Advanced search
2 files | 1.51 MB Add to list

Autonomic symptoms in patients with moderate and severe chronic obstructive pulmonary disease

Jibril Mohammed (UGent) , Eric Derom (UGent) , Inge De Wandele (UGent) , Lies Rombaut (UGent) and Patrick Calders (UGent)
(2018) ACTA CLINICA BELGICA. 73(3). p.182-190
Author
Organization
Abstract
Objectives: A synoptic description of the autonomic symptoms profile (ASP) of patients with COPD is not available. Therefore, we aimed to provide an overview of autonomic symptoms and its associates in COPD. Methods: We evaluated 89 subjects with COPD (657.3years; 66 males; GOLD II-IV) with an equal number of age- and sex-matched control subjects by means of the composite autonomic symptom score (COMPASS 31) questionnaire, which assesses autonomic symptoms across six domains (orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, urinary and pupillomotor). Lung function, medication use and health status variables (quality of life: physical/mental component summary [PCS/MCS], fatigue, anxiety, depression and dyspnea levels) were also assessed. Results: Compared to controls, all subjects with COPD reported significantly higher orthostatic intolerance, secretomotor and total autonomic symptom scores (p<.05). Additionally, subjects with moderate COPD also reported significantly higher scores for vasomotor, gastrointestinal, urinary and pupillomotor symptoms compared to controls (p<.05). Nevertheless, these symptoms were comparable between the moderate and severe COPD subgroups (p>.05). The COPD subjects had poorer health status compared to controls as exhibited by significantly higher scores for depression, anxiety, fatigue and dyspnea, and lower scores values for PCS and MCS scores (p<.05). These health status variables were mildly associated with autonomic symptoms (0.214r0.421; p<.05), but not with demographic and lung function (p>.05). The MCS was the only significant predictor of total autonomic symptoms score in COPD (p=0.001; =-0.430). Conclusion: Autonomic symptoms are present in all domains of the COMPASS-31 in COPD, irrespective of disease severity and demographic variables. Autonomic symptoms in COPD were mainly influenced by poor mental health.
Keywords
Autonomic nervous system, chronic obstructive, pulmonary disease, symptoms, health status, COPD, DEPRESSION, THERAPY, ANXIETY, SCALE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.14 MB
  • (...).pdf
    • supplementary material
    • |
    • UGent only
    • |
    • PDF
    • |
    • 372.86 KB

Citation

Please use this url to cite or link to this publication:

MLA
Mohammed, Jibril et al. “Autonomic Symptoms in Patients with Moderate and Severe Chronic Obstructive Pulmonary Disease.” Ed. Mirko Petrovic. ACTA CLINICA BELGICA 73.3 (2018): 182–190. Print.
APA
Mohammed, Jibril, Derom, E., De Wandele, I., Rombaut, L., & Calders, P. (2018). Autonomic symptoms in patients with moderate and severe chronic obstructive pulmonary disease. (M. Petrovic, Ed.)ACTA CLINICA BELGICA, 73(3), 182–190.
Chicago author-date
Mohammed, Jibril, Eric Derom, Inge De Wandele, Lies Rombaut, and Patrick Calders. 2018. “Autonomic Symptoms in Patients with Moderate and Severe Chronic Obstructive Pulmonary Disease.” Ed. Mirko Petrovic. Acta Clinica Belgica 73 (3): 182–190.
Chicago author-date (all authors)
Mohammed, Jibril, Eric Derom, Inge De Wandele, Lies Rombaut, and Patrick Calders. 2018. “Autonomic Symptoms in Patients with Moderate and Severe Chronic Obstructive Pulmonary Disease.” Ed. Mirko Petrovic. Acta Clinica Belgica 73 (3): 182–190.
Vancouver
1.
Mohammed J, Derom E, De Wandele I, Rombaut L, Calders P. Autonomic symptoms in patients with moderate and severe chronic obstructive pulmonary disease. Petrovic M, editor. ACTA CLINICA BELGICA. 2018;73(3):182–90.
IEEE
[1]
J. Mohammed, E. Derom, I. De Wandele, L. Rombaut, and P. Calders, “Autonomic symptoms in patients with moderate and severe chronic obstructive pulmonary disease,” ACTA CLINICA BELGICA, vol. 73, no. 3, pp. 182–190, 2018.
@article{8532103,
  abstract     = {Objectives: A synoptic description of the autonomic symptoms profile (ASP) of patients with COPD is not available. Therefore, we aimed to provide an overview of autonomic symptoms and its associates in COPD.
Methods: We evaluated 89 subjects with COPD (657.3years; 66 males; GOLD II-IV) with an equal number of age- and sex-matched control subjects by means of the composite autonomic symptom score (COMPASS 31) questionnaire, which assesses autonomic symptoms across six domains (orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, urinary and pupillomotor). Lung function, medication use and health status variables (quality of life: physical/mental component summary [PCS/MCS], fatigue, anxiety, depression and dyspnea levels) were also assessed.
Results: Compared to controls, all subjects with COPD reported significantly higher orthostatic intolerance, secretomotor and total autonomic symptom scores (p<.05). Additionally, subjects with moderate COPD also reported significantly higher scores for vasomotor, gastrointestinal, urinary and pupillomotor symptoms compared to controls (p<.05). Nevertheless, these symptoms were comparable between the moderate and severe COPD subgroups (p>.05). The COPD subjects had poorer health status compared to controls as exhibited by significantly higher scores for depression, anxiety, fatigue and dyspnea, and lower scores values for PCS and MCS scores (p<.05). These health status variables were mildly associated with autonomic symptoms (0.214r0.421; p<.05), but not with demographic and lung function (p>.05). The MCS was the only significant predictor of total autonomic symptoms score in COPD (p=0.001; =-0.430).
Conclusion: Autonomic symptoms are present in all domains of the COMPASS-31 in COPD, irrespective of disease severity and demographic variables. Autonomic symptoms in COPD were mainly influenced by poor mental health.},
  author       = {Mohammed, Jibril and Derom, Eric and De Wandele, Inge and Rombaut, Lies and Calders, Patrick},
  editor       = {Petrovic, Mirko},
  issn         = {1784-3286},
  journal      = {ACTA CLINICA BELGICA},
  keywords     = {Autonomic nervous system,chronic obstructive,pulmonary disease,symptoms,health status,COPD,DEPRESSION,THERAPY,ANXIETY,SCALE},
  language     = {eng},
  number       = {3},
  pages        = {182--190},
  title        = {Autonomic symptoms in patients with moderate and severe chronic obstructive pulmonary disease},
  url          = {http://dx.doi.org/10.1080/17843286.2017.1379255},
  volume       = {73},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: