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Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration

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Abstract
This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.
Keywords
RESPONSE-SURFACE MODEL, TARGET-CONTROLLED INFUSION, EFFECT-SITE, CONCENTRATION, INTRAOPERATIVE PLASMA-CONCENTRATIONS, AUDITORY-EVOKED, POTENTIALS, BISPECTRAL INDEX, GENERAL-ANESTHESIA, PROTEIN-BINDING, PROPOFOL CONCENTRATION, SKIN INCISION, anesthetics, drug interactions, pharmacology

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MLA
van den Berg, JP et al. “Pharmacokinetic and Pharmacodynamic Interactions in Anaesthesia : a Review of Current Knowledge and How It Can Be Used to Optimize Anaesthetic Drug Administration.” BRITISH JOURNAL OF ANAESTHESIA 118.1 (2017): 44–57. Print.
APA
van den Berg, J., Vereecke, H., Proost, J., Eleveld, D., Wietasch, J., Absalom, A., & Struys, M. (2017). Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration. BRITISH JOURNAL OF ANAESTHESIA, 118(1), 44–57.
Chicago author-date
van den Berg, JP, HEM Vereecke, JH Proost, DJ Eleveld, JKG Wietasch, AR Absalom, and Michel Struys. 2017. “Pharmacokinetic and Pharmacodynamic Interactions in Anaesthesia : a Review of Current Knowledge and How It Can Be Used to Optimize Anaesthetic Drug Administration.” British Journal of Anaesthesia 118 (1): 44–57.
Chicago author-date (all authors)
van den Berg, JP, HEM Vereecke, JH Proost, DJ Eleveld, JKG Wietasch, AR Absalom, and Michel Struys. 2017. “Pharmacokinetic and Pharmacodynamic Interactions in Anaesthesia : a Review of Current Knowledge and How It Can Be Used to Optimize Anaesthetic Drug Administration.” British Journal of Anaesthesia 118 (1): 44–57.
Vancouver
1.
van den Berg J, Vereecke H, Proost J, Eleveld D, Wietasch J, Absalom A, et al. Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration. BRITISH JOURNAL OF ANAESTHESIA. 2017;118(1):44–57.
IEEE
[1]
J. van den Berg et al., “Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration,” BRITISH JOURNAL OF ANAESTHESIA, vol. 118, no. 1, pp. 44–57, 2017.
@article{8532536,
  abstract     = {This review describes the basics of pharmacokinetic and pharmacodynamic drug interactions and methodological points of particular interest when designing drug interaction studies. It also provides an overview of the available literature concerning interactions, with emphasis on graphic representation of interactions using isoboles and response surface models. It gives examples on how to transform this knowledge into clinically and educationally applicable (bedside) tools.},
  author       = {van den Berg, JP and Vereecke, HEM and Proost, JH and Eleveld, DJ and Wietasch, JKG and Absalom, AR and Struys, Michel},
  issn         = {0007-0912},
  journal      = {BRITISH JOURNAL OF ANAESTHESIA},
  keywords     = {RESPONSE-SURFACE MODEL,TARGET-CONTROLLED INFUSION,EFFECT-SITE,CONCENTRATION,INTRAOPERATIVE PLASMA-CONCENTRATIONS,AUDITORY-EVOKED,POTENTIALS,BISPECTRAL INDEX,GENERAL-ANESTHESIA,PROTEIN-BINDING,PROPOFOL CONCENTRATION,SKIN INCISION,anesthetics,drug interactions,pharmacology},
  language     = {eng},
  number       = {1},
  pages        = {44--57},
  title        = {Pharmacokinetic and pharmacodynamic interactions in anaesthesia : a review of current knowledge and how it can be used to optimize anaesthetic drug administration},
  url          = {http://dx.doi.org/10.1093/bja/aew312},
  volume       = {118},
  year         = {2017},
}

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