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Acylcarnitines profile best predicts survival in horses with atypical myopathy

(2017) PLOS ONE. 12(8).
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Abstract
Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.
Keywords
JAMAICAN VOMITING SICKNESS, ACYL-COA DEHYDROGENASE, EUROPEAN OUTBREAKS, CLINICAL-FEATURES, HYPOGLYCIN-A, ACID, METABOLITE, IDENTIFICATION, INACTIVATION, MECHANISM

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Chicago
Boemer, François, Johann Detilleux, Christophe Cello, Hélène Amory, Christel Marcillaud-Pitel, Eric Richard, Gaby van Galen, Gunther van Loon, Laurence Lefère, and Dominique-Marie Votion. 2017. “Acylcarnitines Profile Best Predicts Survival in Horses with Atypical Myopathy.” Plos One 12 (8).
APA
Boemer, François, Detilleux, J., Cello, C., Amory, H., Marcillaud-Pitel, C., Richard, E., van Galen, G., et al. (2017). Acylcarnitines profile best predicts survival in horses with atypical myopathy. PLOS ONE, 12(8).
Vancouver
1.
Boemer F, Detilleux J, Cello C, Amory H, Marcillaud-Pitel C, Richard E, et al. Acylcarnitines profile best predicts survival in horses with atypical myopathy. PLOS ONE. 2017;12(8).
MLA
Boemer, François, Johann Detilleux, Christophe Cello, et al. “Acylcarnitines Profile Best Predicts Survival in Horses with Atypical Myopathy.” PLOS ONE 12.8 (2017): n. pag. Print.
@article{8531350,
  abstract     = {Equine atypical myopathy (AM) is caused by hypoglycin A intoxication and is characterized by a high fatality rate. Predictive estimation of survival in AM horses is necessary to prevent unnecessary suffering of animals that are unlikely to survive and to focus supportive therapy on horses with a possible favourable prognosis of survival. We hypothesized that outcome may be predicted early in the course of disease based on the assumption that the acylcarnitine profile reflects the derangement of muscle energetics. We developed a statistical model to prognosticate the risk of death of diseased animals and found that estimation of outcome may be drawn from three acylcarnitines (C2, C10:2 and C18 -carnitines) with a high sensitivity and specificity. The calculation of the prognosis of survival makes it possible to distinguish the horses that will survive from those that will die despite severe signs of acute rhabdomyolysis in both groups.},
  articleno    = {e0182761},
  author       = {Boemer, Fran\c{c}ois and Detilleux, Johann and Cello, Christophe and Amory, H{\'e}l{\`e}ne and Marcillaud-Pitel, Christel and Richard, Eric and van Galen, Gaby and van Loon, Gunther and Lef{\`e}re, Laurence and Votion, Dominique-Marie},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keyword      = {JAMAICAN VOMITING SICKNESS,ACYL-COA DEHYDROGENASE,EUROPEAN OUTBREAKS,CLINICAL-FEATURES,HYPOGLYCIN-A,ACID,METABOLITE,IDENTIFICATION,INACTIVATION,MECHANISM},
  language     = {eng},
  number       = {8},
  pages        = {16},
  title        = {Acylcarnitines profile best predicts survival in horses with atypical myopathy},
  url          = {http://dx.doi.org/10.1371/journal.pone.0182761},
  volume       = {12},
  year         = {2017},
}

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