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Tissue-specific control of the endocycle by the anaphase promoting complex/cyclosome inhibitors UVI4 and DEL1

Jefri Heyman (UGent) , Stefanie Polyn (UGent) , Thomas Eekhout (UGent) and Lieven De Veylder (UGent)
(2017) PLANT PHYSIOLOGY. 175(1). p.303-313
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Abstract
The endocycle represents a modified mitotic cell cycle that in plants is often coupled to cell enlargement and differentiation. Endocycle onset is controlled by activity of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle factors for destruction. CELL CYCLE SWITCH52 (CCS52) proteins represent rate-limiting activator subunits of the APC/C. In Arabidopsis (Arabidopsis thaliana), mutations in either CCS52A1 or CCS52A2 activators result in a delayed endocycle onset, whereas their overexpression triggers increased DNA ploidy levels. Here, the relative contribution of the APC/C-CCS52A1 and APC/C-CCS52A2 complexes to different developmental processes was studied through analysis of their negative regulators, being the ULTRAVIOLET-B-INSENSITIVE4 protein and the DP-E2F-Like1 transcriptional repressor, respectively. Our data illustrate cooperative activity of the APC/C-CCS52A1 and APC/C-CCS52A2 complexes during root and trichome development, but functional interdependency during leaf development. Furthermore, we found APC/C-CCS52A1 activity to control CCS52A2 expression. We conclude that interdependency of CCS52A-controlled APC/C activity is controlled in a tissue-specific manner.
Keywords
CELL-CYCLE PROGRESSION, ARABIDOPSIS-THALIANA, DROSOPHILA ENDOCYCLE, ENDO-REDUPLICATION, APC/C ACTIVATOR, FRUIT-GROWTH, ORGAN GROWTH, ENDOREDUPLICATION, COMPLEX, ENDOREPLICATION

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MLA
Heyman, Jefri et al. “Tissue-specific Control of the Endocycle by the Anaphase Promoting Complex/cyclosome Inhibitors UVI4 and DEL1.” PLANT PHYSIOLOGY 175.1 (2017): 303–313. Print.
APA
Heyman, J., Polyn, S., Eekhout, T., & De Veylder, L. (2017). Tissue-specific control of the endocycle by the anaphase promoting complex/cyclosome inhibitors UVI4 and DEL1. PLANT PHYSIOLOGY, 175(1), 303–313.
Chicago author-date
Heyman, Jefri, Stefanie Polyn, Thomas Eekhout, and Lieven De Veylder. 2017. “Tissue-specific Control of the Endocycle by the Anaphase Promoting Complex/cyclosome Inhibitors UVI4 and DEL1.” Plant Physiology 175 (1): 303–313.
Chicago author-date (all authors)
Heyman, Jefri, Stefanie Polyn, Thomas Eekhout, and Lieven De Veylder. 2017. “Tissue-specific Control of the Endocycle by the Anaphase Promoting Complex/cyclosome Inhibitors UVI4 and DEL1.” Plant Physiology 175 (1): 303–313.
Vancouver
1.
Heyman J, Polyn S, Eekhout T, De Veylder L. Tissue-specific control of the endocycle by the anaphase promoting complex/cyclosome inhibitors UVI4 and DEL1. PLANT PHYSIOLOGY. 2017;175(1):303–13.
IEEE
[1]
J. Heyman, S. Polyn, T. Eekhout, and L. De Veylder, “Tissue-specific control of the endocycle by the anaphase promoting complex/cyclosome inhibitors UVI4 and DEL1,” PLANT PHYSIOLOGY, vol. 175, no. 1, pp. 303–313, 2017.
@article{8533287,
  abstract     = {The endocycle represents a modified mitotic cell cycle that in plants is often coupled to cell enlargement and differentiation. Endocycle onset is controlled by activity of the Anaphase Promoting Complex/Cyclosome (APC/C), a multisubunit E3 ubiquitin ligase targeting cell-cycle factors for destruction. CELL CYCLE SWITCH52 (CCS52) proteins represent rate-limiting activator subunits of the APC/C. In Arabidopsis (Arabidopsis thaliana), mutations in either CCS52A1 or CCS52A2 activators result in a delayed endocycle onset, whereas their overexpression triggers increased DNA ploidy levels. Here, the relative contribution of the APC/C-CCS52A1 and APC/C-CCS52A2 complexes to different developmental processes was studied through analysis of their negative regulators, being the ULTRAVIOLET-B-INSENSITIVE4 protein and the DP-E2F-Like1 transcriptional repressor, respectively. Our data illustrate cooperative activity of the APC/C-CCS52A1 and APC/C-CCS52A2 complexes during root and trichome development, but functional interdependency during leaf development. Furthermore, we found APC/C-CCS52A1 activity to control CCS52A2 expression. We conclude that interdependency of CCS52A-controlled APC/C activity is controlled in a tissue-specific manner.},
  author       = {Heyman, Jefri and Polyn, Stefanie and Eekhout, Thomas and De Veylder, Lieven},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keywords     = {CELL-CYCLE PROGRESSION,ARABIDOPSIS-THALIANA,DROSOPHILA ENDOCYCLE,ENDO-REDUPLICATION,APC/C ACTIVATOR,FRUIT-GROWTH,ORGAN GROWTH,ENDOREDUPLICATION,COMPLEX,ENDOREPLICATION},
  language     = {eng},
  number       = {1},
  pages        = {303--313},
  title        = {Tissue-specific control of the endocycle by the anaphase promoting complex/cyclosome inhibitors UVI4 and DEL1},
  url          = {http://dx.doi.org/10.1104/pp.17.00785},
  volume       = {175},
  year         = {2017},
}

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