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Fully Integrated Biochip Platforms for Advanced Healthcare

(2012) SENSORS. 12(8). p.11013-11060
Author
Organization
Abstract
Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.
Keywords
LANGMUIR-BLODGETT-FILMS, WALLED CARBON NANOTUBES, DIRECT, ELECTRON-TRANSFER, IMPLANTABLE MEDICAL DEVICES, HYDROGEN-PEROXIDE, DETECTION, SCREEN-PRINTED ELECTRODES, CHEMICAL-VAPOR-DEPOSITION, GLUCOSE, BIOSENSOR, ELECTROCHEMICAL BIOSENSORS, CONDUCTING POLYMERS, biochip, CMOS design, enzymes, biotechnology, nanotechnology, potentiostats, biocompatible membranes, security, privacy, remote, powering

Citation

Please use this url to cite or link to this publication:

MLA
Carrara, Sandro, et al. “Fully Integrated Biochip Platforms for Advanced Healthcare.” SENSORS, vol. 12, no. 8, Mdpi Ag, 2012, pp. 11013–60, doi:10.3390/s120811013.
APA
Carrara, S., Ghoreishizadeh, S., Olivo, J., Taurino, I., Baj-Rossi, C., Cavallini, A., … De Micheli, G. (2012). Fully Integrated Biochip Platforms for Advanced Healthcare. SENSORS, 12(8), 11013–11060. https://doi.org/10.3390/s120811013
Chicago author-date
Carrara, Sandro, Sara Ghoreishizadeh, Jacopo Olivo, Irene Taurino, Camilla Baj-Rossi, Andrea Cavallini, Maaike Op de Beeck, et al. 2012. “Fully Integrated Biochip Platforms for Advanced Healthcare.” SENSORS 12 (8): 11013–60. https://doi.org/10.3390/s120811013.
Chicago author-date (all authors)
Carrara, Sandro, Sara Ghoreishizadeh, Jacopo Olivo, Irene Taurino, Camilla Baj-Rossi, Andrea Cavallini, Maaike Op de Beeck, Catherine Dehollain, Wayne Burleson, Francis Gabriel Moussy, Anthony Guiseppi-Elie, and Giovanni De Micheli. 2012. “Fully Integrated Biochip Platforms for Advanced Healthcare.” SENSORS 12 (8): 11013–11060. doi:10.3390/s120811013.
Vancouver
1.
Carrara S, Ghoreishizadeh S, Olivo J, Taurino I, Baj-Rossi C, Cavallini A, et al. Fully Integrated Biochip Platforms for Advanced Healthcare. SENSORS. 2012;12(8):11013–60.
IEEE
[1]
S. Carrara et al., “Fully Integrated Biochip Platforms for Advanced Healthcare,” SENSORS, vol. 12, no. 8, pp. 11013–11060, 2012.
@article{8530651,
  abstract     = {{Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications.}},
  author       = {{Carrara, Sandro and Ghoreishizadeh, Sara and Olivo, Jacopo and Taurino, Irene and Baj-Rossi, Camilla and Cavallini, Andrea and Op de Beeck, Maaike and Dehollain, Catherine and Burleson, Wayne and Moussy, Francis Gabriel and Guiseppi-Elie, Anthony and De Micheli, Giovanni}},
  issn         = {{1424-8220}},
  journal      = {{SENSORS}},
  keywords     = {{LANGMUIR-BLODGETT-FILMS,WALLED CARBON NANOTUBES,DIRECT,ELECTRON-TRANSFER,IMPLANTABLE MEDICAL DEVICES,HYDROGEN-PEROXIDE,DETECTION,SCREEN-PRINTED ELECTRODES,CHEMICAL-VAPOR-DEPOSITION,GLUCOSE,BIOSENSOR,ELECTROCHEMICAL BIOSENSORS,CONDUCTING POLYMERS,biochip,CMOS design,enzymes,biotechnology,nanotechnology,potentiostats,biocompatible membranes,security,privacy,remote,powering}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{11013--11060}},
  publisher    = {{Mdpi Ag}},
  title        = {{Fully Integrated Biochip Platforms for Advanced Healthcare}},
  url          = {{http://dx.doi.org/10.3390/s120811013}},
  volume       = {{12}},
  year         = {{2012}},
}

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