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Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs

Bram Flahou, Mirko Rossi, Jaco Bakker, Jan AM Langermans, Edwin Heuvelman, Jay V Solnick, Miriam E Martin, Jani O’Rourke, Le Duc Ngoan, Nguyen Xuan Hoa, et al. (2018) ISME JOURNAL. 12(1). p.77-86
abstract
Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MACACA-FASCICULARIS, STAPHYLOCOCCUS-AUREUS, GASTRIC HELICOBACTER, COMPARATIVE GENOMICS, PYLORI INFECTION, ANCIENT DNA, WILD, PREVALENCE, HEILMANNII, PORCINE
journal title
ISME JOURNAL
ISME J.
volume
12
issue
1
pages
77 - 86
Web of Science type
Article
Web of Science id
000418293300006
ISSN
1751-7362
1751-7370
DOI
10.1038/ismej.2017.145
language
English
UGent publication?
yes
classification
A1
additional info
the first two and the last two authors contributed equally to this work
copyright statement
I have transferred the copyright for this publication to the publisher
id
8530804
handle
http://hdl.handle.net/1854/LU-8530804
date created
2017-09-11 08:36:27
date last changed
2018-03-08 09:30:20
@article{8530804,
  abstract     = {Helicobacter suis is the second most prevalent Helicobacter species in the stomach of humans suffering from gastric disease. This bacterium mainly inhabits the stomach of domesticated pigs, in which it causes gastric disease, but it appears to be absent in wild boars. Interestingly, it also colonizes the stomach of asymptomatic rhesus and cynomolgus monkeys. The origin of modern human-, pig- or non-human primate-associated H. suis strains in these respective host populations was hitherto unknown. Here we show that H. suis in pigs possibly originates from non-human primates. Our data suggest that a host jump from macaques to pigs happened between 100 000 and 15 000 years ago and that pig domestication has had a significant impact on the spread of H. suis in the pig population, from where this pathogen occasionally infects humans. Thus, in contrast to our expectations, H. suis appears to have evolved in its main host in a completely different way than its close relative Helicobacter pylori in humans.},
  author       = {Flahou, Bram and Rossi, Mirko and Bakker, Jaco and Langermans, Jan AM and Heuvelman, Edwin and Solnick, Jay V and Martin, Miriam E and O{\textquoteright}Rourke, Jani and Ngoan, Le Duc and Hoa, Nguyen Xuan and Nakamura, Masahiko and {\O}verby, Anders and Matsui, Hidenori and Ota, Hiroyoshi and Matsumoto, Takehisa and Foss, Dennis L and Kopta, Laurice A and Omotosho, Oladipo and Franciosini, Maria Pia and Casagrande Proietti, Patrizia and Guo, Aizhen and Liu, Han and Borilova, Gabriela and Bracarense, Ana Paula and Lind{\'e}n, Sara K and De Bruyckere, Sofie and Zhang, Guangzhi and De Witte, Chlo{\"e} and Smet, Annemieke and Pasmans, Frank and Ducatelle, Richard and Corander, Jukka and Haesebrouck, Freddy},
  issn         = {1751-7362},
  journal      = {ISME JOURNAL},
  keyword      = {MACACA-FASCICULARIS,STAPHYLOCOCCUS-AUREUS,GASTRIC HELICOBACTER,COMPARATIVE GENOMICS,PYLORI INFECTION,ANCIENT DNA,WILD,PREVALENCE,HEILMANNII,PORCINE},
  language     = {eng},
  number       = {1},
  pages        = {77--86},
  title        = {Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs},
  url          = {http://dx.doi.org/10.1038/ismej.2017.145},
  volume       = {12},
  year         = {2018},
}

Chicago
Flahou, Bram, Mirko Rossi, Jaco Bakker, Jan AM Langermans, Edwin Heuvelman, Jay V Solnick, Miriam E Martin, et al. 2018. “Evidence for a Primate Origin of Zoonotic Helicobacter Suis Colonizing Domesticated Pigs.” Isme Journal 12 (1): 77–86.
APA
Flahou, B., Rossi, M., Bakker, J., Langermans, J. A., Heuvelman, E., Solnick, J. V., Martin, M. E., et al. (2018). Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs. ISME JOURNAL, 12(1), 77–86.
Vancouver
1.
Flahou B, Rossi M, Bakker J, Langermans JA, Heuvelman E, Solnick JV, et al. Evidence for a primate origin of zoonotic Helicobacter suis colonizing domesticated pigs. ISME JOURNAL. 2018;12(1):77–86.
MLA
Flahou, Bram, Mirko Rossi, Jaco Bakker, et al. “Evidence for a Primate Origin of Zoonotic Helicobacter Suis Colonizing Domesticated Pigs.” ISME JOURNAL 12.1 (2018): 77–86. Print.