        = {{14}},
  title        = {{Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12}},
  url          = {{http://doi.org/10.1038/s41598-017-06236-6}},
  volume       = {{7}},
  year         = {{2017}},
}
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