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Acylcarnitines profile best predicts survival in horses with atypical myopathy

François Boemer, Johann Detilleux, Christophe Cello, Hélène Amory, Christel Marcillaud-Pitel, Eric Richard, Gaby van Galen, Gunther van Loon UGent, Laurence Lefère UGent and Dominique-Marie Votion (2017) PLOS ONE. 12(8).
abstract
Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
JAMAICAN VOMITING SICKNESS, ACYL-COA DEHYDROGENASE, EUROPEAN OUTBREAKS, CLINICAL-FEATURES, HYPOGLYCIN-A, ACID, METABOLITE, IDENTIFICATION, INACTIVATION, MECHANISM
journal title
PLOS ONE
PLoS One
volume
12
issue
8
article number
e0182761
pages
16 pages
Web of Science type
Article
Web of Science id
000408438600013
ISSN
1932-6203
DOI
10.1371/journal.pone.0182761
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors are co-first authors
copyright statement
I have retained and own the full copyright for this publication
id
8531350
handle
http://hdl.handle.net/1854/LU-8531350
date created
2017-09-15 19:45:33
date last changed
2017-10-05 09:37:18
@article{8531350,
  abstract     = {Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.},
  articleno    = {e0182761},
  author       = {Boemer, Fran\c{c}ois and Detilleux, Johann and Cello, Christophe and Amory, H{\'e}l{\`e}ne and Marcillaud-Pitel, Christel and Richard, Eric and van Galen, Gaby and van Loon, Gunther and Lef{\`e}re, Laurence and Votion, Dominique-Marie},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {JAMAICAN VOMITING SICKNESS,ACYL-COA DEHYDROGENASE,EUROPEAN OUTBREAKS,CLINICAL-FEATURES,HYPOGLYCIN-A,ACID,METABOLITE,IDENTIFICATION,INACTIVATION,MECHANISM},
  language     = {eng},
  number       = {8},
  pages        = {16},
  title        = {Acylcarnitines profile best predicts survival in horses with atypical myopathy},
  url          = {http://dx.doi.org/10.1371/journal.pone.0182761},
  volume       = {12},
  year         = {2017},
}

Chicago
Boemer, François, Johann Detilleux, Christophe Cello, Hélène Amory, Christel Marcillaud-Pitel, Eric Richard, Gaby van Galen, Gunther van Loon, Laurence Lefère, and Dominique-Marie Votion. 2017. “Acylcarnitines Profile Best Predicts Survival in Horses with Atypical Myopathy.” Plos One 12 (8).
APA
Boemer, François, Detilleux, J., Cello, C., Amory, H., Marcillaud-Pitel, C., Richard, E., van Galen, G., et al. (2017). Acylcarnitines profile best predicts survival in horses with atypical myopathy. PLOS ONE, 12(8).
Vancouver
1.
Boemer F, Detilleux J, Cello C, Amory H, Marcillaud-Pitel C, Richard E, et al. Acylcarnitines profile best predicts survival in horses with atypical myopathy. PLOS ONE. 2017;12(8).
MLA
Boemer, François, Johann Detilleux, Christophe Cello, et al. “Acylcarnitines Profile Best Predicts Survival in Horses with Atypical Myopathy.” PLOS ONE 12.8 (2017): n. pag. Print.