@article{8533293,
  abstract     = {{Hybrid seed lethality as a consequence of interspecies or interploidy hybridizations is a major mechanism of reproductive isolation in plants. This mechanism is manifested in the endosperm, a dosage-sensitive tissue supporting embryo growth. Deregulated expression of imprinted genes such as ADMETOS (ADM) underpin the interploidy hybridization barrier in Arabidopsis thaliana; however, the mechanisms of their action remained unknown. In this study, we show that ADM interacts with the AT hook domain protein AHL10 and the SET domain-containing SU (VAR) 3-9 homolog SUVH9 and ectopically recruits the heterochromatic mark H3K9me2 to AT-rich transposable elements (TEs), causing deregulated expression of neighboring genes. Several hybrid incompatibility genes identified in Drosophila encode for dosage-sensitive heterochromatin-interacting proteins, which has led to the suggestion that hybrid incompatibilities evolve as a consequence of interspecies divergence of selfish DNA elements and their regulation. Our data show that imbalance of dosage-sensitive chromatin regulators underpins the barrier to interploidy hybridization in Arabidopsis, suggesting that reproductive isolation as a consequence of epigenetic regulation of TEs is a conserved feature in animals and plants.}},
  author       = {{Jiang, Hua and Moreno-Romero, Jordi and Santos-Gonzalez, Juan and De Jaeger, Geert and Gevaert, Kris and Van De Slijke, Eveline and Kohler, Claudia}},
  issn         = {{0890-9369}},
  journal      = {{GENES & DEVELOPMENT}},
  keywords     = {{TANDEM AFFINITY PURIFICATION,DIRECTED DNA METHYLATION,RNA-POLYMERASE,V,FLOWERING PLANTS,GENE-EXPRESSION,DROSOPHILA-MELANOGASTER,HYBRIDIZATION BARRIER,SEED DEVELOPMENT,ENDOSPERM,HETEROCHROMATIN,hybrid incompatibility,heterochromatin,imprinted genes,endosperm,transposable elements,polyploidy}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1272--1287}},
  title        = {{Ectopic application of the repressive histone modification H3K9me2 establishes post-zygotic reproductive isolation in Arabidopsis thaliana}},
  url          = {{http://doi.org/10.1101/gad.299347.117}},
  volume       = {{31}},
  year         = {{2017}},
}

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