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Serological diagnosis of Taenia solium in pigs : no measurable circulating antigens and antibody response following exposure to Taenia saginata oncospheres

Pierre Dorny UGent, V Dermauw, A Van Hul, C Trevisan and Sarah Gabriël UGent (2017) VETERINARY PARASITOLOGY. 245. p.39-41
abstract
Taenia solium taeniasis/cysticercosis is a zoonosis included in the WHO's list of neglected tropical diseases. Accurate diagnostic tools for humans and pigs are needed to monitor intervention outcomes. Currently used diagnostic tools for porcine cysticercosis all have drawbacks. Serological tests are mainly confronted with problems of specificity. More specifically, circulating antigen detecting tests cross-react with Taenia hydatigena and the possibility of transient antigens as a result of aborted infections is suspected. Furthermore, the hypothesis has been raised that hatched ingested eggs of other Taenia species may lead to a transient antibody response or to the presence of circulating antigen detectable by serological tests used for porcine cysticercosis. Here we describe the results of a study that consisted of oral administration of Taenia saginata eggs to five piglets followed by serological testing during five weeks and necropsy aiming at studying possible cross reactions in serological tests used for porcine cysticercosis. The infectivity of the eggs was verified by in vitro hatching and by experimental infection of a calf. One piglet developed acute respiratory disease and died on day 6 post infection. The remaining four piglets did not show any clinical signs until euthanasia. None of the serum samples from four piglets collected between days 0 and 35 post infection gave a positive reaction in the B158/B60 Ag-ELISA and in a commercial Western blot for antibody detection. In conclusion, this study showed that experimental exposure of four pigs to T. saginata eggs did not result in positive serologies for T. solium. These results may help interpreting serological results in monitoring of T. solium control programmes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Taenia solium, Taenia saginata, Pig, Cysticercosis, Immunodiagnosis, Specificity, PORCINE CYSTICERCOSIS, SENTINEL PIGS, PREVALENCE, CATTLE
journal title
VETERINARY PARASITOLOGY
Vet. Parasitol.
volume
245
pages
39 - 41
Web of Science type
Article
Web of Science id
000413614300006
ISSN
0304-4017
DOI
10.1016/j.vetpar.2017.08.008
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
8529852
handle
http://hdl.handle.net/1854/LU-8529852
date created
2017-08-30 07:35:25
date last changed
2018-03-08 10:15:39
@article{8529852,
  abstract     = {Taenia solium taeniasis/cysticercosis is a zoonosis included in the WHO's list of neglected tropical diseases. Accurate diagnostic tools for humans and pigs are needed to monitor intervention outcomes. Currently used diagnostic tools for porcine cysticercosis all have drawbacks. Serological tests are mainly confronted with problems of specificity. More specifically, circulating antigen detecting tests cross-react with Taenia hydatigena and the possibility of transient antigens as a result of aborted infections is suspected. Furthermore, the hypothesis has been raised that hatched ingested eggs of other Taenia species may lead to a transient antibody response or to the presence of circulating antigen detectable by serological tests used for porcine cysticercosis. Here we describe the results of a study that consisted of oral administration of Taenia saginata eggs to five piglets followed by serological testing during five weeks and necropsy aiming at studying possible cross reactions in serological tests used for porcine cysticercosis. The infectivity of the eggs was verified by in vitro hatching and by experimental infection of a calf. One piglet developed acute respiratory disease and died on day 6 post infection. The remaining four piglets did not show any clinical signs until euthanasia. None of the serum samples from four piglets collected between days 0 and 35 post infection gave a positive reaction in the B158/B60 Ag-ELISA and in a commercial Western blot for antibody detection. In conclusion, this study showed that experimental exposure of four pigs to T. saginata eggs did not result in positive serologies for T. solium. These results may help interpreting serological results in monitoring of T. solium control programmes.},
  author       = {Dorny, Pierre and Dermauw, V and Van Hul, A and Trevisan, C and Gabri{\"e}l, Sarah},
  issn         = {0304-4017},
  journal      = {VETERINARY PARASITOLOGY},
  keyword      = {Taenia solium,Taenia saginata,Pig,Cysticercosis,Immunodiagnosis,Specificity,PORCINE CYSTICERCOSIS,SENTINEL PIGS,PREVALENCE,CATTLE},
  language     = {eng},
  pages        = {39--41},
  title        = {Serological diagnosis of Taenia solium in pigs : no measurable circulating antigens and antibody response following exposure to Taenia saginata oncospheres},
  url          = {http://dx.doi.org/10.1016/j.vetpar.2017.08.008},
  volume       = {245},
  year         = {2017},
}

Chicago
Dorny, Pierre, V Dermauw, A Van Hul, C Trevisan, and Sarah Gabriël. 2017. “Serological Diagnosis of Taenia Solium in Pigs : No Measurable Circulating Antigens and Antibody Response Following Exposure to Taenia Saginata Oncospheres.” Veterinary Parasitology 245: 39–41.
APA
Dorny, P., Dermauw, V., Van Hul, A., Trevisan, C., & Gabriël, S. (2017). Serological diagnosis of Taenia solium in pigs : no measurable circulating antigens and antibody response following exposure to Taenia saginata oncospheres. VETERINARY PARASITOLOGY, 245, 39–41.
Vancouver
1.
Dorny P, Dermauw V, Van Hul A, Trevisan C, Gabriël S. Serological diagnosis of Taenia solium in pigs : no measurable circulating antigens and antibody response following exposure to Taenia saginata oncospheres. VETERINARY PARASITOLOGY. 2017;245:39–41.
MLA
Dorny, Pierre, V Dermauw, A Van Hul, et al. “Serological Diagnosis of Taenia Solium in Pigs : No Measurable Circulating Antigens and Antibody Response Following Exposure to Taenia Saginata Oncospheres.” VETERINARY PARASITOLOGY 245 (2017): 39–41. Print.