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The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis

Magdalena Woloszynska, Olimpia Gagliardi, Filip Vandenbussche UGent, Steven De Groeve UGent, Luis Alonso Baez, Pia Neyt UGent, Sabine Le Gall UGent, Jorge Fung, Paloma Mas, Dominique Van Der Straeten UGent, et al. (2018) JOURNAL OF CELL SCIENCE. 131(2).
abstract
The Elongator complex (hereafter Elongator) promotes RNA polymerase II-mediated transcript elongation through epigenetic activities such as histone acetylation. Elongator regulates growth, development, immune response and sensitivity to drought and abscisic acid. We demonstrate that elo mutants exhibit defective hypocotyl elongation but have a normal apical hook in darkness and are hyposensitive to light during photomorphogenesis. These elo phenotypes are supported by transcriptome changes, including downregulation of circadian clock components, positive regulators of skoto-or photomorphogenesis, hormonal pathways and cell wall biogenesis-related factors. The downregulated genes LHY, HFR1 and HYH are selectively targeted by Elongator for histone H3K14 acetylation in darkness. The role of Elongator in early seedling development in darkness and light is supported by hypocotyl phenotypes of mutants defective in components of the gene network regulated by Elongator, and by double mutants between elo and mutants in light or darkness signaling components. A model is proposed in which Elongator represses the plant immune response and promotes hypocotyl elongation and photomorphogenesis via transcriptional control of positive photomorphogenesis regulators and a growth-regulatory network that converges on genes involved in cell wall biogenesis and hormone signaling. This article has an associated First Person interview with the first author of the paper.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Arabidopsis, Darkness, Histone acetyl transferase complex, Hypocotyl elongation, Light, Transcript elongation, ARABIDOPSIS CIRCADIAN CLOCK, INTERACTING FACTOR PIF7, BOTRYTIS-CINEREA, CONSTITUTIVE PHOTOMORPHOGENIC1, SEEDLING PHOTOMORPHOGENESIS, TRANSCRIPTION FACTORS, PLANT DEVELOPMENT, IMMUNE-RESPONSES, MUTANTS IDENTIFY, CELL ELONGATION
journal title
JOURNAL OF CELL SCIENCE
J. Cell Sci.
editor
Jenny Russinova
volume
131
issue
2
issue title
Plant cell biology
article number
jcs203927
pages
12 pages
Web of Science type
Article
ISSN
0021-9533
1477-9137
DOI
10.1242/jcs.203927
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8531129
handle
http://hdl.handle.net/1854/LU-8531129
date created
2017-09-14 10:02:45
date last changed
2018-06-21 08:48:15
@article{8531129,
  abstract     = {The Elongator complex (hereafter Elongator) promotes RNA polymerase II-mediated transcript elongation through epigenetic activities such as histone acetylation. Elongator regulates growth, development, immune response and sensitivity to drought and abscisic acid. We demonstrate that elo mutants exhibit defective hypocotyl elongation but have a normal apical hook in darkness and are hyposensitive to light during photomorphogenesis. These elo phenotypes are supported by transcriptome changes, including downregulation of circadian clock components, positive regulators of skoto-or photomorphogenesis, hormonal pathways and cell wall biogenesis-related factors. The downregulated genes LHY, HFR1 and HYH are selectively targeted by Elongator for histone H3K14 acetylation in darkness. The role of Elongator in early seedling development in darkness and light is supported by hypocotyl phenotypes of mutants defective in components of the gene network regulated by Elongator, and by double mutants between elo and mutants in light or darkness signaling components. A model is proposed in which Elongator represses the plant immune response and promotes hypocotyl elongation and photomorphogenesis via transcriptional control of positive photomorphogenesis regulators and a growth-regulatory network that converges on genes involved in cell wall biogenesis and hormone signaling. 
This article has an associated First Person interview with the first author of the paper.},
  articleno    = {jcs203927},
  author       = {Woloszynska, Magdalena and Gagliardi, Olimpia and Vandenbussche, Filip and De Groeve, Steven and Baez, Luis Alonso and Neyt, Pia and Le Gall, Sabine and Fung, Jorge and Mas, Paloma and Van Der Straeten, Dominique and Van Lijsebettens, Maria},
  editor       = {Russinova, Jenny},
  issn         = {0021-9533},
  journal      = {JOURNAL OF CELL SCIENCE},
  keyword      = {Arabidopsis,Darkness,Histone acetyl transferase complex,Hypocotyl elongation,Light,Transcript elongation,ARABIDOPSIS CIRCADIAN CLOCK,INTERACTING FACTOR PIF7,BOTRYTIS-CINEREA,CONSTITUTIVE PHOTOMORPHOGENIC1,SEEDLING PHOTOMORPHOGENESIS,TRANSCRIPTION FACTORS,PLANT DEVELOPMENT,IMMUNE-RESPONSES,MUTANTS IDENTIFY,CELL ELONGATION},
  language     = {eng},
  number       = {2},
  pages        = {12},
  title        = {The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis},
  url          = {http://dx.doi.org/10.1242/jcs.203927},
  volume       = {131},
  year         = {2018},
}

Chicago
Woloszynska, Magdalena, Olimpia Gagliardi, Filip Vandenbussche, Steven De Groeve, Luis Alonso Baez, Pia Neyt, Sabine Le Gall, et al. 2018. “The Elongator Complex Regulates Hypocotyl Growth in Darkness and During Photomorphogenesis.” Ed. Jenny Russinova. Journal of Cell Science 131 (2).
APA
Woloszynska, M., Gagliardi, O., Vandenbussche, F., De Groeve, S., Baez, L. A., Neyt, P., Le Gall, S., et al. (2018). The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis. (J. Russinova, Ed.)JOURNAL OF CELL SCIENCE, 131(2).
Vancouver
1.
Woloszynska M, Gagliardi O, Vandenbussche F, De Groeve S, Baez LA, Neyt P, et al. The Elongator complex regulates hypocotyl growth in darkness and during photomorphogenesis. Russinova J, editor. JOURNAL OF CELL SCIENCE. 2018;131(2).
MLA
Woloszynska, Magdalena, Olimpia Gagliardi, Filip Vandenbussche, et al. “The Elongator Complex Regulates Hypocotyl Growth in Darkness and During Photomorphogenesis.” Ed. Jenny Russinova. JOURNAL OF CELL SCIENCE 131.2 (2018): n. pag. Print.