Advanced search
1 file | 82.02 KB

Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia

(2017) ANAESTHESIA. 72(5). p.598-602
Author
Organization
Abstract
The primary goal of this study was to determine the median effective dose (ED50) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 mu g sufentanil in 7 ml saline. Effective analgesia was defined as a score <= 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50 of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95%CI) 12.0 (9.3-17.0) mg.
Keywords
EPIDURAL-ANESTHESIA, CESAREAN-SECTION, DOUBLE-BLIND, DOWN DESIGN, BUPIVACAINE, 2-CHLOROPROCAINE, LIDOCAINE, SUFENTANIL, TOXICITY, DELIVERY, chloroprocaine metabolism, combined spinal-epidural, labour analgesia, median effective dose

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 82.02 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Coppens, Marc, S Anssens, Aliaksandra Parashchanka, Kristien Roelens, Ellen Deschepper, Stefan De Hert, and Patrick Wouters. 2017. “Determination of the Median Effective Dose (ED50) of Spinal Chloroprocaine in Labour Analgesia.” Anaesthesia 72 (5): 598–602.
APA
Coppens, Marc, Anssens, S., Parashchanka, A., Roelens, K., Deschepper, E., De Hert, S., & Wouters, P. (2017). Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia. ANAESTHESIA, 72(5), 598–602.
Vancouver
1.
Coppens M, Anssens S, Parashchanka A, Roelens K, Deschepper E, De Hert S, et al. Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia. ANAESTHESIA. 2017;72(5):598–602.
MLA
Coppens, Marc, S Anssens, Aliaksandra Parashchanka, et al. “Determination of the Median Effective Dose (ED50) of Spinal Chloroprocaine in Labour Analgesia.” ANAESTHESIA 72.5 (2017): 598–602. Print.
@article{8532552,
  abstract     = {The primary goal of this study was to determine the median effective dose (ED50) of spinal chloroprocaine for labour analgesia. Thirty-eight parturients requesting neuraxial analgesia were enrolled. Doses of 1\% chloroprocaine were determined by the technique of up-down sequential allocation, with an initial dose of 20 mg and steps of 2 mg. The chloroprocaine spinal dose was given as the spinal component of a combined spinal-epidural, which was then supplemented with an epidural dose of 7.5 mu g sufentanil in 7 ml saline. Effective analgesia was defined as a score {\textlangle}= 10 mm within 15 min on a 100-mm visual analogue pain scale. Using the isotonic regression estimator method, the ED50 of chloroprocaine for the spinal component of a combined spinal-epidural for labour was calculated to be median (95\%CI) 12.0 (9.3-17.0) mg.},
  author       = {Coppens, Marc and Anssens, S and Parashchanka, Aliaksandra and Roelens, Kristien and Deschepper, Ellen and De Hert, Stefan and Wouters, Patrick},
  issn         = {0003-2409},
  journal      = {ANAESTHESIA},
  keyword      = {EPIDURAL-ANESTHESIA,CESAREAN-SECTION,DOUBLE-BLIND,DOWN DESIGN,BUPIVACAINE,2-CHLOROPROCAINE,LIDOCAINE,SUFENTANIL,TOXICITY,DELIVERY,chloroprocaine metabolism,combined spinal-epidural,labour analgesia,median effective dose},
  language     = {eng},
  number       = {5},
  pages        = {598--602},
  title        = {Determination of the median effective dose (ED50) of spinal chloroprocaine in labour analgesia},
  url          = {http://dx.doi.org/10.1111/anae.13808},
  volume       = {72},
  year         = {2017},
}

Altmetric
View in Altmetric
Web of Science
Times cited: