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Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia

Marc Coppens UGent, S Anssens, Aliaksandra Parashchanka, Kristien Roelens UGent, Ellen Deschepper UGent, Stefan De Hert UGent and Patrick Wouters UGent (2017) ANAESTHESIA. 72(5). p.598-602
abstract
The primary goal of this study was to determine the median effective dose (ED50) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 mu g sufentanil in 7 ml saline. Effective analgesia was defined as a score <= 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50 of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95%CI) 12.0 (9.3-17.0) mg.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
EPIDURAL-ANESTHESIA, CESAREAN-SECTION, DOUBLE-BLIND, DOWN DESIGN, BUPIVACAINE, 2-CHLOROPROCAINE, LIDOCAINE, SUFENTANIL, TOXICITY, DELIVERY, chloroprocaine metabolism, combined spinal-epidural, labour analgesia, median effective dose
journal title
ANAESTHESIA
Anaesthesia
volume
72
issue
5
pages
598 - 602
Web of Science type
Article
Web of Science id
000399337100008
ISSN
0003-2409
1365-2044
DOI
10.1111/anae.13808
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8532552
handle
http://hdl.handle.net/1854/LU-8532552
date created
2017-09-28 09:44:48
date last changed
2017-11-13 13:12:57
@article{8532552,
  abstract     = {The primary goal of this study was to determine the median effective dose (ED50) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1\% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 mu g sufentanil in 7 ml saline. Effective analgesia was defined as a score {\textlangle}= 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50 of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95\%CI) 12.0 (9.3-17.0) mg.},
  author       = {Coppens, Marc and Anssens, S and Parashchanka, Aliaksandra and Roelens, Kristien and Deschepper, Ellen and De Hert, Stefan and Wouters, Patrick},
  issn         = {0003-2409},
  journal      = {ANAESTHESIA},
  keyword      = {EPIDURAL-ANESTHESIA,CESAREAN-SECTION,DOUBLE-BLIND,DOWN DESIGN,BUPIVACAINE,2-CHLOROPROCAINE,LIDOCAINE,SUFENTANIL,TOXICITY,DELIVERY,chloroprocaine metabolism,combined spinal-epidural,labour analgesia,median effective dose},
  language     = {eng},
  number       = {5},
  pages        = {598--602},
  title        = {Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia},
  url          = {http://dx.doi.org/10.1111/anae.13808},
  volume       = {72},
  year         = {2017},
}

Chicago
Coppens, Marc, S Anssens, ALIAKSANDRA PARASHCHANKA, Kristien Roelens, Ellen Deschepper, Stefan De Hert, and Patrick Wouters. 2017. “Determination of the Median Effective Dose (ED50) of Spinal Chloroprocaine in Labour Analgesia.” Anaesthesia 72 (5): 598–602.
APA
Coppens, Marc, Anssens, S., PARASHCHANKA, A., Roelens, K., Deschepper, E., De Hert, S., & Wouters, P. (2017). Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia. ANAESTHESIA, 72(5), 598–602.
Vancouver
1.
Coppens M, Anssens S, PARASHCHANKA A, Roelens K, Deschepper E, De Hert S, et al. Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia. ANAESTHESIA. 2017;72(5):598–602.
MLA
Coppens, Marc, S Anssens, ALIAKSANDRA PARASHCHANKA, et al. “Determination of the Median Effective Dose (ED50) of Spinal Chloroprocaine in Labour Analgesia.” ANAESTHESIA 72.5 (2017): 598–602. Print.