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Endomyocardial and pericardial aspergillosis in critically ill patients

(2017) MYCOSES. 60(9). p.576-580
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Abstract
Invasive aspergillosis(IA) is a potentially lethal complication of Aspergillus infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of IA, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial/pericardial aspergillosis were evaluated. Risk factors, clinical and laboratory characteristics, treatment, histopathological characteristics and mortality were recorded. Signs and symptoms of cardiac dysfunction were not observed in any of the patients. Therapy was administered to six of them shortly after the first positive culture. The observed histopathological lesions included haemorrhagic lesions, small vessels with central thrombosis and surrounding consolidated tissue with necrosis. Voriconazole, caspofungin, lipid amphotericin B and itraconazole were the used antifungals. The mortality rate was high (87.5%). Endomyocardial and pericardial aspergillosis are devastating complications of invasive aspergillosis. Clinical suspicion is low making the diagnosis difficult, therefore histopathological examination of tissues are required. The mortality is high.
Keywords
aspergillosis, critically ill, endomyocardium, pericardium, INVASIVE PULMONARY ASPERGILLOSIS, FUNGAL-INFECTIONS, RISK-FACTORS, EMBOLIZATION, ENDOCARDITIS, CONSENSUS, FEATURES, AUTOPSY, TRENDS, HOST

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Chicago
Dimopoulos, George, Frantzeska Frantzeskaki, Marinos Kosmopoulos, Fabio Sylvio Taccone, Anne-Marie Van den Abeele, Pierre Bulpa, Frederic Forêt, et al. 2017. “Endomyocardial and Pericardial Aspergillosis in Critically Ill Patients.” Mycoses 60 (9): 576–580.
APA
Dimopoulos, G., Frantzeskaki, F., Kosmopoulos, M., Taccone, F. S., Van den Abeele, A.-M., Bulpa, P., Forêt, F., et al. (2017). Endomyocardial and pericardial aspergillosis in critically ill patients. MYCOSES, 60(9), 576–580.
Vancouver
1.
Dimopoulos G, Frantzeskaki F, Kosmopoulos M, Taccone FS, Van den Abeele A-M, Bulpa P, et al. Endomyocardial and pericardial aspergillosis in critically ill patients. MYCOSES. 2017;60(9):576–80.
MLA
Dimopoulos, George, Frantzeska Frantzeskaki, Marinos Kosmopoulos, et al. “Endomyocardial and Pericardial Aspergillosis in Critically Ill Patients.” MYCOSES 60.9 (2017): 576–580. Print.
@article{8531975,
  abstract     = {Invasive aspergillosis(IA) is a potentially lethal complication of Aspergillus infection affecting mainly immunocompromised hosts; however, during the last two decades its incidence was increasingly observed in critically ill immunocompetent patients. The objective of this study is to describe the clinical characteristics of histologically proven endomyocardial and pericardial invasion, in the context of IA, in critically ill patients. Eight critically ill patients with histopathological confirmation of endomyocardial/pericardial aspergillosis were evaluated. Risk factors, clinical and laboratory characteristics, treatment, histopathological characteristics and mortality were recorded. Signs and symptoms of cardiac dysfunction were not observed in any of the patients. Therapy was administered to six of them shortly after the first positive culture. The observed histopathological lesions included haemorrhagic lesions, small vessels with central thrombosis and surrounding consolidated tissue with necrosis. Voriconazole, caspofungin, lipid amphotericin B and itraconazole were the used antifungals. The mortality rate was high (87.5\%). Endomyocardial and pericardial aspergillosis are devastating complications of invasive aspergillosis. Clinical suspicion is low making the diagnosis difficult, therefore histopathological examination of tissues are required. The mortality is high.},
  author       = {Dimopoulos, George and Frantzeskaki, Frantzeska and Kosmopoulos, Marinos and Taccone, Fabio Sylvio and Van den Abeele, Anne-Marie and Bulpa, Pierre and For{\^e}t, Frederic and Vogelaers, Dirk and Blot, Stijn and AspICU investigators, on behalf of and Brusselaers, Nele and Vandewoude, Koenraad},
  issn         = {0933-7407},
  journal      = {MYCOSES},
  language     = {eng},
  number       = {9},
  pages        = {576--580},
  title        = {Endomyocardial and pericardial aspergillosis in critically ill patients},
  url          = {http://dx.doi.org/10.1111/myc.12630},
  volume       = {60},
  year         = {2017},
}

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