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Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo

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Abstract
The expression of certain bacterial genes is regulated in a cell-density dependent way, a phenomenon called quorum sensing. Both Gram-negative and Gram-positive bacteria use this type of communication, though the signal molecules (auto-inducers) used by them differ between both groups: Gram-negative bacteria use predominantly N-acyl homoserine lacton (AHL) molecules (autoinducer-1, AI-1) while Gram-positive bacteria use mainly peptides (autoinducer peptides, AIP or quorum sensing peptides). These quorum sensing molecules are not only involved in the inter-microbial communication, but can also possibly cross-talk directly or indirectly with their host. This review summarizes the currently applied analytical approaches for quorum sensing identification and quantification with additionally summarizing the experimentally found in vivo concentrations of these molecules in humans.
Keywords
quorum sensing peptides, analytical methods, reporter bacteria, biosensors, chromatography, microbiome, N-ACYLHOMOSERINE LACTONES, CHROMATOGRAPHY-MASS-SPECTROMETRY, GRAM-NEGATIVE BACTERIA, N-3-OXODODECANOYL HOMOSERINE LACTONE, THIN-LAYER-CHROMATOGRAPHY, SEX-PHEROMONE INHIBITOR, GUT-BRAIN AXIS, PSEUDOMONAS-AERUGINOSA AUTOINDUCER, TETRACYCLINE RESISTANCE PLASMID, NEUROENDOCRINE STRESS HORMONES

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MLA
Verbeke, Frederick et al. “Peptides as Quorum Sensing Molecules : Measurement Techniques and Obtained Levels in Vitro and in Vivo.” FRONTIERS IN NEUROSCIENCE 11 (2017): n. pag. Print.
APA
Verbeke, Frederick, De Craemer, S., Debunne, N., Janssens, Y., Wynendaele, E., Van de Wiele, C., & De Spiegeleer, B. (2017). Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo. FRONTIERS IN NEUROSCIENCE, 11.
Chicago author-date
Verbeke, Frederick, Severine De Craemer, Nathan Debunne, Yorick Janssens, Evelien Wynendaele, Christophe Van de Wiele, and Bart De Spiegeleer. 2017. “Peptides as Quorum Sensing Molecules : Measurement Techniques and Obtained Levels in Vitro and in Vivo.” Frontiers in Neuroscience 11.
Chicago author-date (all authors)
Verbeke, Frederick, Severine De Craemer, Nathan Debunne, Yorick Janssens, Evelien Wynendaele, Christophe Van de Wiele, and Bart De Spiegeleer. 2017. “Peptides as Quorum Sensing Molecules : Measurement Techniques and Obtained Levels in Vitro and in Vivo.” Frontiers in Neuroscience 11.
Vancouver
1.
Verbeke F, De Craemer S, Debunne N, Janssens Y, Wynendaele E, Van de Wiele C, et al. Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo. FRONTIERS IN NEUROSCIENCE. 2017;11.
IEEE
[1]
F. Verbeke et al., “Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo,” FRONTIERS IN NEUROSCIENCE, vol. 11, 2017.
@article{8531996,
  abstract     = {The expression of certain bacterial genes is regulated in a cell-density dependent way, a phenomenon called quorum sensing. Both Gram-negative and Gram-positive bacteria use this type of communication, though the signal molecules (auto-inducers) used by them differ between both groups: Gram-negative bacteria use predominantly N-acyl homoserine lacton (AHL) molecules (autoinducer-1, AI-1) while Gram-positive bacteria use mainly peptides (autoinducer peptides, AIP or quorum sensing peptides). These quorum sensing molecules are not only involved in the inter-microbial communication, but can also possibly cross-talk directly or indirectly with their host. This review summarizes the currently applied analytical approaches for quorum sensing identification and quantification with additionally summarizing the experimentally found in vivo concentrations of these molecules in humans.},
  articleno    = {183},
  author       = {Verbeke, Frederick and De Craemer, Severine and Debunne, Nathan and Janssens, Yorick and Wynendaele, Evelien and Van de Wiele, Christophe and De Spiegeleer, Bart},
  issn         = {1662-453X},
  journal      = {FRONTIERS IN NEUROSCIENCE},
  keywords     = {quorum sensing peptides,analytical methods,reporter bacteria,biosensors,chromatography,microbiome,N-ACYLHOMOSERINE LACTONES,CHROMATOGRAPHY-MASS-SPECTROMETRY,GRAM-NEGATIVE BACTERIA,N-3-OXODODECANOYL HOMOSERINE LACTONE,THIN-LAYER-CHROMATOGRAPHY,SEX-PHEROMONE INHIBITOR,GUT-BRAIN AXIS,PSEUDOMONAS-AERUGINOSA AUTOINDUCER,TETRACYCLINE RESISTANCE PLASMID,NEUROENDOCRINE STRESS HORMONES},
  language     = {eng},
  pages        = {18},
  title        = {Peptides as quorum sensing molecules : measurement techniques and obtained levels in vitro and in vivo},
  url          = {http://dx.doi.org/10.3389/fnins.2017.00183},
  volume       = {11},
  year         = {2017},
}

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