Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans
(2017)
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES.
72(10).
p.1311-1318
- Author
- Huaihan Cai (UGent) , Madina Rasulova (UGent) , Lieselot Vandemeulebroucke, Lea Marie Meagher, Caroline Vlaeminck (UGent) , Ineke Dhondt (UGent) and Bart Braeckman (UGent)
- Organization
- Abstract
- In Caenorhabditis elegans, a broad range of dietary restriction regimens extend life span to different degrees by separate or partially overlapping molecular pathways. One of these regimens, axenic dietary restriction, doubles the worm's life span but currently, almost nothing is known about the underlying molecular mechanism. Previous studies suggest that mitochondrial stress responses such as the mitochondrial unfolded protein response (UPRmt) or mitohormesis may play a vital role in axenic dietary restriction-induced longevity. Here, we provide solid evidence that axenic dietary restriction treatment specifically induces an UPRmt response in C elegans but this induction is not required for axenic dietary restriction-mediated longevity. We also show that reactive oxygen species-mediated mitohormesis is not involved in this phenotype. Hence, changes in mitochondrial physiology and induction of a mitochondrial stress response are not necessarily causal to large increases in life span.
- Keywords
- Axenic culture, UPRmt, Longevity, C-ELEGANS, LONGEVITY, STRESS, UPR, EFFICIENCY, GROWTH
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8530773
- MLA
- Cai, Huaihan, et al. “Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis Elegans.” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 72, no. 10, 2017, pp. 1311–18, doi:10.1093/gerona/glx013.
- APA
- Cai, H., Rasulova, M., Vandemeulebroucke, L., Meagher, L. M., Vlaeminck, C., Dhondt, I., & Braeckman, B. (2017). Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 72(10), 1311–1318. https://doi.org/10.1093/gerona/glx013
- Chicago author-date
- Cai, Huaihan, Madina Rasulova, Lieselot Vandemeulebroucke, Lea Marie Meagher, Caroline Vlaeminck, Ineke Dhondt, and Bart Braeckman. 2017. “Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis Elegans.” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 72 (10): 1311–18. https://doi.org/10.1093/gerona/glx013.
- Chicago author-date (all authors)
- Cai, Huaihan, Madina Rasulova, Lieselot Vandemeulebroucke, Lea Marie Meagher, Caroline Vlaeminck, Ineke Dhondt, and Bart Braeckman. 2017. “Life-Span Extension by Axenic Dietary Restriction Is Independent of the Mitochondrial Unfolded Protein Response and Mitohormesis in Caenorhabditis Elegans.” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 72 (10): 1311–1318. doi:10.1093/gerona/glx013.
- Vancouver
- 1.Cai H, Rasulova M, Vandemeulebroucke L, Meagher LM, Vlaeminck C, Dhondt I, et al. Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2017;72(10):1311–8.
- IEEE
- [1]H. Cai et al., “Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans,” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 72, no. 10, pp. 1311–1318, 2017.
@article{8530773,
abstract = {{In Caenorhabditis elegans, a broad range of dietary restriction regimens extend life span to different degrees by separate or partially overlapping molecular pathways. One of these regimens, axenic dietary restriction, doubles the worm's life span but currently, almost nothing is known about the underlying molecular mechanism. Previous studies suggest that mitochondrial stress responses such as the mitochondrial unfolded protein response (UPRmt) or mitohormesis may play a vital role in axenic dietary restriction-induced longevity. Here, we provide solid evidence that axenic dietary restriction treatment specifically induces an UPRmt response in C elegans but this induction is not required for axenic dietary restriction-mediated longevity. We also show that reactive oxygen species-mediated mitohormesis is not involved in this phenotype. Hence, changes in mitochondrial physiology and induction of a mitochondrial stress response are not necessarily causal to large increases in life span.}},
author = {{Cai, Huaihan and Rasulova, Madina and Vandemeulebroucke, Lieselot and Meagher, Lea Marie and Vlaeminck, Caroline and Dhondt, Ineke and Braeckman, Bart}},
issn = {{1079-5006}},
journal = {{JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES}},
keywords = {{Axenic culture,UPRmt,Longevity,C-ELEGANS,LONGEVITY,STRESS,UPR,EFFICIENCY,GROWTH}},
language = {{eng}},
number = {{10}},
pages = {{1311--1318}},
title = {{Life-span extension by axenic dietary restriction is independent of the mitochondrial unfolded protein response and mitohormesis in Caenorhabditis elegans}},
url = {{http://doi.org/10.1093/gerona/glx013}},
volume = {{72}},
year = {{2017}},
}
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