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A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment

(2015) IEEE SENSORS JOURNAL. 15(1). p.417-424
Author
Organization
Abstract
This paper represents the extended version of the conference paper "Developing highly-integrated subcutaneous biochips for remote monitoring of human metabolism" presented at the IEEE Sensors Conference 2012, and presents data on assembly, packaging and short term in vitro and in vivo biocompatibility evaluation of a fully implantable biosensor array. The device was realized integrating three building blocks: 1) a multielectrode platform; 2) an inductive coil; and 3) an integrated circuit. The entire system measures 2.2 mm x 2.2 mm x 15 mm. Corrosion of electronic components and leaking of potentially hazardous substances in the body is prevented with a conformal coating of Parylene C, while an outer package of medical grade silicone was employed to create a soft shell suitable for implantation. Biocompatibility experiments did not show in vitro cytotoxicity in the considered period of 7 days, while comparison between 7 and 30 days in vivo implantations showed significant reduction of the inflammatory response in time, suggesting normal host recovery.
Keywords
MULTILAYER SPIRAL INDUCTORS, WALLED CARBON NANOTUBES, ACUTE-INFLAMMATION, LOCAL INFECTION, RABBITS, Biosensors, implantable biomedical devices, electronics packaging

Citation

Please use this url to cite or link to this publication:

MLA
Cavallini, Andrea et al. “A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment.” IEEE SENSORS JOURNAL 15.1 (2015): 417–424. Print.
APA
Cavallini, A., Jost, T. R., Ghoreishizadeh, S. S., Olivo, J., Op de Beeck, M., Gorissen, B., Grassi, F., et al. (2015). A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment. IEEE SENSORS JOURNAL, 15(1), 417–424.
Chicago author-date
Cavallini, Andrea, Tanja Rezzonico Jost, Seyedeh Sara Ghoreishizadeh, Jacopo Olivo, Maaike Op de Beeck, Benjamin Gorissen, Fabio Grassi, Giovanni De Micheli, and Sandro Carrara. 2015. “A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment.” Ieee Sensors Journal 15 (1): 417–424.
Chicago author-date (all authors)
Cavallini, Andrea, Tanja Rezzonico Jost, Seyedeh Sara Ghoreishizadeh, Jacopo Olivo, Maaike Op de Beeck, Benjamin Gorissen, Fabio Grassi, Giovanni De Micheli, and Sandro Carrara. 2015. “A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment.” Ieee Sensors Journal 15 (1): 417–424.
Vancouver
1.
Cavallini A, Jost TR, Ghoreishizadeh SS, Olivo J, Op de Beeck M, Gorissen B, et al. A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment. IEEE SENSORS JOURNAL. Piscataway: Ieee-inst Electrical Electronics Engineers Inc; 2015;15(1):417–24.
IEEE
[1]
A. Cavallini et al., “A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment,” IEEE SENSORS JOURNAL, vol. 15, no. 1, pp. 417–424, 2015.
@article{8530655,
  abstract     = {{This paper represents the extended version of the conference paper "Developing highly-integrated subcutaneous biochips for remote monitoring of human metabolism" presented at the IEEE Sensors Conference 2012, and presents data on assembly, packaging and short term in vitro and in vivo biocompatibility evaluation of a fully implantable biosensor array. The device was realized integrating three building blocks: 1) a multielectrode platform; 2) an inductive coil; and 3) an integrated circuit. The entire system measures 2.2 mm x 2.2 mm x 15 mm. Corrosion of electronic components and leaking of potentially hazardous substances in the body is prevented with a conformal coating of Parylene C, while an outer package of medical grade silicone was employed to create a soft shell suitable for implantation. Biocompatibility experiments did not show in vitro cytotoxicity in the considered period of 7 days, while comparison between 7 and 30 days in vivo implantations showed significant reduction of the inflammatory response in time, suggesting normal host recovery.}},
  author       = {{Cavallini, Andrea and Jost, Tanja Rezzonico and Ghoreishizadeh, Seyedeh Sara and Olivo, Jacopo and Op de Beeck, Maaike and Gorissen, Benjamin and Grassi, Fabio and De Micheli, Giovanni and Carrara, Sandro}},
  issn         = {{1530-437X}},
  journal      = {{IEEE SENSORS JOURNAL}},
  keywords     = {{MULTILAYER SPIRAL INDUCTORS,WALLED CARBON NANOTUBES,ACUTE-INFLAMMATION,LOCAL INFECTION,RABBITS,Biosensors,implantable biomedical devices,electronics packaging}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{417--424}},
  publisher    = {{Ieee-inst Electrical Electronics Engineers Inc}},
  title        = {{A Subcutaneous Biochip for Remote Monitoring of Human Metabolism : Packaging and Biocompatibility Assessment}},
  url          = {{http://dx.doi.org/10.1109/JSEN.2014.2339638}},
  volume       = {{15}},
  year         = {{2015}},
}

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