Advanced search
1 file | 1.38 MB

Sole prednisolone therapy in canine meningoencephalitis of unknown etiology

Ine Cornelis (UGent) , Luc Van Ham (UGent) , Steven De Decker, Kaatje Kromhout (UGent) , Klara Goethals (UGent) , Ingrid Gielen (UGent) and Sofie Bhatti (UGent)
Author
Organization
Abstract
Meningoencephalitis of unknown etiology (MUE) is a frequently diagnosed and often fatal disease in veterinary neurology. The aim of this retrospective study was to assess the efficacy of three different sole prednisolone treatment schedules in dogs diagnosed with MUE. The dogs were diagnosed clinically with MUE based on previously described inclusion criteria, and treated with a three-, eight- or eighteen-week-tapering prednisolone schedule. Thirty eight dogs were included in the study. Seventeen, fifteen and six dogs received the three-, eight- and eighteen-week tapering schedule, respectively. Overall, 37% of the dogs died or were euthanized because of MUE, and a significant difference in survival time was seen between the three treatment schedules. Surprisingly, the highest number of dogs that died because of MUE was seen in the eight week treatment schedule (56%), followed by the three-week (26%) and eighteen-week (0%) treatment schedule. Based on the results of this study, no definitive conclusions can be drawn regarding the ideal prednisolone dosing protocol for dogs diagnosed with MUE. However, a more aggressive and immunosuppressive treatment protocol might lead to a better outcome.
Keywords
GRANULOMATOUS MENINGOENCEPHALOMYELITIS, DOGS

Downloads

  • ArtinEnglish03.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.38 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Cornelis, Ine, Luc Van Ham, Steven De Decker, Kaatje Kromhout, Klara Goethals, Ingrid Gielen, and Sofie Bhatti. 2017. “Sole Prednisolone Therapy in Canine Meningoencephalitis of Unknown Etiology.” Vlaams Diergeneeskundig Tijdschrift 86 (1): 24–28.
APA
Cornelis, Ine, Van Ham, L., De Decker, S., Kromhout, K., Goethals, K., Gielen, I., & Bhatti, S. (2017). Sole prednisolone therapy in canine meningoencephalitis of unknown etiology. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 86(1), 24–28.
Vancouver
1.
Cornelis I, Van Ham L, De Decker S, Kromhout K, Goethals K, Gielen I, et al. Sole prednisolone therapy in canine meningoencephalitis of unknown etiology. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2017;86(1):24–8.
MLA
Cornelis, Ine, Luc Van Ham, Steven De Decker, et al. “Sole Prednisolone Therapy in Canine Meningoencephalitis of Unknown Etiology.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 86.1 (2017): 24–28. Print.
@article{8533687,
  abstract     = {Meningoencephalitis of unknown etiology (MUE) is a frequently diagnosed and often fatal disease in veterinary neurology. The aim of this retrospective study was to assess the efficacy of three different sole prednisolone treatment schedules in dogs diagnosed with MUE. The dogs were diagnosed clinically with MUE based on previously described inclusion criteria, and treated with a three-, eight- or eighteen-week-tapering prednisolone schedule. Thirty eight dogs were included in the study. Seventeen, fifteen and six dogs received the three-, eight- and eighteen-week tapering schedule, respectively. Overall, 37\% of the dogs died or were euthanized because of MUE, and a significant difference in survival time was seen between the three treatment schedules. Surprisingly, the highest number of dogs that died because of MUE was seen in the eight week treatment schedule (56\%), followed by the three-week (26\%) and eighteen-week (0\%) treatment schedule. Based on the results of this study, no definitive conclusions can be drawn regarding the ideal prednisolone dosing protocol for dogs diagnosed with MUE. However, a more aggressive and immunosuppressive treatment protocol might lead to a better outcome.},
  author       = {Cornelis, Ine and Van Ham, Luc and De Decker, Steven and Kromhout, Kaatje and Goethals, Klara and Gielen, Ingrid and Bhatti, Sofie},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  keyword      = {GRANULOMATOUS MENINGOENCEPHALOMYELITIS,DOGS},
  language     = {eng},
  number       = {1},
  pages        = {24--28},
  title        = {Sole prednisolone therapy in canine meningoencephalitis of unknown etiology},
  volume       = {86},
  year         = {2017},
}

Web of Science
Times cited: