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Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)

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Abstract
Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target cyclooxygenase-2 (COX-2), an enzyme mainly responsible for induction of inflammation, pyresis and pain. Although commonly used in avian medicine, limited pharmacokinetic (PK) data in domestic and companion birds are available. In this study, PK parameters and absolute oral bioavailability expressed as percentage (F%) of celecoxib (10 mg/kg BW), mavacoxib (4 mg/kg BW) and meloxicam (1 mg/kg BW) were determined following single oral (PO) and intravenous (IV) administration to cockatiels (Nymphicus hollandicus). The drugs were quantified in plasma by liquid chromatography-tandem mass spectrometry. Data were processed using the nonlinear mixed effects (NLME) approach. In contrast to celecoxib (T-1/2el = 0.88 h) and meloxicam (T-1/2el = 0.90 h), mavacoxib has a prolonged elimination half-life (T-1/2el = 135 h) following oral administration of a commercial formulation (CF). High to complete oral absorption was observed following oral administration of celecoxib (F% = 56-110%) and mavacoxib (F% = 111-113%), CF and standard solutions, respectively. In contrast, the F% of meloxicam was low (F% = 11%). Based on the presented results, a less frequent dosing of mavacoxib is proposed compared to celecoxib and meloxicam. However, pharmacodynamic and safety studies are necessary to further investigate the use of these NSAIDs in cockatiels.
Keywords
NONSTEROIDAL ANTIINFLAMMATORY DRUGS, PARROTS AMAZONA-VENTRALIS, DOGS, PHARMACODYNAMICS, BIRDS, PATTERN, HUMANS, PLASMA, COXIBS, FOOD

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Chicago
Dhondt, Laura, Mathias Devreese, Siska Croubels, Siegrid De Baere, Roel Haesendonck, Tess Goessens, Ronette Gehring, Patrick De Backer, and Gunther Antonissen. 2017. “Comparative Population Pharmacokinetics and Absolute Oral Bioavailability of COX-2 Selective Inhibitors Celecoxib, Mavacoxib and Meloxicam in Cockatiels (Nymphicus Hollandicus).” Scientific Reports 7.
APA
Dhondt, L., Devreese, M., Croubels, S., De Baere, S., Haesendonck, R., Goessens, T., Gehring, R., et al. (2017). Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). SCIENTIFIC REPORTS, 7.
Vancouver
1.
Dhondt L, Devreese M, Croubels S, De Baere S, Haesendonck R, Goessens T, et al. Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus). SCIENTIFIC REPORTS. 2017;7.
MLA
Dhondt, Laura, Mathias Devreese, Siska Croubels, et al. “Comparative Population Pharmacokinetics and Absolute Oral Bioavailability of COX-2 Selective Inhibitors Celecoxib, Mavacoxib and Meloxicam in Cockatiels (Nymphicus Hollandicus).” SCIENTIFIC REPORTS 7 (2017): n. pag. Print.
@article{8532194,
  abstract     = {Selective COX-2 inhibitors are non-steroidal anti-inflammatory drugs which directly target cyclooxygenase-2 (COX-2), an enzyme mainly responsible for induction of inflammation, pyresis and pain. Although commonly used in avian medicine, limited pharmacokinetic (PK) data in domestic and companion birds are available. In this study, PK parameters and absolute oral bioavailability expressed as percentage (F\%) of celecoxib (10 mg/kg BW), mavacoxib (4 mg/kg BW) and meloxicam (1 mg/kg BW) were determined following single oral (PO) and intravenous (IV) administration to cockatiels (Nymphicus hollandicus). The drugs were quantified in plasma by liquid chromatography-tandem mass spectrometry. Data were processed using the nonlinear mixed effects (NLME) approach. In contrast to celecoxib (T-1/2el = 0.88 h) and meloxicam (T-1/2el = 0.90 h), mavacoxib has a prolonged elimination half-life (T-1/2el = 135 h) following oral administration of a commercial formulation (CF). High to complete oral absorption was observed following oral administration of celecoxib (F\% = 56-110\%) and mavacoxib (F\% = 111-113\%), CF and standard solutions, respectively. In contrast, the F\% of meloxicam was low (F\% = 11\%). Based on the presented results, a less frequent dosing of mavacoxib is proposed compared to celecoxib and meloxicam. However, pharmacodynamic and safety studies are necessary to further investigate the use of these NSAIDs in cockatiels.},
  articleno    = {12043},
  author       = {Dhondt, Laura and Devreese, Mathias and Croubels, Siska and De Baere, Siegrid and Haesendonck, Roel and Goessens, Tess and Gehring, Ronette and De Backer, Patrick and Antonissen, Gunther},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keyword      = {NONSTEROIDAL ANTIINFLAMMATORY DRUGS,PARROTS AMAZONA-VENTRALIS,DOGS,PHARMACODYNAMICS,BIRDS,PATTERN,HUMANS,PLASMA,COXIBS,FOOD},
  language     = {eng},
  pages        = {12},
  title        = {Comparative population pharmacokinetics and absolute oral bioavailability of COX-2 selective inhibitors celecoxib, mavacoxib and meloxicam in cockatiels (Nymphicus hollandicus)},
  url          = {http://dx.doi.org/10.1038/s41598-017-12159-z},
  volume       = {7},
  year         = {2017},
}

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