Advanced search
1 file | 423.94 KB Add to list

The EuroMyositis registry : an international collaborative tool to facilitate myositis research

Author
Organization
Abstract
Aims: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. Methods: Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. Results: Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001). Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001). ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases ('V' sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%. Conclusion: This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.
Keywords
IDIOPATHIC INFLAMMATORY MYOPATHIES, CLASSIFICATION, DERMATOMYOSITIS, AUTOANTIBODIES, ADULT, POLYMYOSITIS, CRITERIA, DISEASE, ANTIBODIES, DIAGNOSIS

Downloads

  • 2017AnnRheumDis.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 423.94 KB

Citation

Please use this url to cite or link to this publication:

MLA
Lilleker, James B, Jiri Vencovsky, Guochun Wang, et al. “The EuroMyositis Registry : an International Collaborative Tool to Facilitate Myositis Research.” ANNALS OF THE RHEUMATIC DISEASES 77.1 (2018): 30–39. Print.
APA
Lilleker, J. B., Vencovsky, J., Wang, G., Wedderburn, L. R., Diederichsen, L. P., Schmidt, J., Oakley, P., et al. (2018). The EuroMyositis registry : an international collaborative tool to facilitate myositis research. ANNALS OF THE RHEUMATIC DISEASES, 77(1), 30–39.
Chicago author-date
Lilleker, James B, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, et al. 2018. “The EuroMyositis Registry : an International Collaborative Tool to Facilitate Myositis Research.” Annals of the Rheumatic Diseases 77 (1): 30–39.
Chicago author-date (all authors)
Lilleker, James B, Jiri Vencovsky, Guochun Wang, Lucy R Wedderburn, Louise Pyndt Diederichsen, Jens Schmidt, Paula Oakley, Olivier Benveniste, Maria Giovanna Danieli, Katalin Danko, Nguyen Thi Phuong Thuy, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan De Bleecker, Britta Maurer, Liza J McCann, Nicolo Pipitone, Neil McHugh, Zoe E Betteridge, Paul New, Robert G Cooper, William E Ollier, Janine A Lamb, Niels Steen Krogh, Ingrid E Lundberg, and Hector Chinoy. 2018. “The EuroMyositis Registry : an International Collaborative Tool to Facilitate Myositis Research.” Annals of the Rheumatic Diseases 77 (1): 30–39.
Vancouver
1.
Lilleker JB, Vencovsky J, Wang G, Wedderburn LR, Diederichsen LP, Schmidt J, et al. The EuroMyositis registry : an international collaborative tool to facilitate myositis research. ANNALS OF THE RHEUMATIC DISEASES. 2018;77(1):30–9.
IEEE
[1]
J. B. Lilleker et al., “The EuroMyositis registry : an international collaborative tool to facilitate myositis research,” ANNALS OF THE RHEUMATIC DISEASES, vol. 77, no. 1, pp. 30–39, 2018.
@article{8529960,
  abstract     = {Aims: The EuroMyositis Registry facilitates collaboration across the idiopathic inflammatory myopathy (IIM) research community. This inaugural report examines pooled Registry data. 
Methods: Cross-sectional analysis of IIM cases from 11 countries was performed. Associations between clinical subtypes, extramuscular involvement, environmental exposures and medications were investigated. 
Results: Of 3067 IIM cases, 69% were female. The most common IIM subtype was dermatomyositis (DM) (31%). Smoking was more frequent in connective tissue disease overlap cases (45%, OR 1.44, 95% CI 1.09 to 1.90, p=0.012). Smoking was associated with interstitial lung disease (ILD) (OR 1.32, 95% CI 1.06 to 1.65, p=0.013), dysphagia (OR 1.43, 95% CI 1.16 to 1.77, p=0.001), malignancy ever (OR 1.78, 95% CI 1.36 to 2.33, p<0.001) and cardiac involvement (OR 2.40, 95% CI 1.60 to 3.60, p<0.001). Dysphagia occurred in 39% and cardiac involvement in 9%; either occurrence was associated with higher Health Assessment Questionnaire (HAQ) scores (adjusted OR 1.79, 95% CI 1.43 to 2.23, p<0.001). HAQ scores were also higher in inclusion body myositis cases (adjusted OR 3.85, 95% CI 2.52 to 5.90, p<0.001). Malignancy (ever) occurred in 13%, most commonly in DM (20%, OR 2.06, 95% CI 1.65 to 2.57, p<0.001). ILD occurred in 30%, most frequently in antisynthetase syndrome (71%, OR 10.7, 95% CI 8.6 to 13.4, p<0.001). Rash characteristics differed between adult-onset and juvenile-onset DM cases ('V' sign: 56% DM vs 16% juvenile-DM, OR 0.16, 95% CI 0.07 to 0.36, p<0.001). Glucocorticoids were used in 98% of cases, methotrexate in 71% and azathioprine in 51%. 
Conclusion: This large multicentre cohort demonstrates the importance of extramuscular involvement in patients with IIM, its association with smoking and its influence on disease severity. Our findings emphasise that IIM is a multisystem inflammatory disease and will help inform prognosis and clinical management of patients.},
  author       = {Lilleker, James B and Vencovsky, Jiri and Wang, Guochun and Wedderburn, Lucy R and Diederichsen, Louise Pyndt and Schmidt, Jens and Oakley, Paula and Benveniste, Olivier and Danieli, Maria Giovanna and Danko, Katalin and Thuy, Nguyen Thi Phuong and Vazquez-Del Mercado, Monica and Andersson, Helena and De Paepe, Boel and De Bleecker, Jan and Maurer, Britta and McCann, Liza J and Pipitone, Nicolo and McHugh, Neil and Betteridge, Zoe E and New, Paul and Cooper, Robert G and Ollier, William E and Lamb, Janine A and Steen Krogh, Niels and Lundberg, Ingrid E and Chinoy, Hector},
  issn         = {0003-4967},
  journal      = {ANNALS OF THE RHEUMATIC DISEASES},
  keywords     = {IDIOPATHIC INFLAMMATORY MYOPATHIES,CLASSIFICATION,DERMATOMYOSITIS,AUTOANTIBODIES,ADULT,POLYMYOSITIS,CRITERIA,DISEASE,ANTIBODIES,DIAGNOSIS},
  language     = {eng},
  number       = {1},
  pages        = {30--39},
  title        = {The EuroMyositis registry : an international collaborative tool to facilitate myositis research},
  url          = {http://dx.doi.org/10.1136/annrheumdis-2017-211868},
  volume       = {77},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: